High Resolution Imaging of Viscoelastic Properties of Intracranial Tumours by Multi-Frequency Magnetic Resonance Elastography

Reiss-Zimmermann, M; Streitberger, Kaspar-Josche; Sack, Ingolf; Braun, Jürgen; Arlt, Felix; Fritzsch, Dominik; Hoffmann, Karl‐Titus

doi:10.1007/s00062-014-0311-9

Cited by 94 publications

(96 citation statements)

References 46 publications

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“…phase angle and loss tangent) have been shown to have the potential to distinguish meningiomas from glioblastomas, anaplastic astrocytomas, cerebral metastases and abscess in 27 patients with intracranial tumors (30). Perepelyuk et al also found that the ratio G ″/ G ′ (loss tangent) to be sensitive to very early onset of liver injury in an ex vivo CCl 4 mouse model (31).…”

Section: Discussionmentioning

confidence: 99%

Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography

et al. 2017

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Purpose To investigate the utility of Magnetic Resonance Elastography (MRE)-derived mechanical properties in discriminating hepatic inflammation and fibrosis in the early stages of chronic liver diseases. Material and Methods All studies were approved by our institutional animal care and use committee. A total of 187 animals were studied, including 182 mice and 5 pigs that represent five different liver diseases with a varying combination and extent of hepatic inflammation, fibrosis, congestion and portal hypertension. We performed multifrequency 3-D MRE with shear stiffness, storage and loss modulus, and damping ratio calculated in all animal subjects. Necroinflammation, fibrosis, and portal pressure were either histologically scored or bio-chemically/physically quantified in all studied animals. Two-sided Welch's t-tests were used to evaluate the mean differences between diseased and control/sham groups. Spearman's correlation analyses were used to evaluate the relationships between the mechanical parameters and the quantitative fibrosis extent (hydroxyproline concentration) and portal pressure. Results Liver shear stiffness and storage modulus increased with progressively developed fibrosis and portal hypertension (stiffness @80Hz, 48-week-feeding, steatohepatitis/controls, 0.51±0.12/0.29±0.01kPa, p=0.02). Damping ratio and loss modulus can distinguish inflammation from fibrosis at early stages, even before the development of histologically detectable necroinflammation and fibrosis (damping ratio @80Hz, 20-week-feeding, steatohepatitis/controls, 0.044±0.012 vs. 0.014±0.008, p<0.001). Damping ratio and shear stiffness vary differently with respect to etiology of portal hypertension (i.e., congestion or cirrhosis induced). These differentiation abilities have frequency-dependent variations. Conclusion Liver stiffness and damping ratio measurements can extend hepatic MRE to potentially assess necroinflammatory, congestive, and fibrotic processes of chronic liver diseases.

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Section: Discussionmentioning

confidence: 99%

Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography

et al. 2017

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“…One study reported that primary brain tumors have a uniform loss of dissipative behavior and that the tumor mechanical properties are altered with increasing malignancy 18 . Similarly, another study investigated the mechanical properties of GBMs using MRE and found that the majority of GBMs were softer than normal brain 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated the feasibility of using MRE to evaluate the viscoelastic properties of brain tumors including gliomas, where brain tumors were mainly softer than normal brain and benign variants, however some tumors are stiffer than normal brain 17 and GBMs were the softest brain tumors when compared to meningiomas, vestibular schwannomas, and metastases 18, 19 . Additional work demonstrated that viscoelastic properties of GBMs were dependent on composition (e.g., necrosis or cystic cavities) and that the mechanical properties were heterogeneous with both stiff and soft regions 17, 20 .…”

Section: Introductionmentioning

confidence: 99%

MR Elastography Analysis of Glioma Stiffness andIDH1-Mutation Status

Pepin¹,

McGee²,

Arani³

et al. 2017

AJNR Am J Neuroradiol

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Purpose To noninvasively evaluate gliomas with magnetic resonance elastography (MRE) to characterize the relationship of tumor stiffness with tumor grade and mutations in the IDH1 gene. Materials and Methods With institutional review board approval and following written, informed consent, tumor stiffness properties were prospectively quantified in 18 patients (mean age 42, 6 female) with histologically proven gliomas using MRE from 2014–2016. Images were acquired on a 3T MR unit with a vibration frequency of 60 Hz. Tumor stiffness was compared with unaffected contralateral white matter, across tumor grade and by IDH1 mutation status. The performance of the use of tumor stiffness to predict tumor grade and IDH1 mutation was evaluated by using Wilcoxon rank sum, one-way ANOVA and Tukey-Kramer tests. Results Gliomas were softer than healthy brain parenchyma, 2.2 kPa compared to 3.3 kPa (p < .0001) with grade IV tumors softer than grade II. Tumors with an IDH1 mutation were significantly stiffer than those with wild-type IDH1, 2.5 kPa vs. 1.6 kPa respectively (p = .007). Conclusions MRE demonstrated that gliomas were not only softer than normal brain but the degree of softening was directly correlated with tumor grade and IDH1 mutation status. Noninvasive determination of tumor grade and IDH1 mutation may result in improved stratification of patients for different treatment options and the evaluation of novel therapeutics. This work reports on the emerging field of mechanogenomics – the identification of genetic features such as IDH1 mutation using intrinsic biomechanical information.

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“…Although many of these studies have shown that tumors are stiffer than normal brain (Xu et al, 2007;Scholz et al, 2007Scholz et al, , 2005Chauvet et al, 2015), some have shown the opposite (Reiss- Zimmermann et al, 2015;Streitberger et al, 2014), and determination of stiffness differences between tumor grades has been inconclusive using this technique. Consistent with observations of stiffening of brain tumors, increased diffusion of water within a tumor, as measured by magnetic resonance imaging (MRI), is prognostic of poor outcome and is correlated with increased expression of ECM genes whose products are expected to stiffen a tissue (Pope et al, 2012(Pope et al, , 2009.…”

Section: Mechanical Properties Of Brain Tumor Subtypesmentioning

confidence: 99%

Tissue mechanics regulate brain development, homeostasis and disease

Barnes

Przybyla

Weaver

2017

Journal of Cell Science

270

245

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All cells sense and integrate mechanical and biochemical cues from their environment to orchestrate organismal development and maintain tissue homeostasis. Mechanotransduction is the evolutionarily conserved process whereby mechanical force is translated into biochemical signals that can influence cell differentiation, survival, proliferation and migration to change tissue behavior. Not surprisingly, disease develops if these mechanical cues are abnormal or are misinterpreted by the cells – for example, when interstitial pressure or compression force aberrantly increases, or the extracellular matrix (ECM) abnormally stiffens. Disease might also develop if the ability of cells to regulate their contractility becomes corrupted. Consistently, disease states, such as cardiovascular disease, fibrosis and cancer, are characterized by dramatic changes in cell and tissue mechanics, and dysregulation of forces at the cell and tissue level can activate mechanosignaling to compromise tissue integrity and function, and promote disease progression. In this Commentary, we discuss the impact of cell and tissue mechanics on tissue homeostasis and disease, focusing on their role in brain development, homeostasis and neural degeneration, as well as in brain cancer.

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High Resolution Imaging of Viscoelastic Properties of Intracranial Tumours by Multi-Frequency Magnetic Resonance Elastography

Cited by 94 publications

References 46 publications

Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography

Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography

MR Elastography Analysis of Glioma Stiffness andIDH1-Mutation Status

Tissue mechanics regulate brain development, homeostasis and disease

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