In arid and hyper‐arid zones, groundwater exploration is one of the most significant ways to locate potential new water supplies. Geophysical prospecting is currently the most successfully used method for locating new supplies, but it is rather costly. Satellite remote sensing (RS) detection, however, with its integration of Geographic Information Systems (GIS) provides the best chance for identifying and initially evaluating water‐bearing formations. In the western part of Saudi Arabia, Wadi Na'man has for centuries been one of the major water sources for the city of Makkah Al‐Mukarramah. It is therefore very important to find appropriate groundwater potential (GP) zones in this wadi for water supply. This study utilizes RS and GIS techniques, and also studies the hydrogeological, geological, and geomorphological characteristics that have significant impact on groundwater occurrence in Wadi Na'man. Representative layers are generated for each component and each given a weight ratio that depends on the level of influence. The overlay and integration of these thematic layers was used to produce a map that shows the most promising potential groundwater areas and classifies local potentials as either low, medium, or high. The results also reveal that the areas overall‐rated as “promising” (i.e., classified as medium or high) represent approximately 17‐25% of the total basin area and consist mainly of Quaternary sediments and connected fractured rock areas.