Introduction WC are developing low-tcmpaature detectors for optical, ultraviolet, X-ray, and gamma-ray spcctroscopy, and for biomolecular mass spcctromchy We present here a some of our recent work in dcveloping these detectors and some of the first rcsu1t.s in applying these detectors to X-ray fluorescence analysisWe have measured thin-film Nb/Al/Al~03/Al/Nb superconducting tunnel junction (STJ) X-ray detectors in the 0 2 to 1 kcV band with a range of different junction sizes and aluminum film thicknesses In one case, we have achieved the statistical limit to the energy resolution in this band We have measured the performance of these STJ detectors as a function of count rate. and demonstrated a resolution of 13 cV FWHM at 271 eV with an output count rate of 20,600 ctsls Using X rays from SSRL to study composite materials, we have demonstrated that wc can resolve the L lines of transition metals from the nearby K lines of light elements We describe the first use of a low-temperature X-ray detector to measure X-ray fluoresccncc from the dilute metal component in a protein