High-Resolution Magnetic Resonance Imaging: Three-Dimensional Trabecular Bone Architecture and Biomechanical Properties

Majumdar, Sharmila; Kothari, Mrityunjay; Augat, Peter; Newitt, David; Link, Thomas M.; Lin, John C.; Lang, Thomas; Lü, Ying; Genant, Harry K.

doi:10.1016/s8756-3282(98)00030-1

Cited by 306 publications

(198 citation statements)

References 46 publications

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“…While strong associations have been found between image-derived structural parameters on the one hand and elastic moduli and ultimate strength of TB on the other (125,157), these relationships are, nevertheless, empirical. In recent years, advances in 3D imaging of TB by m-CT and m-MRI, along with dramatic improvements in computing power, now permit large-scale finite-element (FE) computations of TB mechanical competence, thereby providing detailed information on local strain and failure behavior (158).…”

Section: Computational Biomechanicsmentioning

confidence: 97%

Quantitative MRI for the assessment of bone structure and function

et al. 2006

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Osteoporosis is the most common degenerative disease in the elderly. It is characterized by low bone mass and structural deterioration of bone tissue, leading to morbidity and increased fracture risk in the hip, spine and wrist-all sites of predominantly trabecular bone. Bone densitometry, currently the standard methodology for diagnosis and treatment monitoring, has significant limitations in that it cannot provide information on the structural manifestations of the disease. Recent advances in imaging, in particular MRI, can now provide detailed insight into the architectural consequences of disease progression and regression in response to treatment. The focus of this review is on the emerging methodology of quantitative MRI for the assessment of structure and function of trabecular bone. During the past 10 years, various approaches have been explored for obtaining image-based quantitative information on trabecular architecture. Indirect methods that do not require resolution on the scale of individual trabeculae and therefore can be practiced at any skeletal location, make use of the induced magnetic fields in the intertrabecular space. These fields, which have their origin in the greater diamagnetism of bone relative to surrounding marrow, can be measured in various ways, most typically in the form of R 0 2 , the recoverable component of the total transverse relaxation rate. Alternatively, the trabecular network can be quantified by high-resolution MRI (m-MRI), which requires resolution adequate to at least partially resolve individual trabeculae. Micro-MRI-based structure analysis is therefore technically demanding in terms of image acquisition and algorithms needed to extract the structural information under conditions of limited signal-to-noise ratio and resolution. Other requirements that must be met include motion correction and image registration, both critical for achieving the reproducibility needed in repeat studies. Key clinical applications targeted involve fracture risk prediction and evaluation of the effect of therapeutic intervention.

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Section: Computational Biomechanicsmentioning

confidence: 97%

Quantitative MRI for the assessment of bone structure and function

et al. 2006

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“…Parameters quantifying 3D connectivity [24,28], 3D anisotropy [29], and 3D irregularity [17,30] can be extracted from 3D images. These methods have been used to characterize cancellous bone from different sites [31][32][33][34]. Even if 3D images may now be provided from different techniques and modalities, it is worthwhile noting that spatial resolution strongly affects the accuracy of architectural parameters [35,36].…”

Section: Introductionmentioning

confidence: 99%

Relationship between compressive properties of human os calcis cancellous bone and microarchitecture assessed from 2D and 3D synchrotron microtomography

Follet

Bruyère-Garnier

Peyrin

et al. 2005

Bone

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The aim of this study was to determine the contribution of 2D and 3D microarchitectural characteristics in the assessment of the mechanical strength of os calcis cancellous bone. A sample of cancellous bone was removed in a medio-lateral direction from the posterior body of calcaneus, taken at autopsy in 17 subjects aged 61-91 years. The sample was first used for the assessment of morphological parameters from 2D morphometry and 3D synchrotron microtomography (ACT) (spatial resolution = 10 Am). The 2D morphometry was obtained from three slices extracted from the 3D ACT images. Very good concordance was shown between 3D ACT slices and the corresponding physical histologic slices. In 2D, the standard histomorphometric parameters, fractal dimension, mean intercept length, and connectivity were computed. In 3D, histomorphometric parameters were computed using both the 3D mean intercept length method and model-independent techniques. The 3D fractal dimension and the 3D connectivity, assessed by Euler density, were also evaluated. The cubic samples were subjected to elastic compressive tests in three orthogonal directions (X, Y, Z) close to the main natural trabecular network directions. A test was performed until collapse of trabecular network in the main direction (Z). The mechanical properties were significantly correlated to most morphological parameters resulting from 2D and 3D analysis. In 2D, the correlation between the mechanical strength and bone volume/tissue volume was not significantly improved by adding structural parameters or connectivity parameter (nodes number/tissue volume). In 3D, one architectural parameter (the trabecular thickness, Tb.Th) permitted to improve the estimation of the compressive strength from the bone volume/tissue volume alone. However, this improvement was minor since the correlation with the BV/TV alone was high (r = 0.96). In conclusion, which is in agreement with the statistic's rules, we found, in this study, that the determination of the os calcis bone compressive strength using the 3D bone volume fraction cannot be improved by adding 3D architectural parameters.

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“…Magnetic resonance imaging (MRI) provides unique capabilities for the study of the structural aspects of both trabecular and cortical bone, allowing in vivo, noninvasive, three-dimensional (3D) structure assessment without the use of ionizing radiation. Previous studies have demonstrated the usefulness of both high-resolution imaging (HR-MRI) [1][2][3][4][5][6] and MR relaxometry [7][8][9][10][11] for deriving structural parameters for the assessment of trabecular bone. For the current study we are concerned with HR-MRI, in which the trabecular structure is determined indirectly from a scan in which the bone marrow shows as a high intensity and the signal voids are assumed to be volumes of bone.…”

Section: Introductionmentioning

confidence: 99%