This paper presents a comparative study of the enstrophy budget and mixed mass between two- and three- dimensional flows induced by Richtmyer-Meshkov instability (RMI). Specifically, the individual contributions to the enstrophy budget due to the production from baroclinicity and from vortex stretching (which vanishes in two-dimensional flow) are delineated. This is enabled by a set of two- and three-dimensional computations at Atwood 0:5 having both narrow- and broad-band perturbations. A further three dimensional computation is conducted at Atwood 0:9 using an identical narrowband perturbation to the Atwood 0.5 case to examine the sensitivity to density ratio. The mixed mass is also considered with the goal to obtain insight on how faithfully a simplified calculation performed in two dimensions can capture the mixed mass for an inertial confinement fusion (ICF) or other practical application. It is shown that the late time power law decay of variable density enstrophy is substantially different in two and three dimensions for the narrowband initial perturbation. The baroclinic production term is negligible in three dimensions (aside from the initial shock interaction), as vortex stretching is larger by two orders of magnitude. The lack of vortex stretching considerably reduces the decay rate in both narrowband and broadband perturbations in two dimensions. In terms of mixed mass, the lack of vortex stretching reduces the mixed mass in two dimensions compared to three in all cases. In the broadband cases, the spectral bandwidth in the two dimensional case is wider, hence there is a longer time period of sustained linear growth which reduces the normalised mixed mass further.