High-Resolution Imaging of Gunn's Dots

Pâques, M.; Miloudi, Chahira; Kulcsár, Caroline; Leseigneur, Alexandre; Chaumette, Céline; Koch, Edouard

doi:10.1097/iae.0000000000000269

Cited by 13 publications

(15 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26 They can appear as disc-shaped collagenous membranes covering the fovea, or may form a ring along the foveal margin, or may develop a cyst-like structure. 31,32 In contrast to Nakamura et al, 28 Gandorfer et al 30 attributed the hyperreflective knobs, detected with SD-OCT and identified after incomplete ILM peeling in eyes with macular holes, to remnants of vitreous fibrils adherent to the basal lamina of the ILM and not fibroproliferation of the ILM. In young patients, persistence of the posterior hyaloid or vitreous remnants may explain the presence of hyperreflective dots in the absence of a PVD.…”

Section: Discussionmentioning

confidence: 97%

“…In young patients, persistence of the posterior hyaloid or vitreous remnants may explain the presence of hyperreflective dots in the absence of a PVD. 31 Paques et al 32 described Gunn dots using en face adaptive optics and speculated that these either represented Müller cell end feet or vitreous hyalocytes. However, the unique location in the foveola, the larger dimension, the three-dimensional appearance on B-scan, and the absent detection on fundoscopy indicate that the hyperreflective dots identified in our study are not Gunn dots.…”

Section: Discussionmentioning

confidence: 99%

“…However, the unique location in the foveola, the larger dimension, the three-dimensional appearance on B-scan, and the absent detection on fundoscopy indicate that the hyperreflective dots identified in our study are not Gunn dots. 32 A bright light reflex off the foveal pit has been described, and this phenomenon may be more evident in eyes with a wider foveal pit. 32,33 This is unlikely to explain the multitude of hyperreflective dots especially remarkable in older patients, nor does it explain the progressive systematic increase correlated with age.…”

Section: Discussionmentioning

confidence: 99%

“…32 A bright light reflex off the foveal pit has been described, and this phenomenon may be more evident in eyes with a wider foveal pit. 32,33 This is unlikely to explain the multitude of hyperreflective dots especially remarkable in older patients, nor does it explain the progressive systematic increase correlated with age. 33,34 Furthermore, the en face hyperreflective dots were also identified with the registered structural OCT B-scan as elevated lesions, often with a distinct shape and morphology, therefore decreasing the likelihood that these dots are simply a foveal light reflex phenomenon.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Analysis of Hyperreflective Dots Within the Central Fovea in Healthy Eyes Using En Face Optical Coherence Tomography

Corradetti

Borrelli

et al. 2019

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

The purpose of this retrospective study was to describe and quantify superficial hyperreflective dots within the central fovea and correlate them with age, using en face and cross-sectional B-scan optical coherence tomography (OCT). METHODS. Healthy eyes, evaluated with a spectral domain instrument (primary cohort) at the Stein Eye Institute (UCLA) and with a swept source instrument (secondary cohort) at the Vitreous Retina Macula Consultants of New York, were included in this study. En face OCT images (3 3 3 mm) segmented at the level of the superior vascular plexus were acquired, and hyperreflective dots in the foveal avascular zone were quantified by two different methodologies. The threshold reflectivity methodology quantified these dots on a cropped en face OCT image using ellipsoid zone mean reflectivity as the threshold cutoff. The OCT B-scan methodology consisted of a manual count of elevated hyperreflective signals on B-scans that colocalized with the dots by en face OCT. Primary outcome was to quantify these dots and correlate them with age. RESULTS. A total of 44 healthy eyes were evaluated in the primary cohort, and 16 healthy eyes were evaluated in the secondary cohort. The hyperreflective dots steadily increased in number, especially in patients older than 50 years of age, with a strongly positive statistical significant correlation, using both quantitative strategies. CONCLUSIONS. Remarkable superficial hyperreflective dots in the central fovea of healthy subjects are novel anatomical findings that may be readily identified with both en face and cross-sectional OCT and steadily increase in number with age. We propose that these dots may represent a normal anatomical landmark, such as Müller cell end feet or inner limiting membrane basal lamina.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of Hyperreflective Dots Within the Central Fovea in Healthy Eyes Using En Face Optical Coherence Tomography

Corradetti

Borrelli

et al. 2019

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Accordingly, it has been shown that extracting the asymmetric component of photoreceptor reflectance (split-detection 27 ) is a powerful means for the identification of cones in a dystrophic retina. The Henle fibers, [28][29][30] the nerve fiber layer, 31 and Gunn's dots 32 also show strong directional reflectance; hence, multiangle imaging appears as a necessary procedure for adequate interpretation of high-resolution retinal imaging.…”

Section: Discussionmentioning

confidence: 99%

The Negative Cone Mosaic: A New Manifestation of the Optical Stiles-Crawford Effect in Normal Eyes

Miloudi

Rossant

Bloch

et al. 2015

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

PURPOSE. The purpose of this study was to describe a previously unreported manifestation of the optical Stiles-Crawford effect (oSCE) in normal eyes. METHODS.In a cohort of 50 normal subjects, the directional reflectance of cones in the retinal periphery was explored by flood-illuminated adaptive optics (FIAO) and optical coherence tomography (OCT). RESULTS.In 32 eyes (64%), off-axis FIAO images of the retinal periphery (~15-208 from the fovea) showed variably sized patches of hyporeflective dots (called here negative mosaic) coexisting with hyperreflective (positive) cones. In nine cases, shifting the entry pupil toward the optical axis restored the positive cone mosaic, with a point-by-point correspondence between positive and negative mosaics. Rods remained hyperreflective around negative and positive cones. These changes were paralleled by changes of the OCT reflectance of the cone outer segment tips and, to a lesser extent, of the inner/outer segment limit.CONCLUSIONS. By en face FIAO imaging of the retina, the contrast of cones over rods may be strongly dependent on the entry pupil to such an extent that their reflectance is lower than that of rods. We hypothesized that the negative cone mosaic aspect results from the differential Stiles-Crawford effect of cones and rods. Cone reflectance by en face FIAO parallels the reflectance from the cone outer segment tip line and to a lesser extent of the inner/outer segment limit by OCT. Taking this into account, the oSCE is of importance for the interpretation of high-resolution images of photoreceptors. (ClinicalTrials.gov number, NCT01546181.)

show abstract