2020
DOI: 10.1101/2020.12.07.412700
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High-resolution radioluminescence microscopy of FDG uptake in an engineered 3D tumor-stoma model

Abstract: PURPOSEThe increased glucose metabolism of cancer cells is the basis for 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). However, due to its coarse image resolution, PET is unable to resolve the metabolic role of cancer-associated stroma, which often influences the metabolic reprogramming of a tumor. This study investigates the feasibility of imaging engineered 3D tumor models with high resolution using FDG.METHODMulticellular tumor spheroids (A549 lung adenocarcinoma) were co-cultured with GFP-… Show more

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