High risk factors related to lymph node metastasis in early gastric cancer: A retrospective observational study

Abstract

Lymph node metastasis (LNM) is a key factor affecting the prognosis of patients with early gastric cancer. This is a retrospective study, conducted between January 20, 2010 and January 30, 2019 and included 402 patients with early-stage gastric cancer who underwent radical gastrectomy at The Affiliated People Hospital of Ningbo University. Clinical and pathological data including patients’ gender, age, tumor location, gross typing, depth of invasion, tumor maximum diameter, type of differentiation, vascular invasion, presence or absence of signet ring cells, and LNM data were collected and analyzed. Univariate analysis identified positive relationships between patient gender, tumor invasion depth, tumor size, presence or absence of vascular involvement, and differentiation type with LNM ( P < .05). Multivariate analysis subsequently confirmed tumor size (odds ratio [OR]: 2.38, 95% confidence interval [CI]:1.15–4.92, P = .02), vascular involvement (OR: 4.35, 95% CI: 2.00–9.47, P < .001), and depth of invasion (OR: 6.63, 95% CI: 2.19–20.06, P = .001) as independent risk factors for LNM ( P < .05). Tumor size, vascular involvement, and depth of invasion are independent risk factors for LNM in cases of early-stage gastric cancer.

Risk Factors for Lymph Node Metastasis in a Western Series of Patients with Distal Early Gastric Cancer

“…Risk factors for LNM are well established in Eastern countries [5,16,17]. Nevertheless, an analysis of predictive factors for LNMs in EGC remains uncommon in the West, where series of patients are smaller in comparison to the East [3,[17][18][19][20]. Moreover, the risk of LNMs in Western patients with EGC is higher, probably due to a higher incidence of T1b cancers [21,22].…”