High-resolution-cone beam tomography analysis of bone microarchitecture in patients with acromegaly and radiological vertebral fractures

Abstract

Editor-in-Chief: A. Giustina ▶ Covers leading topics in endocrinology ▶ Includes Hormones of reproduction, metabolism, growth, and ion balance ▶ Offers the latest on insulin and diabetes ▶ Presents newly-emerging endocrine-related topics ▶ 94% of authors who answered a survey reported that they would definitely publish or probably publish in the journal againWell-established as a major journal in today's rapidly advancing experimental and clinical research, Endocrine publishes full-length original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical (including proof of concept studies and clinical trials) research in all the different fields of endocrinology and metabolism. Endocrine covers the following leading topics in Endocrinology such as: Neuroendocrinology, Pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, type 1 and type 2 diabetes, hormones of male and female reproduction, and of HPA axis, pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.

MANAGEMENT OF ENDOCRINE DISEASE: Bone disorders associated with acromegaly: mechanisms and treatment

“…However, subsequent work demonstrated abnormalities in trabecular bone microstructure and strength in active acromegalic patientseven when gonadal function was normal (84,85,86). In addition to these changes in cancellous bone, the cortical bone compartment is affected, and GH excess is associated with increased cortical porosity/pore volume (81,84,87) and decreased cortical density (85).…”

“…VFs are not a simple radiological finding but they should be considered a marker of skeletal fragility, since an association between fractures and abnormalities in bone microstructure was found following the analysis of bone samples from individuals with acromegaly by histomorphometry, tridimensional dual-energy X-ray absorptiometry (DXA) of the proximal femur and peripheral HR-QCT of the bone structure at the distal radius (81,85,87).…”

Hip Structure Analyses in Acromegaly: Decrease of Cortical Bone Thickness After Treatment: A Longitudinal Cohort Study

“…Simultaneous alterations of both cortical and trabecular alterations have been demonstrated in early histomorphologic studies . Bone turnover is increased in acromegaly; accordingly, cortical porosity has been found increased in patients with active disease and vertebral fractures, partly explaining the discrepancy between bone mass and strength. An association between cortical thickness in the hip and vertebral fractures was recently demonstrated .…”

Pathophysiology of Growth Hormone Secretion Disorders and Their Impact on Bone Microstructure as Measured by Trabecular Bone Score

“…Patients with acromegaly have elevated bone turnover markers (Stepan et al 1979, Scillitani et al 1997, Ueland et al 2001 but BMD as measured by DXA may not adequately estimate fracture risk (Mazziotti et al 2015). Several quantitative computed tomography studies in acromegaly patients found poorer trabecular bone parameters, such as higher trabecular separation and decreased trabecular number and bone volume to tissue volume, in comparison to healthy controls (Maffezzoni et al 2016). These conclusions are supported by studies with bone microidentation (Malgo et al 2017) and TBS (Godang et al 2016, Hong et al 2016.…”