High resolution time-of-flight MR-angiography at 7 T exploiting VERSE saturation, compressed sensing and segmentation

Meixner, Christian; Liebig, Patrick; Speier, Peter; Forman, Christoph; Hensel, Bernhard; Schmidt, Manuel; Saake, Marc; Uder, Michael; Doerfler, Arnd; Heidemann, Robin M.; Schmitter, Sebastian; Nagel, Armin M.

doi:10.1016/j.mri.2019.08.014

Cited by 26 publications

(29 citation statements)

References 39 publications

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“…Further, inflow in large pial veins and the dural venous sinuses can lead to high image intensities in these venous structures, and, consequently, false positives in the segmentation and identification of pial arteries. While additional RF pulses ( Meixner et al, 2019 ; Schmitter et al, 2012 ) can be played out during image acquisition to suppress venous signal, the associated higher power deposition and increased acquisition times would reduce the imaging efficiency. Thus, we instead explored the removal of unwanted veins using a low-resolution two-echo TOF acquisition and

estimates to identify non-arterial vessels in the segmentation of the high-resolution data ( Bae et al, 2010 ; Deistung et al, 2009 ; Du et al, 1994 ; Du and Jin, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Bollmann

Mattern

Bernier

et al. 2022

eLife

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The pial arterial vasculature of the human brain is the only blood supply to the neocortex, but quantitative data on the morphology and topology of these mesoscopic arteries (diameter 50-300µm) remains scarce. Because it is commonly assumed that blood flow velocities in these vessels are prohibitively slow, non-invasive time-of-flight MRI angiography (TOF-MRA)-which is well-suited to high 3D imaging resolutions-has not been applied to imaging the pial arteries. Here, we provide a theoretical framework that outlines how TOF-MRA can visualize small pial arteries in vivo, by employing extremely small voxels at the size of individual vessels. We then provide evidence for this theory by imaging the pial arteries at 140-µm isotropic resolution using a 7T MRI scanner and prospective motion correction, and show that pial arteries one voxel-width in diameter can be detected. We conclude that imaging pial arteries is not limited by slow blood flow, but instead by achievable image resolution. This study represents the first targeted, comprehensive account of imaging pial arteries in vivo in the human brain. This ultra-high-resolution angiography will enable the characterization of pial vascular anatomy across the brain to investigate patterns of blood supply and relationships between vascular and functional architecture.

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estimates to identify non-arterial vessels in the segmentation of the high-resolution data ( Bae et al, 2010 ; Deistung et al, 2009 ; Du et al, 1994 ; Du and Jin, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Bollmann

Mattern

Bernier

et al. 2022

eLife

View full text Add to dashboard Cite

show abstract

“…Further, inflow in large pial veins and the dural venous sinuses can lead to high image intensities in these venous structures, and, consequently, false positives in the segmentation and identification of pial arteries. While additional radiofrequency pulses (Meixner et al, 2019; Schmitter et al, 2012) can be played out during image acquisition to suppress venous signal, the associated higher power deposition and increased acquisition times would reduce the imaging efficiency. Thus, we instead explored the removal of unwanted veins using a low-resolution two-echo TOF acquisition and estimates to identify non-arterial vessels in the segmentation of the high-resolution data (Bae et al, 2010; Deistung et al, 2009; Du et al, 1994; Du and Jin, 2008).…”

Section: Discussionmentioning

confidence: 99%

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Bollmann

Mattern

Bernier

et al. 2021

Preprint

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The pial arterial vasculature of the human brain is the only blood supply to the neocortex, but quantitative data on the morphology and topology of these mesoscopic vessels (diameter 50-300 μm) remains scarce. Because it is commonly assumed that blood flow velocities in these vessels are prohibitively slow, non-invasive time-of-flight MRI angiography (TOF-MRA)-which is well-suited to high 3D imaging resolutions-has not been applied to imaging the pial arteries. Here, we provide a theoretical framework that outlines how TOF-MRA can visualize small pial arteries in vivo, by employing extremely small voxels at the size of individual vessels. We then provide evidence for this theory by imaging the pial arteries at 140-μm isotropic resolution using a 7T MRI scanner and prospective motion correction, and show that pial arteries one voxel-width in diameter can be detected. We conclude that imaging pial arteries is not limited by slow blood flow, but instead by achievable image resolution. This study represents the first targeted, comprehensive account of imaging pial arteries in vivo in the human brain. This ultra-high-resolution angiography will enable the characterization of pial vascular anatomy across the brain to investigate patterns of blood supply and relationships between vascular and functional architecture.

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“…times, and not on the enhancement of spatial resolution [30,31]. Moreover, even 7T system shows a resolution of 0.23-0.31 mm 3 [4,34]. Therefore, further studies are necessary.…”

Section: Plos Onementioning

confidence: 98%

Added diagnostic values of three-dimensional high-resolution proton density-weighted magnetic resonance imaging for unruptured intracranial aneurysms in the circle-of-Willis: Comparison with time-of-flight magnetic resonance angiography

et al. 2020

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Background Advanced imaging methods can enhance the identification of aneurysms of the infundibula, which can reduce unnecessary follow-ups or further work-up, fear, and anxiety in patients. Purpose This study aimed to evaluate the added diagnostic value of three-dimensional proton density-weighted vessel wall magnetic resonance imaging (3D-PD MRI) in identifying aneurysms from index lesions refer to vascular bulging lesions without vessels arising from the apex, observed using volume-rendered TOF-MRA in the circle-of-Willis compared with time-of-flight magnetic resonance angiography (TOF-MRA). Study type Retrospective. Population A total of 299 patients who underwent 3D-PD MRI, digital subtraction angiography (DSA), and TOF-MRA between January 2012 and December 2016 were retrospectively enrolled in this study. Field strength/sequence 3 Tesla, 3D-PD MRI. Assessment Three neuroradiologists independently evaluated TOF-MRA and 3D-PD MRI combined with TOF-MRA for the determination of intracranial aneurysms in patients with index lesions within the circle of Willis. Final diagnoses were made by another neuroradiologist and neurointerventionist in consensus using DSA as the reference standard. The diagnostic performance and proportions of undetermined lesions on TOF-MRA and 3D-PD MRI with TOF-MRA were assessed based on the final diagnoses. Statistical tests The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for the diagnosis of unruptured intracranial aneurysms were calculated for each imaging modality. Results Of 452 lesions identified on volume-rendered TOF-MRA images, 173 (38%) aneurysms and 276 (61%) infundibula were finally diagnosed on DSA. 3D-PD MRI with TOF-MRA showed superior diagnostic performance (p = .001; accuracy, 85.5% versus 95.4%), superior area under the receiver operating characteristic curve over TOF-MRA (p = .001; 0.837 versus 0.947), and a lower proportion of undetermined lesions than TOF-MRA (p = .001; 25.1% versus 2.3%). Data conclusion For unruptured intracranial aneurysms in the circle of Willis, 3D-PD MRI can complement TOF-MRA to improve diagnostic performance and lower the proportion of undetermined lesions.

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High resolution time-of-flight MR-angiography at 7 T exploiting VERSE saturation, compressed sensing and segmentation

Cited by 26 publications

References 39 publications

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Added diagnostic values of three-dimensional high-resolution proton density-weighted magnetic resonance imaging for unruptured intracranial aneurysms in the circle-of-Willis: Comparison with time-of-flight magnetic resonance angiography

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High resolution time-of-flight MR-angiography at 7 T exploiting VERSE saturation, compressed sensing and segmentation

Cited by 26 publications

References 39 publications

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Added diagnostic values of three-dimensional high-resolution proton density-weighted magnetic resonance imaging for unruptured intracranial aneurysms in the circle-of-Willis: Comparison with time-of-flight magnetic resonance angiography

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High resolution time-of-flight MR-angiography at 7 T exploiting VERSE saturation, compressed sensing and segmentation