High-Resolution Whole-Body Magnetic Resonance Image Tumor Staging With the Use of Parallel Imaging Versus Dual-Modality Positron Emission Tomography–Computed Tomography

Schmidt, Gerwin P.; Baur‐Melnyk, Andrea; Herzog, Peter; Schmid, Rupert; Tiling, Reinhold; Schmidt, Michael; Reiser, Maximilian; Schoenberg, Stefan O.

doi:10.1097/01.rli.0000185878.61270.b0

Cited by 161 publications

(114 citation statements)

References 33 publications

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“…However, also a decreased SNR of images acquired with parallel imaging was shown, which limits the use of higher acceleration factors (R Ͼ 2) with standard coil geometry. This is also confirmed by recent publications on HASTE MRI of the lungs, which all have used the GRAPPA algorithm with an acceleration factor of R ϭ 2 (3,13,22,23).…”

Section: Discussionsupporting

confidence: 77%

Half‐fourier‐acquisition single‐shot turbo spin‐echo (HASTE) MRI of the lung at 3 Tesla using parallel imaging with 32‐receiver channel technology

Henzler

Dietrich

Krissak

et al. 2009

Magnetic Resonance Imaging

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Purpose:To assess the feasibility of half-Fourier-acquisition single-shot turbo spin-echo (HASTE) of the lung at 3 Tesla (T) using parallel imaging with a prototype of a 32-channel torso array coil, and to determine the optimum acceleration factor for the delineation of intrapulmonary anatomy. Materials and Methods:Nine volunteers were examined on a 32-channel 3T MRI system using a prototype 32-channeltorso-array-coil. HASTE-MRI of the lung was acquired at both, end-inspiratory and end-expiratory breathhold with parallel imaging (Generalized autocalibrating partially parallel acquisitions ϭ GRAPPA) using acceleration factors ranging between R ϭ 1 (TE ϭ 42 ms) and R ϭ 6 (TE ϭ 16 ms). The image quality of intrapulmonary anatomy and subjectively perceived noise level was analyzed by two radiologists in consensus. In addition quantitative measurements of the signalto-noise ratio (SNR) of HASTE with different acceleration factors were assessed in phantom measurements. Results:Using an acceleration factor of R ϭ 4 image blurring was substantially reduced compared with lower acceleration factors resulting in sharp delineation of intrapulmonary structures in expiratory scans. For inspiratory scans an acceleration factor of 2 provided the best image quality. Expiratory scans had a higher subjectively perceived SNR than inspiratory scans. Conclusion:Using optimized multi-element coil geometry HASTE-MRI of the lung is feasible at 3T with acceleration factors up to 4. Compared with nonaccelerated acquisitions, shorter echo times and reduced image blurring are achieved. Expiratory scanning may be favorable to compensate for susceptibility associated signal loss at 3T.

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Section: Discussionsupporting

confidence: 77%

Half‐fourier‐acquisition single‐shot turbo spin‐echo (HASTE) MRI of the lung at 3 Tesla using parallel imaging with 32‐receiver channel technology

Henzler

Dietrich

Krissak

et al. 2009

Magnetic Resonance Imaging

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“…One possible way to achieve this goal is through the use of parallel imaging, which is becoming clinically accessible but was not used in our current study because a phased array coil was only available for the torso sections. A complete body phased array coil matrix with WB coverage or integrated phased-array surface coil with specialized rolling table platform, which are available on some scanner systems (26,27), would make the use of parallel imaging a viable choice for reducing the overall scanning time. Since an acceleration factor of 2 is now readily available, we estimate that even some partial implementation of the parallel imaging can help reduce the total patient table time of our WB MRI exam to less than 45 minutes.…”

Section: Discussionmentioning

confidence: 99%

Fast dixon‐based multisequence and multiplanar MRI for whole‐body detection of cancer metastases

Costelloe

Madewell

et al. 2009

Magnetic Resonance Imaging

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Purpose:To develop and demonstrate the feasibility of multisequence and multiplanar MRI for whole-body cancer detection. Materials and Methods:Two fast Dixon-based sequences and a diffusion-weighted sequence were used on a commercially available 1.5 T scanner for whole-body cancer detection. The study enrolled 19 breast cancer patients with known metastases and in multistations acquired wholebody axial diffusion-weighted, coronal T2-weighted, axial/ sagittal pre-and postcontrast T1-weighted, as well as triphasic abdomen images. Three radiologists subjectively scored Dixon images of each series for overall image quality and fat suppression uniformity on a 4-point scale (1 ϭ poor, 2 ϭ fair, 3 ϭ good, and 4 ϭ excellent). Results:Eighteen of the 19 patients completed the wholebody MRI successfully. The mean acquisition time and overall patient table time were 46 Ϯ 3 and 69 Ϯ 5 minutes, respectively. The average radiologists' scores for overall image quality and fat suppression uniformity were both 3.4 Ϯ 0.5. The image quality was consistent between patients and all completed whole-body examinations were diagnostically adequate. Conclusion:Whole-body MRI offering essentially all the most optimal tumor-imaging sequences in a typical 1-hour time slot can potentially become an appealing "one-stopshop" for whole-body cancer imaging. SEVERAL STUDIES have shown that magnetic resonance imaging (MRI) can be used for whole-body (WB) detection of cancer metastases (1-10). In comparison to other imaging modalities, MRI is potentially more desirable for WB imaging because it does not use ionizing radiation, has excellent soft-tissue contrast, and can provide multisequence and multiplanar imaging capabilities for improved diagnostic accuracy. However, the acquisition speed of most MRI sequences is relatively slow. Consequently, the large spatial coverage required in WB imaging often precludes acquiring images of the entire body with a large number of sequences and in different imaging planes. The scan time constraint may be further exacerbated by the fact that obtaining images with and without fat-suppression (which is sometimes needed) requires two separate acquisitions. In addition, fat suppression by the often-used frequency selective saturation techniques is difficult to perform consistently in the setting of WB MRI because of the field inhomogeneity or susceptibility artifacts that occur over the large field-of-view (FOV).Various techniques advocated and used in previous WB MRI studies include the coronal short-tau inversion recovery (STIR) technique (1,2), echo-planar imaging (EPI) technique (3,4), steady-state free-precession (SSFP) technique (5,6), and fat-suppressed three-dimensional (3D) fast spoiled gradient echo technique in conjunction with contrast agent injection (11). Despite their promising results, most of these WB MRI studies suffer from one or more of the above-mentioned technical limitations and have therefore not fully capitalized on the inherent potentials of MRI that are well established for dedicated imag...

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“…However, in approximately 20% of patients who underwent surgical treatment, PET-CT missed metastases [7]. MRI and PET are reported to have comparable accuracy and efficacy for staging lung cancer patients [13]. Whole-body MRI is better for detecting brain and liver metastases (Figure 9), whereas PET-CT is better for detecting bone and soft-tissue metastases or extrathoracic nodal metastases [7].…”

Section: Mri Assessment Of M-classificationmentioning

confidence: 99%

MRI in lung cancer: a pictorial essay

Hochhegger

Marchiori²,

Sedlaczek³

et al. 2011

BJR

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ABSTRACT. Imaging studies play a critical role in the diagnosis and staging of lung cancer. CT and 18-fluorodeoxyglucose positron emission tomography CT (PET/CT) are widely and routinely used for staging and assessment of treatment response. Many radiologists still use MRI only for the assessment of superior sulcus tumours, and in cases where invasion of the spinal cord canal is suspected. MRI can detect and stage lung cancer, and this method could be an excellent alternative to CT or PET/CT in the investigation of lung malignancies and other diseases. This pictorial essay discusses the use of MRI in the investigation of lung cancer. . The lung remains a challenge for MRI, but this method provides excellent tissue differentiation, and new sequences have increased the temporal resolution [3], expanding the use of MRI beyond its traditional applications. MRI can currently be used for establishing tumour node metastasis (TNM) staging, lung cancer screening and assessing lung nodules for likelihood of being benign or malignant [3]. This pictorial essay discusses the use of MRI in the diagnosis and staging of lung cancer. MRI for detection and characterisation of pulmonary nodulesMultidetector CT (MDCT) is routinely used to confirm and characterise lung lesions [1]. It is a very sensitive method for the detection of pulmonary nodules, and is considered the gold standard for detection of these lesions. The sensitivity of MRI for nodules of 5 to 11 mm is between 85% and 95% [4]. Although MDCT can depict nodules as small as 1 or 2 mm, immediate action is recommended only for lesions larger than 7 or 8 mm, depending on the lung cancer risk stratification. Followup to assess growth pattern is recommended for lesions smaller than 7 mm [5]. Koyama et al [6] reported that non-contrast enhanced pulmonary MRI can effectively detect malignant nodules as thin-section MDCT (Figure 1). The overall detection rate of nodules in each MRI sequence (82.5%) was significantly lower than that of MDCT (97.0%, p,0.05), however detection rates were not significantly different for malignant nodules (p.0.05) (Figure 2). Establishing clinical TNM stageThe overall agreement of clinical TNM (cTNM) staging established by CT compared with post-operative pathological TNM (pTNM) is not significantly better than 50%. Obviously, this comparison does not take into account cases in which the cTNM contraindicates surgery, as it does for the majority of cases. CT and PET-CT are currently the modalities recommended for assessing lung cancer if radical treatment (surgery or other therapeutic modality with curative intent) is suggested [1]. However, the capabilities of MRI have not yet been properly explored. MRI assessment of T-classificationThe T-stage of a tumour is the primary determinant of its resectability [7]. Evaluation of the primary tumour includes an assessment of its size, and the presence and extent of mediastinal or chest wall involvement. Of particular importance is the distinction between T3 and T4 tumours [7]. The definition of a T3 lesion i...

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High-Resolution Whole-Body Magnetic Resonance Image Tumor Staging With the Use of Parallel Imaging Versus Dual-Modality Positron Emission Tomography–Computed Tomography

Abstract: WB-MRI and PET-CT are reliable imaging modalities for tumor staging. WB-MRI is highly sensitive in detecting distant metastases; PET-CT is superior in lymph node staging. PAT makes high-resolution WB-MRI feasible within less than 1 hour.

Cited by 161 publications

References 33 publications

Half‐fourier‐acquisition single‐shot turbo spin‐echo (HASTE) MRI of the lung at 3 Tesla using parallel imaging with 32‐receiver channel technology

Half‐fourier‐acquisition single‐shot turbo spin‐echo (HASTE) MRI of the lung at 3 Tesla using parallel imaging with 32‐receiver channel technology

Fast dixon‐based multisequence and multiplanar MRI for whole‐body detection of cancer metastases

MRI in lung cancer: a pictorial essay

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