High-Risk Adult Wilms’ Tumour in Pregnancy: A Case Report

Abstract

Wilms' tumour is the most common renal neoplasm in children with an incidence of 10 cases per 1 million children and a median age at diagnosis of 3.5 years. In Western countries its occurrence in adults is 0.2 cases per million people in western countries and carries a poorer prognosis. The co-existence of Adult Wilms' tumour and pregnancy is extremely rare with less than 20 cases published in the English literature. We present a case of a Malawian woman who had progressive high-risk metastatic Adult Wilms' tumour in pregnancy after nephrectomy, radiotherapy and two lines of chemotherapy.

Disseminated adult Wilms tumor in pregnancy: Leveraging multidisciplinary care in a low‐resource setting

“…It is rarely seen in adults, with an incidence of 0.2 cases per million, 1 and predominantly occurs in younger adults with a median diagnosis at age 34 years 5 . Although adult WT is histologically similar to pediatric nephroblastoma, the clinical presentation tends to differ, with adults having a higher stage at diagnosis and poorer overall prognosis 6 . Women tend to have a higher survival rate compared with men 7 …”

“…5 Although adult WT is histologically similar to pediatric nephroblastoma, the clinical presentation tends to differ, with adults having a higher stage at diagnosis and poorer overall prognosis. 6 Women tend to have a higher survival rate compared with men. 7 The coexistence of WT and pregnancy is extremely rare, with only few cases have been reported in the literature.…”