High Resolution and High Contrast Bio-Medical X-ray Imaging Technique Using Synchrotron Radiation in PLS

Huang, Jung Yun; Jin, Kyeong-Sik; Lim, Jae Hong; Kim, H. Y.; Jang, Sang-Hun; Choi, Hyojin; Gil, Kyehwan; Lee, S. K.

doi:10.3938/jkps.56.2077

Cited by 5 publications

(3 citation statements)

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“…To provide insight into simulated betatron phase-contrast images, especially in the context of sub-micron resolution, we will consider a water droplet example containing two embedded virus particles. The water droplet is approximated as a uniform-density sphere of radius 20 µm, centered at (x = 0, y = 0), with a tabulated X-ray index of refraction 20 The two virus particles will be approximated as a uniform sphere of radius 200 nm, one centered at (x = 0, y = 0) and the other at various separation distances, with the index of refraction being different from water by ∆δ virus and ∆β virus . For example, a water droplet with a virus particle that is optically identical to water would be accounted for as a uniform droplet of index (δ water , β water ) and a relative virus contribution of ∆δ virus = ∆β virus = 0.…”

Section: Simulationsmentioning

confidence: 99%

Phase-contrast imaging with laser-plasma-accelerator betatron sources

Tilborg¹,

Ostermayr²,

Tsai³

et al. 2021

International Conference on X-Ray Lasers 2020

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Laser-plasma accelerators (LPAs) are known to intrinsically produce broad-bandwidth X-rays through the transverse motion of the accelerated electrons in the plasma wakefield. Due to the compact dimensions of the wakefield structure, this motion results in betatron radiation emission from a small point-like source (of order 1 µm in transverse size). Such a small source size enables high spatial resolution single-shot phase-contrast imaging, even for broad photon-energy spreads, simply by propagating the X-rays through a sample and onto a two-dimensional detector. In this manuscript we study, through simulations, the possibility to extend the resolution to the submicron regime. We find that the optimum geometry for <15 keV photons demands short (few-mm) drifts from source-to-sample, a photon flux of order 10 9 photons/shot, and the necessity to take the longitudinal source dimension into consideration. The presented framework behind the simulations will guide future betatron source development. The same expressions are also valid for other point-like LPA radiation sources such as Thomsonand Compton-scattered radiation.

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Section: Simulationsmentioning

confidence: 99%

Phase-contrast imaging with laser-plasma-accelerator betatron sources

Tilborg¹,

Ostermayr²,

Tsai³

et al. 2021

International Conference on X-Ray Lasers 2020

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“…This imaging mode can be applied to observe e.g. scattering signals from ultra-structures [31]. It is obvious that the distinct difference of Eq.…”

Section: Derivation Of Contrast Transfer Under Zernike Phase Contrastmentioning

confidence: 99%

Contrast transfer functions for Zernike phase contrast in full-field transmission hard X-ray microscopy

Yang¹,

Cheng²,

Heine³

et al. 2016

Opt. Express

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Full-field transmission hard X-ray microscopy (TXM) has been widely applied to study morphology and structures with high spatial precision and to dynamic processes. Zernike phase contrast (ZPC) in hard X-ray TXM is often utilized to get an in-line phase contrast enhancement for weak-absorbing materials with little contrast differences. Here, following forward image formation, we derive and simplify the contrast transfer functions (CTFs) of the Zernike phase imaging system in TXM based on a linear space-shift-invariant imaging mode under certain approximations. The CTFs in ZPC in their simplified forms show a high similarity to the one in free-space propagation X-ray imaging systems.

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“…The installation of white beam mode at any synchrotron beamline depends on its optical design, spectral distribution of the incident beam, heat load etc., and varies in the way by which these challenges are addressed for instrumental and personal safety. Some of the bending magnet beamlines with white beam mode of operation implemented are the Advanced Photon Source (APS), USA [2BM] (Wang et al, 2001), Pohang Light Source, South Korea [5C1] (Jung et al, 2002;Huang et al, 2010), Canadian Light Source, Canada [05B1-1] (Wysokinski et al, 2007), ANKA, Germany [TOPO-TOMO] (Rack et al, 2009), APS, USA [7-BM] (Rivers, 2016), Diamond Light Source, UK [B16] (Zhou et al, 2018), Elettra, Italy [SYRMEP] (Sena et al, 2015) etc. These beamlines offer a flux density of $10 12 photons s À1 mm À2 .…”

Section: Introductionmentioning

confidence: 99%

The white beam station at imaging beamline BL-4, Indus-2

et al. 2021

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The high flux density of synchrotron white beam offers several advantages in X-ray imaging such as higher resolution and signal-to-noise ratio in 3D/4D micro-tomography, higher frame rate in real-time imaging of transient phenomena, and higher penetration in thick and dense materials especially at higher energies. However, these advantages come with additional challenges to beamline optics, camera and sample due to increased heat load and radiation damage, and to personal safety due to higher radiation dose and ozone gas hazards. In this work, a white beam imaging facility at imaging beamline BL-4, Indus-2, has been developed, while taking care of various instrumental and personal safety challenges. The facility has been tested to achieve 1.5 µm spatial resolution, increased penetration depth up to 900 µm in steel, and high temporal resolutions of ∼10 ms (region of interest 2048 × 2048 pixels) and 70 µs (256 × 2048 pixels). The facility is being used successfully for X-ray imaging, non-destructive testing and dosimetry experiments.

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High Resolution and High Contrast Bio-Medical X-ray Imaging Technique Using Synchrotron Radiation in PLS

Cited by 5 publications

References 0 publications

Phase-contrast imaging with laser-plasma-accelerator betatron sources

Phase-contrast imaging with laser-plasma-accelerator betatron sources

Contrast transfer functions for Zernike phase contrast in full-field transmission hard X-ray microscopy

The white beam station at imaging beamline BL-4, Indus-2

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