High recurrence rate in patients with juvenile-onset respiratory papillomatosis and its risk factors

Qu, Xiaoli; Xiao, Yang; Ma, Li; Niu, Zijie; Wang, Jun

doi:10.1007/s00405-022-07390-y

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…The Derkay score is a widely used assessment tool. A study examining 721 patients with juvenile-onset RRP reported that a high Derkay score was a risk factor for recurrence 27 . However, two limitations of the Derkay score are that the score cannot predict the site of recurrence, and the score could vary from evaluator to evaluator since no clear criteria exist for tumour size or other factors.…”

Section: Discussionmentioning

confidence: 99%

“…However, two limitations of the Derkay score are that the score cannot predict the site of recurrence, and the score could vary from evaluator to evaluator since no clear criteria exist for tumour size or other factors. Another well-known risk factor is the involvement of HPV type 11 [27][28][29] . In this study, the number of surgeries did not differ between HPV types 6 and 11; however, there was a statistically significant difference between HPV-positive and HPV-negative patients.…”

Section: Discussionmentioning

confidence: 99%

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Association between human papillomavirus particle production and the severity of recurrent respiratory papillomatosis

Yamada

Itoh

Ikegami

et al. 2023

Sci Rep

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Recurrent respiratory papillomatosis (RRP) has a wide range of severity. We investigate the relationship between human papillomavirus (HPV) particle production and severity of RRP. From September 2005 to June 2021, 68 RRP samples (from 29 patients) were included. HPV type was determined. HPV viral load, physical status, and demographic and clinical characteristics were assessed. Immunohistochemistry (IHC) was performed for p16, Ki-67, L1, and E4. We used NanoSuit-CLEM (correlative light and electron microscopy) and transmission electron microscopy (TEM) to examine the samples. The total number of surgeries in HPV-positive and HPV-negative cases were 3.78 (n = 55/68, range: 1–16) and 1.30 (n = 13/68, range: 1–3), respectively (p = 0.02). IHC showed that L1 and E4 were correlated and expressed on the tumour surface. NanoSuit-CLEM and TEM revealed HPV particles in L1-positive nuclei. L1 IHC-positive cases had a shorter surgical interval (p < 0.01) and more frequent surgeries (p = 0.04). P16 IHC, viral load, and physical status were not associated with disease severity. This study visualised HPV particle production in RRP for the first time. Persistent HPV particle infection was associated with severity. We suggest L1 IHC for evaluating RRP severity in addition to the Derkay score.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between human papillomavirus particle production and the severity of recurrent respiratory papillomatosis

Yamada

Itoh

Ikegami

et al. 2023

Sci Rep

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“…A greater effort should be made on HPV-immunization coverage, especially in developing countries where resources remain limited (2,6,8,18). This immunization is even more acritical as some observational studies suggest longer inter-surgical intervals and occasional remissions after vaccination (10,19).…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

“…Laryngeal papillomatosis is a rare but a serious etiology of laryngeal dyspnea, caused by human papillomavirus infection (90% from subtypes HPV-6 and HPV-11), acquired at birth from maternal genital warts, and due to benign tumors increasing gradually (2)(3)(4)(5). It is the most common benign laryngeal neoplasm in children and remains the second most common cause of childhood hoarseness (3)(4)(5)(6)(7)(8). It is generally described as juvenile because starting mainly in early childhood, and the worst outcome is observed in the youngest ages.…”

Section: Introductionmentioning

confidence: 99%

Juvenile laryngeal papillomatosis: a rare cause of upper airway obstruction with possible dysplasia

Sidatt¹,

Lehbib²,

Lemine³

et al. 2023

Pediatr Respir J

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Laryngeal papillomatosis is a rare and potentially severe cause of recurrent laryngeal dyspnea resistant to the usual treatments. It results from human papilloma virus (HPV) infection, transmitted M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o n during the perinatal period, and is mainly observed during the childhood. Upper airway obstruction is due to the growth of benign tumor, with rare malignant transformation. However, genetic mutation in association with viral integration can lead to the development and clonal expansion of malignant lesions. We report on one pediatric case of recurrent upper airway obstruction due to severe laryngeal papillomatosis with histological dysplasia. Through this case, the Authors emphasize the importance of early detection, close follow up, and appropriate treatment. They also call for increased HPV immunization coverage in low-income countries where medical resources are limited.IMPACT STATEMENT: Juvenile laryngeal papillomatosis is a rare but serious recurrent respiratory emergency with possible malignant transformation. Its management is challenging in low-income countries, and the HPV immunization is a promising measure.

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“…However, a third peak of incidence around 64 years was discovered by cross-sectional study [5] . In general, JO-RRP grows rapidly, and the lesions are often multifocal, and they are prone to recurrence after surgery [6] . Patients with AO-RRP are mostly localized, relatively slow-growing, and according to the available evidence, about 1-7% of cases will develop into squamous cell carcinoma [7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

Liu,

He,

et al. 2023

Preprint

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Objectives: Part I analyzes the clinical characteristics of JO-RRP and AO-RRP. Part II explores the influencing factors of surgical intervals. Methods: Part I: Clinical features were analyzed in 168 RRP patients (59 JO-RRP and 109 AO-RRP) diagnosed and treated in our hospital. Part II: The correlation of interoperative time with onset age, gender, Derkay anatomical score or surgical methods were analyzed in JO-RRP patients. Results: The interoperative time between operations in the JO-RRP group was 116.3±75.9 days, and in the AO-RRP group was 169.1±141.7 days (p<0.05). In the JO-RRP group, the CO2 laser treatment interval (186.2±140.1 days) was significantly longer than that of the microdebrider group (124.7±114.5 days) (p=0.011). Conclusions: 1. JO-RRP patients had higher Derkay score, higher surgical frequency and shorter surgical interval. 2. The surgical intervals lengthened with age and shortened with higher Derkay scores. CO2 laser surgery has the longest interoperative time.

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High recurrence rate in patients with juvenile-onset respiratory papillomatosis and its risk factors

Cited by 8 publications

References 26 publications

Association between human papillomavirus particle production and the severity of recurrent respiratory papillomatosis

Association between human papillomavirus particle production and the severity of recurrent respiratory papillomatosis

Juvenile laryngeal papillomatosis: a rare cause of upper airway obstruction with possible dysplasia

Characteristics of Recurrent Respiratory Papillomatosis and Impact Factors of Surgical Intervals

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