High rates of serological response to a modified hepatitis B vaccination schedule in HIV-infected adults subjects

Increased Regulatory T Cell Counts in HIV‐Infected Nonresponders to Hepatitis B Virus Vaccine

“…Interestingly, antibody titers were dependent neither on HIV load levels nor on CD4 counts. Although HIV load levels are usually considered a good indicator of response to vaccine [33,34], the absence of association in our study could be explained, at least partially, on the basis of both the small sample size analyzed and the relatively low viral load of vaccinated subjects. In fact, only 7 of 40 subjects had HIV loads of 120,000 copies/mL, and only 3 of them had HIV loads 150,000 copies/mL.…”

Immune Response to Standard Hepatitis B Vaccination in HIV-Infected Patients

“…The lack of association between age or gender and HBV vaccine responsiveness was not unexpected which was in accordance with some previous studies [30,37]. The association between the HBV vaccine response rates and antiretroviral therapy and its duration has been shown in some studies [2,30]; however, other investigations have failed to establish a link between these variables and HBV vaccine seroprotection [32,38]. We also could not find the influence of antiretroviral therapy and its duration on the immune response rate to HBV vaccine.…”

Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients

“…Indeed, the assessment of these patients showed that 6 of them had active viral B infection (HBsAg positive and anti-HBcAb positive), 13 patients had past HBV infection with immunization status (HBsAg negative, anti-HBcAb and anti-HBs Ab positive) and 14 of them had past B virus infection with antiHBs Ab clearance (HBsAg negative, anti-HBcAb positive without anti-HBs Ab). Several studies showed that HBV vaccination efficiency depends on the immunity status of HIV-positive patients [30][31][32][33] . Therefore, there is a good correlation between CD4+ T-cell count and vaccinal response [30][31][32][33] .…”

“…Several studies showed that HBV vaccination efficiency depends on the immunity status of HIV-positive patients [30][31][32][33] . Therefore, there is a good correlation between CD4+ T-cell count and vaccinal response [30][31][32][33] . This aspect has never been studied in our context.…”