High Resolution Spectral Domain Optical Coherence Tomography (SD-OCT) in Multiple Sclerosis: The First Follow Up Study over Two Years

Serbecic, Nermin; Aboul‐Enein, Fahmy; Beutelspacher, Sven C.; Vass, Clemens; Kristoferitsch, Wolfgang; Lassmann, Hans; Reitner, Andreas; Schmidt‐Erfurth, Ursula

doi:10.1371/journal.pone.0019843

Cited by 56 publications

(55 citation statements)

References 33 publications

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“…Our results, however, are more in line with 2 other studies in which no significant decrease was observed in RNFL thickness during follow-up. 30,31 Discrepancies in RNFL change across studies may relate to differences in cohort characteristics. Our results raise the possibility that rates of RNFL thinning may be greater in cohorts with larger proportions of patients with prior ON.…”

Section: Results a Total Of 164 Ms/cis Patients (116 Rrms 24 Spms 1mentioning

confidence: 99%

Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning

et al. 2013

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Objective: To determine the effect of clinical and radiologic disease activity on the rate of thinning of the ganglion cell/inner plexiform (GCIP) layer and the retinal nerve fiber layer in patients with multiple sclerosis (MS) using optical coherence tomography (OCT).Methods: One hundred sixty-four patients with MS and 59 healthy controls underwent spectraldomain OCT scans every 6 months for a mean follow-up period of 21.1 months. Baseline and annual contrast-enhanced brain MRIs were performed. Patients who developed optic neuritis during follow-up were excluded from analysis.Results: Patients with the following features of disease activity during follow-up had faster rates of annualized GCIP thinning: relapses (42% faster, p 5 0.007), new gadolinium-enhancing lesions (54% faster, p , 0.001), and new T2 lesions (36% faster, p 5 0.02). Annual GCIP thinning was 37% faster in those with disability progression during follow-up, and 43% faster in those with disease duration ,5 years vs .5 years (p 5 0.003). Annual rates of GCIP thinning were highest in patients exhibiting combinations of new gadolinium-enhancing lesions, new T2 lesions, and disease duration ,5 years (70% faster in patients with vs without all 3 characteristics, p , 0.001).Conclusions: MS patients with clinical and/or radiologic nonocular disease activity, particularly early in the disease course, exhibit accelerated GCIP thinning. Our findings suggest that retinal changes in MS reflect global CNS processes, and that OCT-derived GCIP thickness measures may have utility as an outcome measure for assessing neuroprotective agents, particularly in early, active MS. The anterior visual pathway is frequently affected in multiple sclerosis (MS), with 94% to 99% of patients with MS demonstrating optic nerve lesions postmortem.

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Section: Results a Total Of 164 Ms/cis Patients (116 Rrms 24 Spms 1mentioning

confidence: 99%

Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning

et al. 2013

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“…Up till now, a reliable specific para-clinical marker neither for the diagnosis nor for monitoring disease activity of MS could yet be established (e.g. Aboul-Enein et al, 2010;Gilmore et al, 2010;Kuhle et al, 2007;Serbecic et al, 2010Serbecic et al, , 2011.…”

Section: Diagnostic Criteria and The Disease Course Of Msmentioning

confidence: 99%

MR Spectroscopy in Multiple Sclerosis - A New Piece of the Puzzle or Just a New Puzzle

Aboul‐Enein¹

2012

Magnetic Resonance Spectroscopy

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“…11 Serbecic et al prospectively studied 37 RRMS and secondary progressive MS patients on two occasions with a median interval of 22.4 AE 0.5 months and did not find any significant changes between the baseline and follow-up RNFL patterns. 12 Another study reported no significant change in RNFL over 2 years in 46 MS patients without comparative data from healthy controls. 18 These studies support our results of almost stable RNFL thickness in MS patients during relatively short follow-up period.…”

Section: Discussionmentioning

confidence: 97%

“…reduced over time. 11,12 Henderson et al studied 34 patients with progressive MS on two occasions with a median interval of 575 days and 18 healthy controls with a median interval of 656 days. The MS patients had significant decreases in the baseline RNFL thickness and macular volume of their clinically unaffected eyes compared with controls.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] On the other hand, some longitudinal studies found that RNFL thickness measured by OCT did not decrease significantly in MS patients during the follow-up period. 11,12 It is known that RNFL thickness of healthy individuals without any history of neurological or ocular disorders decrease over time. 13 In this research, our aim was to study RNFL and optic nerve head parameters in a cohort of relapsing-remitting (RRMS) subtype of MS patients without a history of prior ON and new clinical attack during the follow-up of 20 months in comparison with the healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

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Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

Huseyinoglu¹,

Özben²,

Ekinci

et al. 2013

Neuro-Ophthalmology

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Optical coherence tomography is supported and used as a technique for visualisation of neuro-axonal loss in multiple sclerosis, but there are also a few studies expressing the opposite view. The aim of our study was to investigate retinal nerve fibre layer and optic nerve head parameters in patients with multiple sclerosis without a history of prior optic neuritis and symptoms of a new clinical attack during the follow-up for a total of 20-month period. Full ophthalmic evaluation was performed for all of the participants. The baseline retinal nerve fibre layer and macular thicknesses and focal and global loss of macular volume values were significantly lower in the eyes of the patients with multiple sclerosis compared with the healthy controls. No significant change between baseline and follow-up scans were found in all optical coherence tomography parameters in the multiple sclerosis group. Statistical analyses revealed significant retinal nerve fibre layer and macular thickness differences between baseline and second measurements in the controls. No significant difference in percent change between baseline and second measurements was observed between the patient and control groups. We conclude that whereas healthy subjects have an age-related tendency toward a decrease in retinal nerve fibre layer thickness, patients with multiple sclerosis patients are likely to pass through different stages of retinal thinning and thickening due to subclinical optic neuritis and, as a result, we could not detect any statistically significant change between baseline and second measurements in our multiple sclerosis patients.

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High Resolution Spectral Domain Optical Coherence Tomography (SD-OCT) in Multiple Sclerosis: The First Follow Up Study over Two Years

Cited by 56 publications

References 33 publications

Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning

Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning

MR Spectroscopy in Multiple Sclerosis - A New Piece of the Puzzle or Just a New Puzzle

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

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