2006
DOI: 10.1038/sj.onc.1209570
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High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation

Abstract: The short arm of chromosome 8, 8p, is often rearranged in carcinomas, typically showing distal loss by unbalanced translocation. We analysed 8p rearrangements in 48 breast, pancreatic and colon cancer cell lines by fluorescence in situ hybridization (FISH) and array comparative genomic hybridization, with a tiling path of 0.2 Mb resolution over 8p12 and 1 Mb resolution over chromosome 8. Selected breast lines (MDA-MB-134, MDA-MB-175, MDA-MB-361, T-47D and ZR-75-1) were analysed further. Most cell lines showed … Show more

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Cited by 81 publications
(122 citation statements)
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“…The extent and complexity of chromosome 8p deletions suggests that various candidate TSGs are targeted (5,27,28). Here we have shown experimentally that cosuppression of linked 8p TSGs promotes tumor formation more potently than any individual gene.…”
Section: Discussionmentioning
confidence: 73%
“…The extent and complexity of chromosome 8p deletions suggests that various candidate TSGs are targeted (5,27,28). Here we have shown experimentally that cosuppression of linked 8p TSGs promotes tumor formation more potently than any individual gene.…”
Section: Discussionmentioning
confidence: 73%
“…Moreover, previous studies have shown that amplifications of 8p11-12, including the FGFR1 gene, are found in several tumor types, including for instance breast (Ugolini et al, 1999;Reis-Filho et al, 2006) and colorectal carcinomas (Nakao et al, 2004). Amplifications of the 8p11-12 region are often accompanied by loss of distal 8p, suggesting that one or more tumor suppressor genes are located on 8p (Pole et al, 2006). In three of our tumors with fusion and amplification, there was also a concomitant loss of 8p12-pter.…”
Section: Fgfr1-plag1 Gene Fusion and Amplification F Persson Et Almentioning
confidence: 81%
“…This is not the case in the IPH-926 cells, since they lack overexpression of FGFR1 mRNA and FGFR1 protein, and were not sensitive to the FGFR1 inhibitor SU5402. Genes such BAG4, C8orf4, and UNC5D might be the target of the genomic alterations on chromosome 8 [45,46].…”
Section: Discussionmentioning
confidence: 99%