High rate of unrecognized dengue virus infection in parts of the rainforest region of Nigeria

Onoja, Anyebe Bernard; Adeniji, Johnson Adekunle; Olaleye, O.D.

doi:10.1016/j.actatropica.2016.04.007

Cited by 28 publications

(28 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the same time, major outbreaks of dengue have been reported in Dar es Salaam, including the 2014 DENV2 outbreak registering a case fatality rate of 4% ( Vairo et al, 2016 ). Dengue epidemics have also been reported from other parts of Tanzania ( Mboera et al, 2016 ), neighboring Kenya ( Brady et al, 2012 ), Mozambique ( Massangaie et al, 2016 ), as well as Angola ( Sharp et al, 2015 ), Sierra Leone ( de Araújo Lobo et al, 2016 ), Burkina Faso ( Ridde et al, 2016 ), and Nigeria ( Onoja et al, 2016 ) and several other parts of Sub-Saharan Africa ( L’Azou et al, 2015 ). Notably, in 2017, dengue outbreaks were reported from eight Sub-Saharan countries reaching an excess of 21,000 total cases.…”

Section: Evidence That Elimination Of Falciparum Malaria Coincides Wimentioning

confidence: 94%

“…In 1977, Fagbami et al found that 45% of tested adults in Nigeria were seropositive for anti-DENV-2 antibodies, as evidenced by neutralizing antibodies ( Fagbami et al, 1977 ). In several African countries DENV transmission has been recognized primarily through diagnosis of travelers or stationed military personnel or through sero-prevalence population studies ( de Araújo Lobo et al, 2016 ; Onoja et al, 2016 ). It is mainly on the basis of such evidence that dengue is considered endemic to both East and West Africa ( Brady et al, 2012 ).…”

Section: Present and Past Prevalence Of Malaria Dengue And Populatimentioning

confidence: 99%

See 1 more Smart Citation

Elimination of Falciparum Malaria and Emergence of Severe Dengue: An Independent or Interdependent Phenomenon?

2018

View full text Add to dashboard Cite

The global malaria burden, including falciparum malaria, has been reduced by 50% since 2000, though less so in Sub-Saharan Africa. Regional malaria elimination campaigns beginning in the 1940s, up-scaled in the 1950s, succeeded in the 1970s in eliminating malaria from Europe, North America, the Caribbean (except Haiti), and parts of Asia and South- and Central America. Dengue has grown dramatically throughout the pantropical regions since the 1950s, first in Southeast Asia in the form of large-scale epidemics including severe dengue, though mostly sparing Sub-Saharan Africa. Globally, the WHO estimates 50 million dengue infections every year, while others estimate almost 400 million infections, including 100 million clinical cases. Curiously, despite wide geographic overlap between malaria and dengue-endemic areas, published reports of co-infections have been scarce until recently. Superimposed acute dengue infection might be expected to result in more severe combined disease because both pathogens can induce shock and hemorrhage. However, a recent review found no reports on more severe morbidity or higher mortality associated with co-infections. Cases of severe dual infections have almost exclusively been reported from South America, and predominantly in persons infected by Plasmodium vivax. We hypothesize that malaria infection may partially protect against dengue – in particular falciparum malaria against severe dengue – and that this inter-species cross-protection may explain the near absence of severe dengue from the Sub-Saharan region and parts of South Asia until recently. We speculate that malaria infection elicits cross-reactive antibodies or other immune responses that infer cross-protection, or at least partial cross-protection, against symptomatic and severe dengue. Plasmodia have been shown to give rise to polyclonal B-cell activation and to heterophilic antibodies, while some anti-dengue IgM tests have high degree of cross-reactivity with sera from malaria patients. In the following, the historical evolution of falciparum malaria and dengue is briefly reviewed, and we explore early evidence of subclinical dengue in high-transmission malaria areas as well as conflicting reports on severity of co-morbidity. We also discuss examples of other interspecies interactions.

show abstract

Section: Evidence That Elimination Of Falciparum Malaria Coincides Wimentioning

confidence: 94%

Section: Present and Past Prevalence Of Malaria Dengue And Populatimentioning

confidence: 99%

Elimination of Falciparum Malaria and Emergence of Severe Dengue: An Independent or Interdependent Phenomenon?

2018

View full text Add to dashboard Cite

show abstract

“…Many arboviruses circulate in Nigeria, yellow fever for example has caused large epidemics in the past ( Carey et al, 1972 ; Fagbami et al, 1976 ; Nasidi et al, 1989 , there are also serologic evidence of human infection with yellow fever, Dengue, West Nile and Zika virus ( Fagbami, 1979 ; Baba et al, 2013 , Onoja et al, 2016 ). Antibodies to Rift Valley fever have been demonstrated in sera of humans and animals in Nigeria ( Olaleye et al, 1996a ; b ).…”

Section: Introductionmentioning

confidence: 99%

Influence of Meteorological Variables on Diversity and Abundance of Mosquito Vectors in Two Livestock Farms in Ibadan, Nigeria: Public Health Implications

Opayele

Adekunle

Tahiru

et al. 2017

jmr

View full text Add to dashboard Cite

This study was undertaken to determine mosquito vector diversity and abundance in two livestock farms with previous history of arboviral activities in Ibadan, southwestern Nigeria. The influence of weather on mosquito populations was also studied. Adult mosquitoes were collected weekly in two proximate University of Ibadan livestock farms from March 2015 to February 2016 using CO2 baited CDC light trap and human landing collection methods. Mosquitoes were identified to species using morphological keys. Relationships and interaction of temperature, relative humidity, rainfall patterns and mosquito abundance were analysed using GENSTAT 4th edition. Among 6,195 adult mosquitoes collected, 16 species belonging to 5 genera were morphologically identified. Culex quinquefasciatus constituted the most abundant mosquito, representing 46.49% of all mosquitoes encountered. High abundance in mosquito population was noted in periods succeeding months with heavy rainfall, this is when arbovirus transmission risk is highest. A positive correlation was observed between relative humidity and abundance of Mansonia mosquitoes. This study shows the effect of weather on natural populations of mosquito vectors. The diverse mosquito species capable of transmitting arboviruses from animal reservoirs to human and animals in livestock farms and its environment in Ibadan, Nigeria was also revealed. There is need for intensive vector control strategies targeted at reducing mosquito populations and ultimately prevention of disease outbreaks.

show abstract

“…These mosquitoes and hence arboviruses, continue to spread across the world even into areas that they never existed before [3], [34]. Nigeria, an endemic country for dengue fever, is currently experiencing several outbreaks of yellow fever [35], [36]. Despite these threats, entomological studies continue to rely on standard morphological keys for vector identification, at the expense of molecular methods like the PCR [24], [26], [37].…”

Section: Discussionmentioning

confidence: 99%

A Simple PCR Assay for Discrimination of Dengue Vectors from Nsukka LGA, Nigeria

et al. 2020

View full text Add to dashboard Cite

Mosquitoes of Aedes species are vectors of several arboviral diseases which continue to be a major public health problem in Nigeria. This study among other things, morphologically identified Aedes mosquitoes collected from Nsukka LGA and used an allele specific PCR amplification for discrimination of dengue vectors. Larval sampling, BG-sentinel traps and modified human landing catches were used for mosquito sampling in two selected autonomous communities of Nsukka LGA (Nsukka and Obimo). A total of 124 Aedes mosquitoes consisting of five (5) different species were collected from April to June, 2019 in a cross-sectional study that covered 126 households, under 76 distinct geographical coordinates. Larvae was mainly collected from plastic containers 73% (n=224), metallic containers 14% (n=43), earthen pots 9% (n=29) and used car tyres 3% (n=9), reared to adult stage 69.35% (n=86), and all mosquitoes were identified using standard morphological keys. Five (5) Aedes mosquito species were captured; Aedes aegypti 83(66.94%), Aedes albopictus 33(26.61%), Aedes simpsoni (4.48%), Aedes luteocephalus (≤1%) and Aedes vittatus (≤1%). Nsukka autonomous community had higher species diversity than Obimo. Allele specific amplification confirmed dengue vectors, Aedes aegypti and Aedes albopictus species on a 2% agarose gel. Since the most recent re-emergence of arboviral diseases is closely associated with Aedes species, findings of this study, therefore, give further evidence about the presence of potential arboviral vectors in Nigeria and describe the role of a simple PCR in discriminating some. Further entomological studies should integrate PCR assays in mosquito vector surveillance.

show abstract

High rate of unrecognized dengue virus infection in parts of the rainforest region of Nigeria

Abstract: Detection of DENV IgM in a cross-section of febrile patients using ELISA to determine sero-prevalence in the rain forest region in West Africa.

Cited by 28 publications

References 38 publications

Elimination of Falciparum Malaria and Emergence of Severe Dengue: An Independent or Interdependent Phenomenon?

Elimination of Falciparum Malaria and Emergence of Severe Dengue: An Independent or Interdependent Phenomenon?

Influence of Meteorological Variables on Diversity and Abundance of Mosquito Vectors in Two Livestock Farms in Ibadan, Nigeria: Public Health Implications

A Simple PCR Assay for Discrimination of Dengue Vectors from Nsukka LGA, Nigeria

Contact Info

Product

Resources

About