High rate of spontaneous viral clearance in a cohort of vertically infected hepatitis C virus infants: what lies behind?

Ceci, O; Margiotta, M.; Marello, Fiorino; Francavilla, Ruggiero; Lerardi, Enzo; Loizzi, P; Impedovo, Luigi; Francavilla, A.

doi:10.1016/s0168-8278(01)00205-7

Cited by 23 publications

(14 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transmission of HCV from mother to child (vertical transmission) occurs in approximately 5% of all infants born to HCV-infected women [1][2][3][4][5][6][7][8]. Although maternal HCV viraemia is associated with an increased risk of vertical transmission, transmission can occur from non-viraemic women [9].…”

Section: Introductionmentioning

confidence: 99%

Excluding hepatitis C virus (HCV) infection by serology in young infants of HCV‐infected mothers

et al. 2005

View full text Add to dashboard Cite

Serological confirmation of HCV uninfection remains necessary given the uncertainty in the specificity of virological tests. These results suggest that, in most children, HCV infection can be ruled out with serological testing at an earlier age than previously thought, and that nearly all children born to HCV-infected mothers will have lost passively acquired maternal antibodies by 1 y of age. Antibody loss was significantly later among children born to HCV viraemic mothers. The earlier loss of HCV antibodies in children born to HIV co-infected mothers may be due to HIV treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Excluding hepatitis C virus (HCV) infection by serology in young infants of HCV‐infected mothers

et al. 2005

View full text Add to dashboard Cite

show abstract

“…44,[60][61][62][63] In one study, three fourths of the infants identified with mother-to-infant hepatitis C cleared the HCV RNA by 2 years of age. 23,64 In another study, all 5 infants with mother-to-infant hepatitis C lost detectable serum HCV RNA by 6 months of age. 65 Thus, outcome of mother-to-infant transmission of HCV is usually considered in terms of evolution to chronic hepatitis C, with later spontaneous clearance of HCV infection or progressive chronic liver disease.…”

Section: Outcome Of Mother-to-infant Hepatitis C In Affected Infantsmentioning

confidence: 99%

Maternal-infant transmission of hepatitis C virus infection

2002

View full text Add to dashboard Cite

Mother-to-infant transmission of hepatitis C virus (HCV) is comparatively uncommon. The prevalence of antibody to HCV (anti-HCV) in pregnant women is 0.1% to 2.4%, although in some endemic areas it is much higher. The proportion of women with anti-HCV who have active infection with viremia is 60% to 70%. Transmission of HCV occurs only when serum HCV RNA is detectable and may be related to higher levels (above 10 6 copies per mL). M aternal and child health issues relating to hepatitis C virus (HCV) infection have recently assumed greater importance than ever before. From the pediatric perspective, the availability of effective screening methods for HCV has virtually eliminated new cases of transfusion-associated hepatitis C in children. Consequently, childhood acquisition of HCV infection through maternal-infant transmission has become the most important mode of spread. 1 Vertical, or more precisely, mother-to-infant hepatitis C will likely be the major type of childhood chronic hepatitis C within the next 6 to 8 years. It has been difficult to determine the rate of mother-to-infant transmission, partly because reports of mother-to-infant transmission of HCV have been based on small numbers of patients, with differing disease definitions, followed with different study designs and using different virological assays. These reports tended to be heterogeneous and conflicting. Moreover, factors that promote mother-to-infant transmission and the outcome of chronic HCV infection acquired by this route still require clarification. Likewise, for women of child-bearing age who acquired chronic hepatitis C in childhood or in early adulthood, there are important issues relating to pregnancy itself, such as its effect on the disease course of chronic hepatitis C. Prevalence of Hepatitis C Among Pregnant WomenNumerous studies have examined the prevalence of hepatitis C among pregnant women (Table 1). The studies vary considerably in terms of the size of the study, geographic variables, and adequacy of laboratory testing. In general, the prevalence of detectable antibody to HCV (anti-HCV) is approximately 1% overall (range, 0.1% to 2.4%), based on the studies that included at least 3,000 subjects. The mean Abbreviations: HCV, hepatitis C virus; anti-HCV, antibody to HCV; ALT, alanine aminotransferase; HIV, human immunodeficiency virus.

show abstract

“…But there are no reports of fulminant hepatitis developing among infected infants. Furthermore, such an infected infant is usually asymptomatic and is not affected in terms of growth. 4 Approximately 30% of infants who are HCV infected through mother‐to‐infant transmission become negative for HCV‐RNA in blood in the natural course of infection by the time they are 3 years old 1,10 . But it has not been clarified whether the virus is completely eliminated from the body, and the possibility that the infants will become HCV‐RNA positive again later in their life cannot be denied. 5 For infants who are still HCV‐RNA‐positive after 3 years of age, increases in AST and ALT levels are occasionally observed.…”

Section: Knowledge To Date On Hcv Transmission From Mother To Infantmentioning

confidence: 99%

“…4 Approximately 30% of infants who are HCV infected through mother‐to‐infant transmission become negative for HCV‐RNA in blood in the natural course of infection by the time they are 3 years old 1,10 . But it has not been clarified whether the virus is completely eliminated from the body, and the possibility that the infants will become HCV‐RNA positive again later in their life cannot be denied.…”

Section: Knowledge To Date On Hcv Transmission From Mother To Infantmentioning

confidence: 99%

Guidelines for care of pregnant women carrying hepatitis C virus and their infants

Shiraki

Ohto

Inaba

et al. 2008

Pediatrics International

View full text Add to dashboard Cite

Here, we present guidelines for doctors in consulting and treating hepatitis C virus (HCV)-carrying pregnant women and their infants. Because there are no specifi c guidelines, there is confusion in consulting and treating HCV-carrying gravidas and their infants, causing anxiety to these women and their families. This survey was based on a prospective study that involved screening pregnant women for anti-HCV in Japan from 2002 to 2004 and prospective observations of their children. The guidelines are based on current knowledge of mother-to-infant transmission of HCV. A revision of these guidelines is necessary when the natural history of HCV-carrying children is elucidated, or when HCV infection becomes curable.

show abstract

High rate of spontaneous viral clearance in a cohort of vertically infected hepatitis C virus infants: what lies behind?

Cited by 23 publications

References 7 publications

Excluding hepatitis C virus (HCV) infection by serology in young infants of HCV‐infected mothers

Excluding hepatitis C virus (HCV) infection by serology in young infants of HCV‐infected mothers

Maternal-infant transmission of hepatitis C virus infection

Guidelines for care of pregnant women carrying hepatitis C virus and their infants

Contact Info

Product

Resources

About