High-resolution images in macular disorders

Ochinciuc, Radu; Ochinciuc, Uliana; Baltă, George; L, Al Barri; Pac, C.; Adrian, Tari; Baltă, Florian; Burcea, Marian

doi:10.22336/rjo.2021.41

Cited by 3 publications

(3 citation statements)

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“…In regions of complete macular atrophy, AOSLO showed bright oversaturated areas where cones were not seen, consistent with SD-OCT scans revealing extensive loss in the outer retinal layers [2]. In AOSLO imaging of a female with STGD, there was a lack of cone mosaic with visible RPE cells in the atrophic zone, blurred cone mosaic, and reduced visibility of photoreceptors with some areas of the starrynight cone pattern in increased FAF peri-atrophic areas and normal cone mosaic in normal FAF peri-atrophic area along with decreased cone density from the center to peripheral retina [62]. In a study on 14 cases of clinically diagnosed STGD, Razeen et al suggested that compared to ONL, EZ, or IZ integrity assessment in OCT cone density measures by AO had a stronger correlation with retinal functional.…”

Section: Macular Dystrophies 431 Stargardt Diseasesupporting

confidence: 72%

“…Comparing findings from OCT, FAF, and AOSLO in a patient with RP, three types of cone mosaic phenotypes were described: normal cone mosaic in the center of the fovea, blurred cone mosaic ring in the parafoveal area with rapid deterioration of the cone mosaic from the inner to the outer edge of the ring, and cone disappearance with visible RPEs. A dramatic decrease in cone density was observed while the density at the blurred ring area was impossible to determine [62]. Gale and colleagues reported AOFIO findings in 39 patients with RP using the rtx1 camera and described four stages of cone degeneration [63].…”

Section: Rod-dominated Dystrophiesmentioning

confidence: 99%

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Pearls and Pitfalls of Adaptive Optics Ophthalmoscopy in Inherited Retinal Diseases

et al. 2023

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Adaptive optics (AO) retinal imaging enables individual photoreceptors to be visualized in the clinical setting. AO imaging can be a powerful clinical tool for detecting photoreceptor degeneration at a cellular level that might be overlooked through conventional structural assessments, such as spectral-domain optical coherence tomography (SD-OCT). Therefore, AO imaging has gained significant interest in the study of photoreceptor degeneration, one of the most common causes of inherited blindness. Growing evidence supports that AO imaging may be useful for diagnosing early-stage retinal dystrophy before it becomes apparent on fundus examination or conventional retinal imaging. In addition, serial AO imaging may detect structural disease progression in early-stage disease over a shorter period compared to SD-OCT. Although AO imaging is gaining popularity as a structural endpoint in clinical trials, the results should be interpreted with caution due to several pitfalls, including the lack of standardized imaging and image analysis protocols, frequent ocular comorbidities that affect image quality, and significant interindividual variation of normal values. Herein, we summarize the current state-of-the-art AO imaging and review its potential applications, limitations, and pitfalls in patients with inherited retinal diseases.

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Section: Macular Dystrophies 431 Stargardt Diseasesupporting

confidence: 72%

Section: Rod-dominated Dystrophiesmentioning

confidence: 99%

Pearls and Pitfalls of Adaptive Optics Ophthalmoscopy in Inherited Retinal Diseases

et al. 2023

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“…Most of the time, the disease does not require treatment, the patients being kept under observation by monitoring visual acuity and performing optical coherence tomography (OCT) of the macula. The most recent publications suggest a significant loss of photoreceptors even in patients whose visual acuity is not significantly affected after remission or treatment of the disease [1,2]. According to these results, each of the patients with CSC should be treated to prevent significant loss of cones at the level of the macula.…”

Section: Introductionmentioning

confidence: 99%