High rate of levofloxacin resistance in a background of clarithromycin- and metronidazole-resistant Helicobacter pylori in Vietnam

Phan, Trung Nam; Santona, Antonella; Tran, Van Huy; Tran, Thi Ngoc Anh; Lê, Văn An; Cappuccinelli, Pietro Antonio; Rubino, Salvatore; Paglietti, Bianca

doi:10.1016/j.ijantimicag.2014.10.019

Cited by 59 publications

(74 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This issue is of particular relevance with regard to clarithromycin, which can induce virtually a 70% loss of effectiveness in the standard triple therapy (proton pump inhibitor, PPI + clarithromycin + amoxicillin) in patients infected with clarithromycin resistant strains versus susceptible strains [11]. Unfortunately, recent data of H. pylori antibiotic resistance in Vietnam showed that the resistance rate to clarithromycin, the key antibiotic for first-line treatment, was very high, in order of 33-34.2% for primary and 73.7% for secondary resistance in adult patients [12,13], and notably, over 50% in children patients [14].…”

Section: H Pylori Antibiotic Resistance In Vietnammentioning

confidence: 99%

“…Moreover, resistance rate to levofloxacin, the alternative drug after first-line eradication treatment failure with the standard triple or quadruple therapy, is also remarkably high in Vietnam, ranging from 18.4% in 2008 to 35.6% for primary resistance and 63.2% for secondary resistance in 2014, showing a rapid acquisition of resistance to levofloxacin in nearly 5 years [12,13]. The resistance towards these two key antibiotics occurred in a high background level of resistance to metronidazole varying from 69.9% to 76,1% [12,13].…”

Section: H Pylori Antibiotic Resistance In Vietnammentioning

confidence: 99%

“…The resistance towards these two key antibiotics occurred in a high background level of resistance to metronidazole varying from 69.9% to 76,1% [12,13].…”

Section: H Pylori Antibiotic Resistance In Vietnammentioning

confidence: 99%

“…However, the low resistance to amoxicillin detected in Vietnam indicates that it probably occurred in exceptional cases with less than 2% of reports [12][13][14].…”

Section: H Pylori Antibiotic Resistance In Vietnammentioning

confidence: 99%

See 3 more Smart Citations

Antimicrobial resistance in Helicobacter pylori: current situation and management strategy in Vietnam

Phan

Tran

et al. 2015

J Infect Dev Ctries

Self Cite

View full text Add to dashboard Cite

Increasing antimicrobial resistance to key antibiotics in Helicobacter pylori has become a main cause of treatment failures in many countries, including Vietnam. For this reason it is advisable to perform antimicrobial sensitivity tests to provide more focused regimens for H. pylori eradication. However, this approach is generally unavailable for H. pylori in Vietnam and the selection of treatment regimens is mainly based on the trend of antibiotic use in the population, resistance development in the region, and history of H. pylori eradication of patients. The aim of this review is to examine the current situation of antimicrobial resistance in Vietnam and suggest management strategies for treatment selection.

show abstract

Section: H Pylori Antibiotic Resistance In Vietnammentioning

confidence: 99%

Section: H Pylori Antibiotic Resistance In Vietnammentioning

confidence: 99%

“…The resistance towards these two key antibiotics occurred in a high background level of resistance to metronidazole varying from 69.9% to 76,1% [12,13].…”

Section: H Pylori Antibiotic Resistance In Vietnammentioning

confidence: 99%

“…However, the low resistance to amoxicillin detected in Vietnam indicates that it probably occurred in exceptional cases with less than 2% of reports [12][13][14].…”

Section: H Pylori Antibiotic Resistance In Vietnammentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial resistance in Helicobacter pylori: current situation and management strategy in Vietnam

Phan

Tran

et al. 2015

J Infect Dev Ctries

Self Cite

View full text Add to dashboard Cite

show abstract

“…The unintentional side effect was that, in addition to curing the primary infection, antibiotic treatment was also eliminating H. pylori from the stomach in many [18] and is now a problem in many populations in both the developing world [19,20] and in several countries in southern Europe, although considerably less in countries where antibiotic use is more strictly controlled [21].…”

Section: H Pylori In Health and Diseasementioning

confidence: 99%

Helicobacter pylori: enemy, commensal or, sometimes, friend?

Whalen¹,

Massidda²

2015

J Infect Dev Ctries

View full text Add to dashboard Cite

Helicobacter pylori is a Gram-negative ε-proteobacterium that colonizes about 50% of humans. Some pertinent characteristics are that it can survive the acid of the stomach, produces urease to neutralize it and is motile due to apical flagella. Not surprisingly given its wide distribution, it has long colonized mankind and its genome encodes many features that allows this. Consequently, it frequently has a persistent lifelong association with humans and, differently from most pathogens that are transmitted horizontally, it is preferentially transmitted vertically, often from mother to child. A variety of genes and polymorphisms, both in H pylori and in humans, mediate the complex host-bacterium relationship, and can also determine if and what pathologies will be triggered by the species. H. pylori is naturally transformable, very recombinogenic and has a high mutation rate. Microbiota studies of the stomach have shown it to be an important species with a potentially regulatory role for the gastric microbial community. Likewise, epidemiological work has suggested that, while it clearly increases the risk of peptic ulcers and gastric cancer in some populations, it is also associated with lower risk of esophageal cancer and several other important pathologies. More recently, antibacterial resistant strains have been isolated, posing a problem for public health officials who called for its eradication. Hence, study of H. pylori and how it interacts with us can help revealing mutualistic or pathogenic interactions and the immune response in the digestive niche.

show abstract

Antibiotic resistance in Helicobacter pylori: From potential biomolecular mechanisms to clinical practice

Lin

Shao

Yan

et al. 2023

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is a gram-negative microaerobic bacterium that is a common pathogen widely distributed around the world, especially in developing countries. 1 According to statistics from recent years, the H. pylori infection rate in developing countries exceeds 50%. 2 In West Asia, Africa, and South America, the H. pylori infection rate has been reported to be as high as 66.6%, 70.1%, and 69.4%, respectively. 3 H. pylori infection causes persistent damage to human gastric mucosa, leading to a variety of digestive

show abstract

High rate of levofloxacin resistance in a background of clarithromycin- and metronidazole-resistant Helicobacter pylori in Vietnam

Cited by 59 publications

References 31 publications

Antimicrobial resistance in Helicobacter pylori: current situation and management strategy in Vietnam

Antimicrobial resistance in Helicobacter pylori: current situation and management strategy in Vietnam

Helicobacter pylori: enemy, commensal or, sometimes, friend?

Antibiotic resistance in Helicobacter pylori: From potential biomolecular mechanisms to clinical practice

Contact Info

Product

Resources

About