High Rate of Infectivity and Liver Disease in Blood Donors with Antibodies to Hepatitis C Virus

Esteban, Juan Ignacio; López-Talavera, Juan Carlos; Genescà, J.; Madoz, P; Viladomiu, L; Muñíz, Eduardo; Martín‐Vega, Carmen; Rosell, Manuel; Allende, Helena; Vidal, Xavier; González, Antonio; Hernández, José Manuel González; Esteban, Rafael; Guàrdia, J

doi:10.7326/0003-4819-115-6-443

Cited by 268 publications

(100 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are few other case-control studies in blood donors [7,8], none from the UK, and this is the first study to use the more specific RIBA-2 test [6]. All three studies found associations with injecting drugs, tattoos and blood transfusion.…”

Section: Discussionmentioning

confidence: 83%

“…All three studies found associations with injecting drugs, tattoos and blood transfusion. It is difficult to make comparisons on other associations between the three studies due to different donor recruitment policies, the choice of inappropriate controls [7], the effects of the less specific RIBA-1 test and lower participation rates [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…The introduction of routine screening of all blood donations in the UK, together with confirmation of the screening test by a more specific second-generation RIBA-2 test [6] has identified a group of apparently healthy people with hepatitis C infection. Previous studies on blood donors have used first-generation Recombinant Immunoblot Assay (RIBA) tests [7,8]. To evaluate risk factors for HCV in blood donors we undertook a case-control study of blood donors in the Trent region.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

et al. 1994

View full text Add to dashboard Cite

SUMMARYThe introduction of screening for hepatitis C virus (HCV) by the National Blood Transfusion Service identified donors who had acquired HCV infection. We undertook a case-control study amongst blood donors in the Trent Region to determine risks for HCV infection. A total of 74 blood donors confirmed positive for hepatitis C infection and 150 age, sex and donor venue matched controls were included in the study. Fifty-three percent of hepatitis C infected blood donors reported previous use of injected drugs compared to no controls; relative risk (RR) not estimatable (lower limit 95% CI = 20). Other risk factors were a history of: receipt of a blood transfusion or blood products RR = 3-6 (95% CI 15-8-3), having been a 'health care worker' RR = 2-8 (95% CI 1t 1-76), tattooing RR = 3 3 (95% CI 1-2-8-7), and an association with having been born abroad RR = 3 2 (95% CI 1-1-95). No risk was shown for a history of multiple sexual partners, ear piercing or acupuncture. Injecting drug use explains more than 50 % of hepatitis C infections in blood donors, a group who are less likely to have injected drugs than the general population.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

et al. 1994

View full text Add to dashboard Cite

show abstract

“…The fourth case had detectable viremia at months 6, 12 and 24 after therapy, in spite of having normal ALT values in monthly assessments. Thus, "residual" or low-level replication of HCV, might not preclude long-term remission of chronic hepatitis C. Further studies are needed to clarify whether healthy carriers exist or whether a smoldering hepatic disease persists in x, iremic patients with normal ALT.values, as suggested by the presence of periportal inflammation 1 year after finishing therapy in one case in our study with persistent serum HCV RNA and also by one study of blood donors with confirmed anti-HCV antibodies and persistently normal ALT levels (32). However, another study indicates that persistent viremia may be found in individuals with normal histology and normal aminotransferase values (33).…”

Section: Discussionmentioning

confidence: 65%

Prediction of sustained remission of chronic hepatitis C after a 12-month course of alfa interferon

Camps

Garcı́a-Granero

Riezu-Boj

et al. 1994

Journal of Hepatology

View full text Add to dashboard Cite

a-Interferon therapy normalizes aminotransferase levels in approximately 50°/,, of the patients with chronic hepatitis C, but post-therapy relapses are common and predictive factors of sustained response remain largely unknown. We retrospectively assessed several parameters as predictors of sustained remission after a 12-month course of lymphoblastoid txinterferon: the Knodell histological activity index, serum levels of procollagen type III peptide, serum HCV-RNA, antia-interferon antibodies, and anti-HCV antibodies (C-100-3), all at month 12. Thirty-seven patients were studied. Fourteen patients were non-responders (38%), 15 patients experienced a sustained response (40.5%) and eight patients responded similarly but relapsed after a-interferon withdrawal (21.5°/,,). A decrease in the histological activity index above 5, normalization of procollagen type III peptide levels (<12 ng/ml) and the absence of viremia after treatment were all significantly associated with a sustained response (p=0.008, p=0.007 and p=0.037, respectively). Anti-interferon antibodies were detected in only one non-responder patient. Anti-C-100-3 antibodies became undetectable at month 12 in 5 of the 15 sustained responders. The best prediction of sustained response was obtained from the three variables independent of multivariate analysis according to the following equation: F=0.872+0.067×K (decrease of histological index) -0.052×P (procollagen type III peptide levels at month 12) -0.28×R (HCV-RNA at month 12; R=2 when present and R= 1 when absent). A score higher than 0 predicted sustained remission with a 100°/,, sensitivity and specificity in this series of patients. The results of this study may be useful in establishing the optimal duration of a-interferon therapy. © Journal of Hepatology.

show abstract

“…There is a wide geographical variation of HCV prevalence in the general population (Choo et al 1990, Contreras et al 1991, Esteban et al 1991, ElSayed et al 1996, Guadagnino et al 1997. In Brazil data on HCV prevalence are mainly available from blood banks (Vanderborght et al 1993, Silva et al 1995.…”

mentioning

confidence: 99%

Hepatitis C virus prevalence among an immigrant community to the Southern Amazon, Brazil

Souto

Fontes

Martelli

et al. 1999

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

A community-based random survey was conducted in a southern Brazilian Amazonian county aiming to investigate hepatitis C virus (HCV) infection prevalence and the association of demographic variables and lifestyle behaviours. Seven hundred eighty individuals were serologically screened with a third generation enzyme-linked immunosorbent assay to detect anti-HCV antibodies between 1994/1995. Positive samples were retested for confirmation with a line immunoassay (LIA, Inno-LIA HCV Ab III). Most of these subjects were low income and came from southern Brazilian states (65.8). Two point four percent (IC 95% 1.2%-4.6%) of the subjects had LIA-confirmed anti-HCV antibodies reactivity. The age-specific prevalence of HCV antibodies slightly increased with age, with the highest prevalence after the age of 40 years. The results of multivariate analysis indicate a strong association between HCV antibodies and previous surgery and history of intravenous drug use. There were no apparent association with gender, hepatitis B virus markers, blood transfusion, and sexual activity. Mean time living in Amazon did not differ between confirmed and negative anti-HCV individuals. The present data point out an intermediate endemicity of HCV infection among this immigrant community to the Amazon region and that few HCV infected participants presented known risk factors.

show abstract

High Rate of Infectivity and Liver Disease in Blood Donors with Antibodies to Hepatitis C Virus

Abstract: In our geographic area, almost 70% of donors who are anti-HCV positive by ELISA are confirmed to be positive by RIBA-2; most of these donors appear to be chronic carriers of HCV and have substantial liver disease.

Cited by 268 publications

References 13 publications

Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

Prediction of sustained remission of chronic hepatitis C after a 12-month course of alfa interferon

Hepatitis C virus prevalence among an immigrant community to the Southern Amazon, Brazil

Contact Info

Product

Resources

About