High rate of GB virus type C/HGV transmission from mother to infant: possible implications for the prevalence of infection in blood donors

Lefrère, Jean‐Jacques; Сендер, Анна Николаевна; Mercier, Bernard; Mariotti, Martine; Pernot, F.; Soulié, Jean-Christophe; Malvoisin, A.; Berry, Michael J.; Gabai, A.; Lattes, F.; Galiay, J.‐C.; Pawlak, Catherine; Lachaux, V. De; Chauveau, V.; Hreiche, G.; Larsen, Marcelo; Férec, Claude; Parnet-Mathieu, F; Roudot‐Thoraval, Françoise; Brossard, Y.

doi:10.1046/j.1537-2995.2000.40050602.x

Cited by 33 publications

(26 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rate of GBV-C viremia in individuals with HCV infection is 15% to 20%, and up to 40% among HIV-positive people who acquired HIV through sexual transmission [29••,30,36-38], supporting both parenteral and sexual modes of transmission of GBV-C. Several studies have found evidence that sexual transmission of GBV-C occurs [29••,42-47]. GBV-C may also be transmitted vertically, and 89% of infants of HIV-negative and HCV-negative women with GBV-C infection had GBV-C RNA detected between 3 and 9 months of life in one study [48].…”

Section: Gb Virus C Prevalence and Diseasementioning

confidence: 96%

Interactions between GB virus type C and HIV

George¹,

Wünschmann²,

McCoy

et al. 2002

Curr Infect Dis Rep

View full text Add to dashboard Cite

GB virus C (GBV-C, also known as hepatitis G virus) commonly causes human infection. Genetically, it is closely related to hepatitis C virus, but GBV-C appears to grow primarily in lymphocytes, not hepatocytes. Although it causes persistent infection in about 25% to 50% of infected individuals, numerous studies have failed to connect GBV-C with any disease process. GBV-C is transmitted sexually, parenterally, and vertically, and due to these shared modes of transmission, coinfection is common among HIV-infected individuals. Of 10 studies done of HIV-GBV-C coinfection, eight found a beneficial effect of GBV-C viremia on HIV-related mortality or response to therapy. The mechanism by which GBV-C may improve survival of HIV-positive people is not known; however, in vitro studies suggest that GBV-C inhibits HIV replication, and preliminary data also point toward alterations in cytokine and/or chemokine expression by GBV-C-infected cells.

show abstract

Section: Gb Virus C Prevalence and Diseasementioning

confidence: 96%

Interactions between GB virus type C and HIV

George¹,

Wünschmann²,

McCoy

et al. 2002

Curr Infect Dis Rep

View full text Add to dashboard Cite

show abstract

“…Parenteral exposure has been documented to be the main mode of transmission for GBV-C/HGV. Sexual and vertical transmissions appear to play an important role as well [Hadziyannis and Hess, 1998;Karayiannis and Thomas, 1998;Scallan et al, 1998;Bourlet et al, 1999;Lefrere et al, 1999Lefrere et al, , 2000Stark et al, 1999]. Whether other transmission routes might be operating for GBV-C/HGV remains unknown.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of GB virus C/hepatitis G virus genotype 3 among autochthonous Venezuelan populations

Loureiro

Alonso

Pacheco

et al. 2002

Journal of Medical Virology

View full text Add to dashboard Cite

GB virus C or hepatitis G virus (GBV-C/HGV) is highly prevalent among population groups at risk of parenterally transmitted viral agents, but it has also a worldwide distribution in other non-risk population groups. GBV-C/HGV RNA and antibodies against its envelope protein (anti-E2 Abs) were found in 3/86 (3%) and 7/89 (8%) of biomedical science personnel (BSP), in 31/453 (7%) and 37/200 (19%) of blood donors (BD), and in 6/64 (9%) and 26/59 (44%) of hemodialysis patients (HD) from Caracas, Venezuela. A significant gradient of GBV-C/HGV exposure (anti-E2 Abs and/or GBV-C/HGV RNA) was found between BSP (lowest prevalence), BD, and HD (P < 0.001). GBV-C/HGV RNA and anti-E2 Abs were also found in 2/69 (2.9%) and 2/44 (4.5%) of individuals from a rural community, in 9/162 (5.5%) and 2/40 (5%) of West Amerindians, and in 14/56 (25%) and 4/53 (7.5%) of South Amerindians. Socioeconomic and cultural factors may have contributed to the relatively high risk of exposure to GBV-C/HGV in BD and Amerindians. Whereas GBV-C/HGV genotypes 1 (n = 1), 2 (n = 6), and 3 (n = 22) were present in Venezuela, only the Asiatic genotype 3 was found infecting Amerindians and rural populations (n = 16). Genotype assignment based on the 5' noncoding region of the GBV- C/HGV genome was corroborated in some isolates by genetic analysis of the E2 region. This report confirms the circulation of the Asiatic genotype of GBV-C/HGV among Amerindians, suggesting an old origin of GBV-C/HGV. This might be associated with the apparently low pathogenesis of this virus.

show abstract

“…The prevalence of GBV-C infection in the general population is higher than that of other bloodborne viruses, such as human immunodeficiency virus (HIV) and hepatitis C virus in western industrialized countries and varies globally, as does GBV-C genotype. Among antenatal populations, the prevalence of GBV-C RNA varies from 1%-2% in East Asia [1,2] to 5%-7% in Europe, Australia, and Southeast Asia [3][4][5][6] and 10%-13% in Africa [7,8]. GBV-C infection is also more prevalent in HIV-infected persons and others with risk factors for bloodborne infections [9] and can be transmitted parenterally, sexually, and vertically [10].…”

mentioning

confidence: 99%

“…GBV-C infection is also more prevalent in HIV-infected persons and others with risk factors for bloodborne infections [9] and can be transmitted parenterally, sexually, and vertically [10]. Mother-to-child transmission (MTCT) of GBV-C has been hypothesized as one possible mechanism for the relatively high prevalence of GBV-C infection in the general population [4,11,12].…”

mentioning

confidence: 99%

Mother‐to‐Child Transmission of GB Virus C in a Cohort of Women Coinfected with GB Virus C and HIV in Bangkok, Thailand

et al. 2009

View full text Add to dashboard Cite

show abstract

High rate of GB virus type C/HGV transmission from mother to infant: possible implications for the prevalence of infection in blood donors

Abstract: The frequency of mother-to-infant GBV-C/HGV transmission is elevated and could explain the high prevalence of GBV-C/HGV markers (viral RNA and E2 antibody) in adults at low risk for blood-borne or sexually transmitted viruses, such as blood donors.

Cited by 33 publications

References 32 publications

Interactions between GB virus type C and HIV

Interactions between GB virus type C and HIV

High prevalence of GB virus C/hepatitis G virus genotype 3 among autochthonous Venezuelan populations

Mother‐to‐Child Transmission of GB Virus C in a Cohort of Women Coinfected with GB Virus C and HIV in Bangkok, Thailand

Contact Info

Product

Resources

About