High-resolution metabolomics of exposure to tobacco smoke during pregnancy and adverse birth outcomes in the Atlanta African American maternal-child cohort

Tan, Youran; Barr, Dana Boyd; Ryan, P. Barry; Fedirko, Veronika; Sarnat, Jeremy A.; Gaskins, Audrey J.; Chang, Che-Jung; Tang, Ziyin; Marsit, Carmen J.; Corwin, Elizabeth J.; Jones, Dean P.; Dunlop, Anne L.; Liang, Donghai

doi:10.1016/j.envpol.2021.118361

Cited by 24 publications

(17 citation statements)

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“…The copyright holder for this preprint this version posted April 25, 2023. ; https://doi.org/10.1101/2023.04.24.23289055 doi: medRxiv preprint acids, and many of them have been linked to diet [12][13][14][15][16] , physical activity [17][18][19] , smoking [20][21][22] , sleep [23][24][25][26] , obesity 27,28,45 , or composite lifestyles scores [46][47][48][49] in previous studies. For example, (2,4 or 2,5)-dimethylphenol sulfate, tartronate, and ethyl beta-glucopyranoside are derived from plant-based foods; cotinine is the major metabolite of nicotine from tobacco smoking; cholesterol, sphingomyelin, cortisol, and 1-palmitoleoylglycerolare are related to blood lipids; mannose, metformin, and fructosyllysine are related to prevalent diabetes and blood glucose.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, circulating metabolites related to LE8 may capture varied individual metabolic responses to LE8, providing novel mechanistic insights into its cardioprotective effects and informing precision medicine. While previous studies have identified metabolites related to the components of LE8, including diet [12][13][14][15][16] , physical activity [17][18][19] , tobacco exposure [20][21][22] , sleep [23][24][25][26] , and body mass index (BMI) 27,28 , to our knowledge, no study has applied untargeted plasma metabolomics to identify a comprehensive metabolite signature (MetaSig) for LE8 to enable studies with incident CHD.…”

Section: Introductionmentioning

confidence: 99%

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Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease among Low-Income Black and White Americans

Deng

Gupta

Shu

et al. 2023

Preprint

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Background and Aims: Life's Essential 8 (LE8) is a comprehensive construct of cardiovascular health. Yet, little is known about LE8 score, its metabolic correlates, and their predictive implications among Black Americans and low-income individuals. Methods: In a nested case-control study of coronary heart disease (CHD) among 598 Black and 596 White low-income Americans, we estimated LE8 score, conducted untargeted plasma metabolites profiling, and used elastic net with leave-one-out cross-validation to identify metabolite signature (MetaSig) of LE8. Associations of LE8 score and MetaSig with incident CHD were examined using conditional logistic regression. Mediation effect of MetaSig on the LE8-CHD association was also examined. The external validity of MetaSig was evaluated in another nested CHD case-control study among 598 Chinese adults. Results: Higher LE8 score was associated with lower CHD risk [standardized OR (95% CI)=0.61 (0.53-0.69)]. The identified MetaSig, consisting of 133 metabolites, showed strong correlation with LE8 score (r=0.61) and inverse association with CHD risk [OR (95% CI)=0.57 (0.49-0.65)], robust to adjustment for LE8 score and across participants with different sociodemographic and health status (ORs: 0.42-0.69; all P<0.05). MetaSig mediated a large portion of the LE8-CHD association: 53% (32%-80%) (P<0.001). Significant associations of MetaSig with LE8 score and CHD risk were found in validation cohort [r=0.49; OR (95% CI)=0.57 (0.46-0.69)]. Conclusions: Higher LE8 score and its MetaSig were associated with lower CHD risk among low-income Black and White Americans. Metabolomics may offer an objective and comprehensive measure of LE8 score and its metabolic phenotype relevant to CHD prevention among diverse populations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease among Low-Income Black and White Americans

Deng

Gupta

Shu

et al. 2023

Preprint

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“…Cardiomyopathy and skeletal muscle dysfunctions are apparent in taurine deficiency [ 40 ]. Furthermore, the metabolic perturbations were related to endogenous inflammation, vascular reactivity, lipid peroxidation processes, oxidative stress, and insulin actions [ 41 ]. Even though inflammatory reactions may lead to PTB, there are no reports about the mechanism of action and effects of metabolites on PTB.…”

Section: Discussionmentioning

confidence: 99%

Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening

Yan

et al. 2022

Reprod Biol Endocrinol

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Background Preterm birth (PTB) is the primary cause of infant morbidity and mortality. Moreover, previous studies have established that PTB is related to premature cervical ripening. However, the underlying mechanism remains to be elucidated. This study sought to identify differentially expressed metabolites and investigate their potential biological functions in PTB. Methods Pregnant C57BL/6 J mice were treated with either LPS or normal saline and cervical alterations before labor were detected by staining. Metabolic profiles in the plasma of PTB and control mice were examined through non-targeted metabonomics analyses, quantitative polymerase chain reaction and immunofluorescence staining were performed on human cervical smooth cells. Results The study demonstrated that the mRNA and protein levels of α-SMA, SM-22, and calponin in cervical smooth muscle cells of PTB mice were lower while OR was higher at both mRNA and protein levels compared to the CTL group. A total of 181 differentially expressed metabolites were analyzed, among them, 96 were upregulated, while 85 were downregulated in the PTB group. Differentially expressed metabolites may play a role in STAT3, RhoA, mTOR, TGF-β, and NK-κB signaling pathways. Furthermore, when treated with taurine, the levels of α-SMA and SM-22 in human cervical smooth muscle cells were elevated, whereas that of connexin-43 was decreased. Conclusion Our study highlighted the changes of metabolites in the peripheral blood changed prior to PTB and revealed that these differentially expressed metabolites might participate in the development of premature cervical ripening. Taurine was identified as an important metabolite may modulate human cervical smooth muscle cells. Our study provided new insights into the mechanism underlying premature cervical ripening in PTB.

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“…Specifically, while targeted metabolomic studies provide detail on a priori specified metabolites of exposure, untargeted HRM provides data on all metabolites noted in a given sample, some of which can be annotated. HRM has been previously used to understand metabolic perturbations associated with smoking cigarettes (Hsu et al, 2017; Tan et al, 2022), but has never been used to explore secondhand electronic cigarette exposure. HRM presents a unique opportunity to explore potential biomarkers of exposure.…”

Section: Introductionmentioning

confidence: 99%

Saliva and Exhaled Breath Condensate Correlate With Serum in 4-12-Year-Olds Exposed to Secondhand Electronic Cigarette Vapors: A Pilot Study

Rodriguez

Liang

Tchen

et al. 2023

Biological Research For Nursing

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Electronic cigarette use is highest among adults of child-bearing age. Many parents that use electronic cigarettes believe that secondhand exposure of electronic cigarette vapors for their children is not dangerous and is less harmful than secondhand exposure to traditional cigarette smoke. These beliefs may prompt excessive secondhand exposure to electronic cigarette vapors for their children. Little research has been done to document exposure in children. The traditional biological method of exposure detection is through a blood draw, which is difficult and undesirable in children. The purpose of this study was to assess the feasibility of using saliva and exhaled breath condensate as non-invasive biomatrices for detecting secondhand electronic cigarette vapor exposure in children. In this cross-sectionally designed study, we recruited 22 children exposed to electronic cigarette vapors and 26 non-exposed between the ages of 4–12 years. We compared metabolic features across three biomatrices, blood, saliva, and exhaled breath condensate. We noted moderate to strong pairwise, sample-specific, and feature-specific adjusted correlations. Annotated features associated with direct and secondhand electronic cigarette exposure were noted. These results demonstrate that less invasive biomatrices may be used to detect features associated with secondhand electronic cigarette vapor exposure in children.

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High-resolution metabolomics of exposure to tobacco smoke during pregnancy and adverse birth outcomes in the Atlanta African American maternal-child cohort

Cited by 24 publications

References 91 publications

Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease among Low-Income Black and White Americans

Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease among Low-Income Black and White Americans

Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening

Saliva and Exhaled Breath Condensate Correlate With Serum in 4-12-Year-Olds Exposed to Secondhand Electronic Cigarette Vapors: A Pilot Study

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