High-Resolution Imaging of Photoreceptors in Macular Microholes

Ooto, Sotaro; Hangai, Masanori; Takayama, Kohei; Ueda-Arakawa, Naoko; Makiyama, Yukiko; Hanebuchi, Masaaki; Yoshimura, Nagahisa

doi:10.1167/iovs.13-13792

Cited by 11 publications

(4 citation statements)

References 55 publications

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“…This case also illustrates the subtle abnormality that may persist in the ellipsoid zone after healing of the laser injury. Such a lesion mimics previously described macular microholes . However, increased cone signal within the region of outer retinal lamellar defect has not been described before.…”

supporting

confidence: 82%

Structure‐function correlation and natural history of accidental juxtafoveal injury from a 250 milliwatt recreational hand‐held green laser device

Chew

Bukowska

Chen

2015

Clinical Exper Ophthalmology

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supporting

confidence: 82%

Structure‐function correlation and natural history of accidental juxtafoveal injury from a 250 milliwatt recreational hand‐held green laser device

Chew

Bukowska

Chen

2015

Clinical Exper Ophthalmology

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“…4 Various studies have reported that they can occur either with or without vitreomacular tractional interactions. In their study investigating 14 macular microholes, Ooto et al 5 reported that 64% of the eyes (9 eyes) exhibited complete or incomplete PVD, while 36% (5 eyes) showed no signs of PVD or vitreous traction. They suggested the possibility of a primary pathology in this group of microholes that may arise in the photoreceptor layer.…”

Section: Discussionmentioning

confidence: 99%

Vitreomacular Traction and Outer Retinal Structural Changes

Yıldırım

Menteş

Barış³

2019

tjo

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In this case report we aimed to present the outer retinal structural changes secondary to vitreomacular traction (VMT). Outer retinal structural changes occurring secondary to VMT due to incomplete posterior vitreous detachment were described retrospectively with spectral-domain optical coherence tomography in 3 eyes of 3 patients. The patients ranged in age from 58 to 65 years and best corrected visual acuity in the 3 eyes was 4/10, 8/10, and 9/10. All of the patients were symptomatic and exhibited outer retinal microholes at the fovea extending from the retinal pigment epithelium to outer limiting membrane, with an overlying operculum on the detached posterior hyaloid membrane over the macula following spontaneous resolution of VMT. In the mean follow-up period of 32 months, the outer retinal microholes decreased in size but did not completely resolve. As demonstrated in these cases, VMT can cause small outer retinal layer defects without signs of full-thickness macular hole. These lesions can cause symptoms and affect visual function, and may be permanent structural changes.

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“…However, the cone-rich rim and the foveola differ, and quite significantly, i.e., the photoreceptor outer segments in the cone-rich rim are tiny or absent [ 85 ], while the outer segments of central foveolar cones are approximately twice as long as those of parafoveal cones [ 86 ]. However, ocular coherence tomography (OCT) examination frequently reveals that disruption of the ellipsoid zone is restricted in the foveolar region in various macular diseases, such as a macular microhole, acute retinal pigment epitheliitis, and laser-induced maculopathy [ 87 , 88 , 89 ], and OCT images of these lesions are at least partly regarded as a loss of cone outer segments [ 90 ].…”

Section: Discussionmentioning

confidence: 99%

Blastocyst-like Structures in the Peripheral Retina of Young Adult Beagles

Ikeda,

Jin,

Takai

et al. 2024

IJMS

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In this immunohistological study on the peripheral retina of 3-year-old beagle dogs, excised retina specimens were immunostained with antibodies against nestin, Oct4, Nanog, Sox2, CDX2, cytokeratin 18 (CK 18), RPE65, and YAP1, as well as hematoxylin and DAPI, two nuclear stains. Our findings revealed solitary cysts of various sizes in the inner retina. Intriguingly, a mass of small round cells with scant cytoplasms was observed in the cavity of small cysts, while many disorganized cells partially occupied the cavity of the large cysts. The small cysts were strongly positive for nestin, Oct4, Nanog, Sox2, CDX2, CK18, and YAP1. RPE65-positive cells were exclusively observed in the tissue surrounding the cysts. Since RPE65 is a specific marker of retinal pigment epithelial (RPE) cells, the surrounding cells of the peripheral cysts were presumably derived from RPE cells that migrated intraretinally. In the small cysts, intense positive staining for nestin, a marker of retinal stem cells, seemed to indicate that they were derived from retinal stem cells. The morphology and positive staining for markers of blastocyst and RPE cells indicated that the small cysts may have formed structures resembling the blastocyst, possibly caused by the interaction between retinal stem cells and migrated RPE cells.

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High-Resolution Imaging of Photoreceptors in Macular Microholes

Abstract: Cone disruption occurs in eyes with macular microholes and a larger cone disruption area translates into a poorer visual acuity. Macular microholes, which are commonly observed as foveal cone inner and outer segment disruptions, may occur in eyes with or without vitreofoveal traction.

Cited by 11 publications

References 55 publications

Structure‐function correlation and natural history of accidental juxtafoveal injury from a 250 milliwatt recreational hand‐held green laser device

Structure‐function correlation and natural history of accidental juxtafoveal injury from a 250 milliwatt recreational hand‐held green laser device

Vitreomacular Traction and Outer Retinal Structural Changes

Blastocyst-like Structures in the Peripheral Retina of Young Adult Beagles

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