High rate of biological loss in assisted reproduction: it is in the seed, not in the soil

Patrizio, Pasquale; Bianchi, Veronica; Lalioti,; Gerasimova, Tsilya; Sakkas, Denny

doi:10.1016/s1472-6483(10)60769-9

Cited by 56 publications

(28 citation statements)

References 11 publications

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“…In a previous report, we reported that 77.1 % (13/57) of embryos displayed a chromosomal abnormality for the advanced maternal age group (above 35 years old) [17]. The chromosomal abnormality rate for women 43 years or beyond in our own analysis was found to be 80.…”

Section: Discussionsupporting

confidence: 48%

Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs

Çetinkaya

Siano

Benadiva

et al. 2013

J Assist Reprod Genet

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Purpose The aim of this study was to analyze the outcomes of IVF/ICSI cycles in women aged 43 and beyond. Methods Retrospective analysis of clinical pregnancy and live birth rates in168 fresh, non donor, ART cycles performed in two Connecticut university IVF programs. Results In women of 43 and 44 years the overall clinical pregnancy and live birth rates were 8.3 % and 5.3 % per initiated cycle, respectively. There were no clinical pregnancies in women ≥45 years old. First cycle characteristics were not different from repeated cycles in terms of duration of ovulation induction, number of collected oocytes and transferred embryos (p>0.05). Conclusions Pregnancies can still be achieved with IVF/ICSI up to the age of 44. Since most pregnancies occurred within the first 3 cycles, another attempt may be a reasonable option before resorting to oocyte donation for patients who failed two previous cycles. Women 45 years and beyond do not benefit from ART procedures using their own oocytes.

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Section: Discussionsupporting

confidence: 48%

Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs

Çetinkaya

Siano

Benadiva

et al. 2013

J Assist Reprod Genet

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“…Is it possible, that as seen through the course of reproductive life, that some follicles are doomed to atresia, and this cannot be corrected with ideal culture systems under any circumstances? This is highly reminiscent of the clinical situation, where a fraction of oocytes retrieved after gonadotropic stimulation seems always incapable of supporting blastocyst development and the generation of healthy babies (Patrizio et al 2007 ). Accordingly, in vitro culture results in a high level of follicle attrition by atresia.…”

Section: Recreating the Crime Scene: Models Used Dissect The Control mentioning

confidence: 99%

The Control of Oocyte Survival by Intrinsic and Extrinsic Factors

Kuruş

Karakaya

Karalok

et al. 2013

Advances in Experimental Medicine and Biology

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Mechanisms that control the survival of oocytes and, by extension, the duration of ovarian function have been identified. However, it is still not clear whether oocyte "quality" is related to survival, nor is the role of the granulosa cells of follicles in follicle survival entirely understood. Here, we consider oocyte-intrinsic and oocyte-extrinsic mechanisms of oocyte loss and argue that developing a better understanding of such physiological events is needed to protect fertility, fecundity, and ovarian function in women.The duration that ovaries function is, as is intuitive, controlled by the number of remaining oocytes within follicles. Once the number of follicles drops beneath a threshold number, ovarian function ceases. Thus, understanding mechanisms that control oocyte survival is paramount as we consider strategies to protect or prolong ovarian function in women. It is often assumed that physiological oocyte survival is entirely controlled by "oocyte- intrinsic" factors, such as poor genetic quality or accumulated damage to the oocyte itself. Oocytes that have poor genetic quality due to development or accumulated damage would then die sooner than those of higher "quality." Indeed, new data suggest that oocyte-intrinsic genetic quality as determined by the ability to repair double-stranded DNA breaks is a significant contributor to oocyte survival and the duration of ovarian function. However, the nature of the follicle, where the oocyte and surrounding granulosa cells exist in intimate contact and rely upon each other for survival signals and metabolic function, makes it unlikely that oocyte-intrinsic factors entirely control oocyte survival. We and others are assessing the role of adjacent somatic (granulosa) cells in follicle survival, determining the relative importance of "oocyte-extrinsic" factors.

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“…Despite significant advancements in the field, the process of human reproduction remains inefficient with many unanswered biological questions [2,3]. Previous work analyzed the number of embryos transferred compared to the number of live births and showed that the majority of embryos produced during IVF cycles (about 85%) and chosen for transfer fail to result in a live born infant [4].…”

Section: Introductionmentioning

confidence: 99%

Embryo wastage rates remain high in assisted reproductive technology (ART): a look at the trends from 2004–2013 in the USA

Ghazal¹,

Patrizio²

2016

J Assist Reprod Genet

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This work examined the trend in Bembryo wastager ates after ART in USA and its relationship to the number of embryos transferred, live born infants delivered across patient age, and the yearly percentage of embryos wasted. The data were obtained from the US-clinics SART databank for the years 2004-2013. A total of 1,808,082 non-donor embryos were transferred in 748,394 fresh cycles resulting in 358,214 liveborn. During the years of analysis, the mean number of embryos transferred has progressively decreased leading to an overall significant decrease in Embryo Wastage rates (83.2 to 76.5%, p < 0.001) while the percentage of transfers leading to a live born increased (24.8 to 27.8%, p = 0.002). Embryo Wastage negatively correlated with percentage of transfers resulting in live birth (p = 0.001), and the average number of embryos transferred positively correlated with the percentage of embryos wasted (p < 0.001). The overwhelming majority of embryos transferred still do not result into a live birth confirming that only few embryos per ART cycle are competent. The overall BEmbryo Wastage^rates have consistently decreased from a high of 90% in 1995 to a rate of 76.5% in 2013. Transferring fewer embryos particularly at the blastocyst-stage and improved methods of embryo selection may further decrease BEmbryo Wastage^rates.

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High rate of biological loss in assisted reproduction: it is in the seed, not in the soil

Cited by 56 publications

References 11 publications

Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs

Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs

The Control of Oocyte Survival by Intrinsic and Extrinsic Factors

Embryo wastage rates remain high in assisted reproductive technology (ART): a look at the trends from 2004–2013 in the USA

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