High rates of antibodies against Toscana and Sicilian phleboviruses in common quail Coturnix coturnix birds

Abstract

IntroductionBirds are involved natural cycle of a number of vector-borne viruses in both rural and urban areas. Toscana (TOSV) and Sicilian (SFSV) phleboviruses are sandfly-borne viruses in the genus Phlebovirus that can cause diseases in human. However, there is limited information on the role of the birds in sandfly-borne phleboviruses natural cycle and reservoirs ofthese viruses remain unknown.MethodsIn this study, we analyzed Common Quail (Coturnix coturnix) sera from Spain to identify the seroprevalence of these two phleboviruses. We tested respectively, 106 and 110 quail serum against TOSV and SFSV from 2018, 2019, and 2021 from two locations in northern Spain with using virus neutralization test.ResultsWe identified high neutralizing antibody rates for SFSV (45.45%) and TOSV (42.45%) with yearly fluctuation.DiscussionThis is the first identification of SFSV and TOSV neutralizing antibodies in wild birds. High seroprevalence rates of TOSV and SFSV in quail birds raises the question whether birds have a role as amplifying hosts in the natural cycle of phleboviruses.

Do birds play a role in the transmission of Toscana virus? Initial isolation results from birds in northernmost Türkiye

“…Considering TOSV has significant public health implications in Mediterranean countries, it is essential to find its reservoir or identify which organisms are involved in its transmission. Support for our findings come from Spain, where researchers detected seropositivity for TOSV (42.45%) from quail birds (Ayhan et al, 2023). These findings also indicate that birds may play a role in the TOSV transmission cycle.…”