High‐Resolution Magnetic Resonance Imaging of Human Cochlea

Silver, Robert D.; Djalilian, Hamid R.; Levine, Samuel C.; Rimell, Frank L.

doi:10.1097/00005537-200210000-00005

Cited by 17 publications

(12 citation statements)

References 6 publications

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“…This phenomenon is very common at high field and indeed forms the basis for visualization of many structures whose physical size is subpixel, such as iron-loaded microglia and plaques in patients with Alzheimer disease. This phenomenon is supported by the findings of Silver et al, 5 who reported visualization of this structure at 9.4T MR imaging. We note that there are several discrepancies in this article with respect to the claimed spatial resolution, which does not agree with the image acquisition parameters in the "Materials and…”

supporting

confidence: 82%

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Jagt

Webb

Frijns

et al. 2014

AJNR Am J Neuroradiol

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supporting

confidence: 82%

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Jagt

Webb

Frijns

et al. 2014

AJNR Am J Neuroradiol

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“…In excised human (3) and animal (4,5) inner ear cadaveric samples, voxel resolutions of 32 3 43 3 49 lm , 58 3 58 3 300 lm 3 have been achieved at 9.4 T, 7 T, and 4.7 T, respectively. The highest reported resolution for in vivo human cochlear imaging is nearly 300 lm isotropic at 3T.…”

Section: Introductionmentioning

confidence: 99%

“…Gadolinium enhancement has been a primary tool for improving inner ear imaging both in cadaveric samples (3,9) and in vivo human studies (2,10). The cadaveric studies have achieved direct visualization of the vestibular (Reissner's) membrane, the thin partition separating the perilymph containing scala vestibule, and endolymph containing scala media (3,9).…”

Section: Introductionmentioning

confidence: 99%

“…The cadaveric studies have achieved direct visualization of the vestibular (Reissner's) membrane, the thin partition separating the perilymph containing scala vestibule, and endolymph containing scala media (3,9). Other internal structures of the cochlea, including the basilar membrane (which divides the scala tympani from the scala media and vestibuli) and modiolus, have been resolved in vivo on clinical 3T MR scanners (2,10).…”

Section: Introductionmentioning

confidence: 99%

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An improved RF and gradient coil system for high resolution in vivo guinea pig cochlea imaging on a 3T clinical magnet

Kaggie

Goodrich

Kim

et al. 2014

Concepts Magn Reson

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Purpose: The purpose of this work was to develop and evaluate a system consisting of an insertable gradient, RF coils, and animal positioning hardware to enable imaging of the internal structure of the cochlea and other inner ear structures of a guinea pig model at 3T.Methods: Transmit and receive RF coils, and an animal positioning system, were developed and integrated with an insertable gradient and animal monitoring system for improved guinea pig cochlea imaging when compared to a standard clinical 3T MRI system. A resolution phantom with 120 lm line separations was used to assess the contrast improvements with the insertable gradient. A homogeneous phantom was used to assess the SNR and homogeneity of the RF coils. FLASH imaging was used to observe the temporal passage of gadolinium contrast through the guinea pig cochlea. Results:The insertable gradient enabled increased resolution imaging with nearly twice the contrast-to-noise ratio. The small animal array had better SNR for imaging the guinea pig cochlea (about 14 mm deep) than the commercial Siemens wrist coil (2.23) and the small birdcage coil (1.63). The positioning device kept the animal secure and stationary. Injected gadolinium contrast allowed visualization of the internal cochlear structures with FLASH image acquisition, which achieved 100 lm isotropic resolution images in 33 min. Conclusion:The specialized RF coils and animal holding equipment designed to operate within the composite gradient enabled higher resolution images than could be obtained from the available RF coils operating in the conventional gradients on the clinical MRI system.

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“…While the latter can be seen routinely on CT images, visualizing the endolymphatic duct/vestibular aqueduct complex is extremely problematic, even where highest-resolution clinical MRI is used. Currently, ex vivo anatomic techniques are required to provide information on baseline images of the inner ear as seen on clinical high-resolution MRI scans [5]. By means of clinical imaging, pathology can at least be inferred from distortions of the above-mentioned landmarks.…”

mentioning

confidence: 99%

Some Remarks on Imaging of the Inner Ear: Options and Limitations

Giesemann

Hofmann

2015

Clin Neuroradiol

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The temporal bone has a highly complex anatomical structure, in which the sensory organs of the cochlea and the vestibular system are contained within a small space together with the sound-conducting system of the middle ear. Detailed imaging is thus required in this anatomical area. There are a great many clinical aims for which the highest-possible spatial resolution is required. These include the localization of cerebrospinal fluid fistulas, the detection of malformations of the middle and inner ear and the vestibulocochlear nerve, an aberrant course of the facial nerve and anomalies of the arterial and venous structures, the confirmation of dehiscence of the semicircular canals and finally, the verification of endolymphatic hydrops in cases of Ménière's disease. However, the term 'high resolution' is very time dependent. Two milestones in this respect have been (in 1991) the 3D visualization of the inner ear by means of maximum-intensity projection (MIP) of a T2-weighted constructive interference in steady state (CISS) sequence of a 1.5-tesla magnetic resonance imaging (MRI) scanner (Tanioka et al., Radiology 178:141-144, 1991) and (in 1997) imaging of the vestibulocochlear nerve for the diagnosis of hypoplasia inside the internal auditory canal using the same sequence (Casselman et al., Radiology 202:773-781, 1997).The objective of this article is to highlight the options for, and the challenges of, contemporary imaging with regard to some clinical issues relating to the inner ear.

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High‐Resolution Magnetic Resonance Imaging of Human Cochlea

Cited by 17 publications

References 6 publications

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An improved RF and gradient coil system for high resolution in vivo guinea pig cochlea imaging on a 3T clinical magnet

Some Remarks on Imaging of the Inner Ear: Options and Limitations

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