High retinoic acid receptor-related orphan receptor A gene expression in peripheral blood leukocytes may be related to acute myocardial infarction

Meng, Heyu; Ruan, Jianjun; Tian, Xiaomin; Li, Lihong; Chen, Weiwei; Meng, F.

doi:10.1177/03000605211019663

Cited by 6 publications

(7 citation statements)

References 38 publications

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“…The RORA gene was reported to be upregulated in patients with AMI (just like the results of qRT-PCR), which might suppress hypoxic injury of cardiomyocyte cells in AMI by inhibiting oxidative stress and apoptosis. 69,70 Meanwhile, the diagnostic significance of FASLG was detected in AMI, 10 which was consistent with our findings, indicating that these biomarker genes were still worthy of study in AMI.…”

Section: Discussionsupporting

confidence: 88%

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics

You,

Dong

2023

JIR

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Previous studies have confirmed that inflammation and immunity are involved in the pathogenesis of acute myocardial infarction (AMI). However, only few related genes are identified as biomarkers for the diagnosis and treatment of AMI. Patients and Methods: GSE48060 and GSE60993 datasets were retrieved from Gene Expression Omnibus. The differentially expressed immuno-inflammation-related genes (DEIIRGs) were obtained from GSE48060, and the biomarkers for AMI were screened and validated using the "Neuralnet" package and GSE60993 dataset. Further, the biomarker-based nomogram was constructed, and miRNAs, transcription factors (TFs), and potential drugs targeting the biomarkers were explored. Furthermore, immune infiltration analysis was analyzed in AMI. Finally, the biomarkers were verified by assessing their mRNA levels using real-time quantitative PCR (RT-qPCR). Results: First, eight biomarkers were screened via bioinformatics, and the artificial neural network model indicated a higher prediction accuracy for AMI even in the validation dataset. Nomogram had accurate forecasting ability for AMI as well. The TFs GTF2I, PHOX2B, RUNX1, and FOS targeting hsa-miR-1297 could regulate the expressions of ADM and CBLB, and RORA could effectively interact with melatonin and citalopram. RT-qPCR results for ADM, PI3, MMP9, NRG1 and CBLB were consistent with those of bioinformatic analysis. Conclusion:In conclusion, eight key immuno-inflammation-related genes, namely, SH2D1B, ADM, PI3, MMP9, NRG1, CBLB, RORA, and FASLG, may serve as the potential biomarkers for AMI, in which the downregulation of CBLB and upregulation of ADM, PI3, and NRG1 in AMI was detected for the first time, providing a new strategy for the diagnosis and treatment of AMI.

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Section: Discussionsupporting

confidence: 88%

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics

You,

Dong

2023

JIR

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“…RORα plays an essential role in the regulation of cardiovascular function including circadian rhythm, development, and metabolism [183][184][185]. One human retrospective study found that RORα mRNA expression levels in patients with acute myocardial infarction is significantly higher than that in patients with stable coronary artery disease [186]. Serum antibody levels of Claudin domain containing 1 (CLDND1)-derived peptides are elevated in patients with cerebral infection, CVDs or diabetes mellitus as compared to healthy controls.…”

Section: Retinoic Acid-related Orphan Receptor (Ror)mentioning

confidence: 99%

Brain nuclear receptors and cardiovascular function

Wang

Yang

2023

Cell Biosci

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Brain–heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence indicates that a number of these brain NRs regulate multiple aspects of cardiovascular diseases (CVDs), including hypertension, heart failure, atherosclerosis, etc. In this review, we will elaborate recent findings that have established the physiological relevance of brain NRs in the context of cardiovascular function. In addition, we will discuss the currently available evidence regarding the distinct neuronal populations that respond to brain NRs in the cardiovascular control. These findings suggest connections between cardiac control and brain dynamics through NR signaling, which may lead to novel tools for the treatment of pathological changes in the CVDs.

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“…With respect to translational approaches, the REVERB agonist SR9009 when given early after ischemia, in mice, improved ischemia-perfusion-related remodeling and cardiac function ( Reitz et al, 2019 ). In addition to REVERB agonists, attention is currently being applied to the development of RORa ligands for cardiovascular disease, for example, they are overexpressed in acute myocardial infarction ( Meng et al, 2021 ).…”

Section: Circadian Disruption In Vascular Diseasementioning

confidence: 99%

The Role of Circadian Clock Genes in Critical Illness: The Potential Role of Translational Clock Gene Therapies for Targeting Inflammation, Mitochondrial Function, and Muscle Mass in Intensive Care

Ray

2022

J Biol Rhythms

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The Earth’s 24-h planetary rotation, with predictable light and heat cycles, has driven profound evolutionary adaptation, with prominent impacts on physiological mechanisms important for surviving critical illness. Pathways of interest include inflammation, mitochondrial function, energy metabolism, hypoxic signaling, apoptosis, and defenses against reactive oxygen species. Regulation of these by the cellular circadian clock (BMAL-1 and its network) has an important influence on pulmonary inflammation; ventilator-associated lung injury; septic shock; brain injury, including vasospasm; and overall mortality in both animals and humans. Whether it is cytokines, the inflammasome, or mitochondrial biogenesis, circadian medicine represents exciting opportunities for translational therapy in intensive care, which is currently lacking. Circadian medicine also represents a link to metabolic determinants of outcome, such as diabetes and cardiovascular disease. More than ever, we are appreciating the problem of circadian desynchrony in intensive care. This review explores the rationale and evidence for the importance of the circadian clock in surviving critical illness.

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High retinoic acid receptor-related orphan receptor A gene expression in peripheral blood leukocytes may be related to acute myocardial infarction

Cited by 6 publications

References 38 publications

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics

Brain nuclear receptors and cardiovascular function

The Role of Circadian Clock Genes in Critical Illness: The Potential Role of Translational Clock Gene Therapies for Targeting Inflammation, Mitochondrial Function, and Muscle Mass in Intensive Care

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