High resolution myocardial magnetic resonance stress perfusion imaging at 3 T using a 1 M contrast agent

Klumpp, Bernhard; Seeger, Achim; Doesch, Christina; Doering, Joerg; Hoevelborn, Tobias; Krämer, Ulrich; Fenchel, Michael; Gawaz, Meinrad; Claussen, Claus D.; Miller, Stephan

doi:10.1007/s00330-009-1580-6

Cited by 8 publications

(9 citation statements)

References 36 publications

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“…In the case of normal myocardial perfusion a three-to five-fold increase of myocardial blood flow could be expected which was also confirmed for quantitative analysis using SPCMR in healthy volunteers (18,26). The assumption of globally impaired myocardial perfusion is supported by the fact, that the MPRI was significantly reduced at 1.76 AE 0.53 in false negative patients with 3-vessel CAD compared to 2.87 AE 1.26 (P < 0.05) in patients without CAD in our study group (18,19,23).…”

Section: Discussionsupporting

confidence: 85%

“…Mismatch of perfusion and viability imaging was rated as myocardial ischemia. To confirm a potential mismatch of perfusion and viability imaging, regional hypoperfusion at stress had to be classified larger in regard of its transmural extent or to affect at least one more segment of left ventricular myocardium, otherwise it was categorized as MI without stress-induced ischemia of viable myocardium (23).…”

Section: Mrimentioning

confidence: 99%

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Is the diagnostic yield of myocardial stress perfusion MRI impaired by three-vessel coronary artery disease?

et al. 2015

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Section: Discussionsupporting

confidence: 85%

Section: Mrimentioning

confidence: 99%

Is the diagnostic yield of myocardial stress perfusion MRI impaired by three-vessel coronary artery disease?

et al. 2015

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“…This may be explained by technical postprocessing challenges, especially in the relatively thin-walled RV compared with the LV. To overcome these challenges, we sought to perform at-rest and stress perfusion MR imaging during systole for each short-axis section to maximize the RV and LV wall thicknesses by using highspatial-resolution gradient-echo MR imaging ( 37,38 ). In addition, we recorded the mean value of both short-axis sections for each ventricle to minimize the infl uence of potential artifacts.…”

Section: Cardiac Imaging: Perfusion Mr Imaging In Patients With Pulmomentioning

confidence: 99%

Right and Left Ventricular Myocardial Perfusion Reserves Correlate with Right Ventricular Function and Pulmonary Hemodynamics in Patients with Pulmonary Arterial Hypertension

Vogel‐Claussen¹,

Skrok²,

Shehata³

et al. 2011

Radiology

108

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Purpose:To evaluate the relationships of right ventricular (RV) and left ventricular (LV) myocardial perfusion reserves with ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension (PAH) by using adenosine stress perfusion cardiac magnetic resonance (MR) imaging. Materials and Methods:This HIPAA-compliant study was institutional review board approved. Twenty-fi ve patients known or suspected to have PAH underwent right heart catheterization and adenosine stress MR imaging on the same day. Sixteen matched healthy control subjects underwent cardiac MR imaging only. RV and LV perfusion values at rest and at adenosine-induced stress were calculated by using the Fermi function model. The MR imaging-derived RV and LV functional data were calculated by using dedicated software. Statistical testing included KruskalWallis tests for continuous data, Spearman rank correlation tests, and multiple linear regression analyses. Results:Seventeen of the 25 patients had PAH: 11 with sclerodermaassociated PAH, and six with idiopathic PAH. The remaining eight patients had scleroderma without PAH. groups. There were signifi cant correlations between biventricular MPRI and both mean pulmonary arterial pressure (mPAP) (RV MPRI: r = 2 0.59, Bonferroni P = .036; LV MPRI: r = 2 0.79, Bonferroni P , .002) and RV stroke work index (RV MPRI: r = 2 0.63, Bonferroni P = .01; LV MPRI: r = 2 0.75, Bonferroni P , .002). In linear regression analysis, mPAP and RV ejection fraction were independent predictors of RV MPRI. mPAP was an independent predictor of LV MPRI. Conclusion:Biventricular vasoreactivity is signifi cantly reduced with PAH and inversely correlated with RV workload and ejection fraction, suggesting that reduced myocardial perfusion reserve may contribute to RV dysfunction in patients with PAH.q RSNA, 2010

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“…Owing to the shortening of data acquisition intervals in the cardiac cycle using multiple element receiver-coils and parallel imaging algorithms, the frequency and severity of dark rim artefacts can be reduced, and as such, false-positive results may be potentially reduced [95]. The use of 3-Tesla field strength has not only been shown to provide benefits with regard to SNR, CNR and the amplitude of the SI-time curve but also, and more importantly, a potential impact on the accuracy of first-pass myocardial perfusion results [96–99]. Cheng et al [98] reported an increase of 82% to 90% and 90% to 98% for sensitivity and specificity, respectively, when moving from 1.5 to 3 Tesla in an intra-individual comparative study of MR stress perfusion imaging for the detection of significant coronary artery lesions.…”

Section: Mri For Cad: “The One-stop-shop”?mentioning

confidence: 99%

MRI and CT in the diagnosis of coronary artery disease: indications and applications

et al. 2010

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In recent years, technical advances and improvements in cardiac computed tomography (CT) and cardiac magnetic resonance imaging (MRI) have provoked increasing interest in the potential clinical role of these techniques in the non-invasive work-up of patients with suspected coronary artery disease (CAD) and correct patient selection for these emerging imaging techniques. In the primary detection or exclusion of significant CAD, e.g. in the patient with unspecific thoracic complaints, and also in patients with known CAD or advanced stages of CAD, both CT and MRI yield specific advantages. In this review, the major aspects of non-invasive MR and CT imaging in the diagnosis of CAD will be discussed. The first part describes the clinical value of contrast-enhanced non-invasive CT coronary angiography (CTCA), including the diagnostic accuracy of CTCA for the exclusion or detection of significant CAD with coronary artery stenoses that may require angioplastic intervention, as well as potentially valuable information on the coronary artery vessel wall. In the second section, the potential of CT for the imaging of myocardial viability and perfusion will be highlighted. In the third and final part, the range of applications of cardiac MRI in CAD patients will be outlined.

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High resolution myocardial magnetic resonance stress perfusion imaging at 3 T using a 1 M contrast agent

Abstract: High resolution MMRSPI at 3 T using 1 M contrast agent under daily routine conditions provides reliable detection of stress-induced myocardial hypoperfusion with higher diagnostic accuracy than 1.5-T conditions.

Cited by 8 publications

References 36 publications

Is the diagnostic yield of myocardial stress perfusion MRI impaired by three-vessel coronary artery disease?

Is the diagnostic yield of myocardial stress perfusion MRI impaired by three-vessel coronary artery disease?

Right and Left Ventricular Myocardial Perfusion Reserves Correlate with Right Ventricular Function and Pulmonary Hemodynamics in Patients with Pulmonary Arterial Hypertension

MRI and CT in the diagnosis of coronary artery disease: indications and applications

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