High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma

Sirin, Selma; Schlamann, Marc; Metz, K.; Bornfeld, Norbert; Schweiger, Bernd; Holdt, Markus; Temming, Petra; Schuendeln, Michael M.; Goericke, Sophia L.

doi:10.1007/s00234-015-1544-2

Cited by 25 publications

(20 citation statements)

References 46 publications

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“…By taking advantage of the good coil filling factor and non-isotropic sampling (e.g., thick slices), fine resolution images, approaching those in rodents, but in humans without sedation is possible using a cuedblinking procedure (Beenakker et al, 2013(Beenakker et al, , 2015Berkowitz et al, 2001;Berkowitz et al, 2013;Lindner et al, 2014;Sirin et al, 2015;Zhang et al, 2011). For example, we recently published human images collected at 58 mm axial resolution .…”

Section: Addressing Concerns About Memri and Mrimentioning

confidence: 97%

MRI of rod cell compartment-specific function in disease and treatment in vivo

Berkowitz

Bissig

Roberts

2016

Progress in Retinal and Eye Research

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Rod cell oxidative stress is a major pathogenic factor in retinal disease, such as diabetic retinopathy (DR) and retinitis pigmentosa (RP). Personalized, non-destructive, and targeted treatment for these diseases remains elusive since current imaging methods cannot analytically measure treatment efficacy against rod cell compartment-specific oxidative stress in vivo. Over the last decade, novel MRI-based approaches that address this technology gap have been developed. This review summarizes progress in the development of MRI since 2006 that enables earlier evaluation of the impact of disease on rod cell compartment-specific function and the efficacy of anti-oxidant treatment than is currently possible with other methods. Most of the new assays of rod cell compartment-specific function are based on endogenous contrast mechanisms, and this is expected to facilitate their translation into patients with DR and RP, and other oxidative stress-based retinal diseases.

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Section: Addressing Concerns About Memri and Mrimentioning

confidence: 97%

MRI of rod cell compartment-specific function in disease and treatment in vivo

Berkowitz

Bissig

Roberts

2016

Progress in Retinal and Eye Research

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“…Otherwise we would repeat imaging only if the patient develops changes concerning for an orbital lesion. While the sensitivity for detecting postlaminar disease is variable (50% in this study), it has been shown to improve with fat saturation [18] and surface coils [19], and MRI can reliably detect larger levels of invasion and orbital disease [20]. We found that in this very small cohort, there is no need to enucleate these patients if the intraocular disease can be controlled with therapy, and the nerve can be adequately and routinely imaged with B-scan ultrasound and MRI.…”

Section: Discussionmentioning

confidence: 99%

Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion

et al. 2017

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Background: The objective of this study is to evaluate the risk of optic nerve invasion associated with optic nerve obscuration at diagnosis or persisting during treatment. Methods: Retrospective review from 2011-2016 of patients with advanced retinoblastoma (Group D/E) with complete obscuration of the nerve at diagnosis and a second group of patients with persistent, complete obscuration throughout treatment. Results: Advanced retinoblastoma was diagnosed in 102 eyes of 86 patients. The optic nerve was obscured in 69 eyes (68%) at diagnosis. Of these, 30 (43%) underwent salvage therapy and 39 (57%) primary enucleation. Histopathologic analysis of primarily enucleated eyes showed 41% prelaminar and 15% postlaminar invasion. Four eyes in the salvage group demonstrated persistent nerve obscuration; 2 were subsequently enucleated without evidence of nerve invasion. Average follow-up was 23.5 months (range 1-62 months). Conclusions and Relevance: Optic nerve obscuration at diagnosis may be associated with postlaminar optic nerve invasion. While persistent, complete obscuration of the optic nerve by retinoblastoma during treatment is a poor prognostic sign for both globe salvage and vision, it does not appear, in this small cohort, to increase the risk of optic nerve invasion. With appropriate control of the intraocular tumor, these eyes can be salvaged.

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“…While fundoscopy and optical coherence tomography can study the disc portion with high resolution, the remaining 3 portions are less accessible and require imaging studies, including MR imaging, sonography, and CT. 5,6 In fact, MR imaging is superior due to its high soft-tissue resolution, the absence of ionizing radiation, and its high diagnostic accuracy as demonstrated by several studies evaluating the sensitivity of MR imaging compared with histopathologic examination in the detection of tumor invasion. [7][8][9] According to Chawla et al 7 and Schueler et al, 8 the MR imaging sensitivity in detecting optic nerve abnormality is 60%-75%, while its specificity is up to 90%. Indeed, the optic nerve has been studied in healthy individuals and in pathologic states using MR imaging, CT, sonography, and cross-sectional anatomy.…”

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confidence: 99%

Optic Nerve Measurement on MRI in the Pediatric Population: Normative Values and Correlations

Al‐Haddad¹,

Sebaaly²,

Tutunji³

et al. 2017

AJNR Am J Neuroradiol

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High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma

Abstract: High-resolution MRI is clinically valuable for the detection of metastatic, especially of advanced metastatic risk factors in children with retinoblastoma.

Cited by 25 publications

References 46 publications

MRI of rod cell compartment-specific function in disease and treatment in vivo

MRI of rod cell compartment-specific function in disease and treatment in vivo

Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion

Optic Nerve Measurement on MRI in the Pediatric Population: Normative Values and Correlations

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