High‐risk HPV positivity is a long‐term risk factor for recurrence after cervical excision procedure in women living with HIV

Agarossi, Alberto; Carpini, Giovanni Delli; Sopracordevole, Francesco; Serri, Matteo; Giannella, Luca; Gardella, Barbara; Maestri, Marta; Fabro, Anna Del; Sansone, Matilde; Fallani, Maria Grazia; Pieralli, Annalisa; Fasolo, Michela; Mazzali, Cristina; Ciavattini, Andrea

doi:10.1002/ijgo.13674

Cited by 6 publications

(8 citation statements)

References 23 publications

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“…(iv) The present analysis did not consider several features that might influence patient outcomes. In particular, we were not able to correct our results on patient medical history, smoking history, and sexual activity [21][22][23]. All those points might influence the primary outcome measure and should be considered in everyday clinical practice.…”

Section: Discussionmentioning

confidence: 82%

“…All those points might influence the primary outcome measure and should be considered in everyday clinical practice. However, most of these features (indirectly) impacted the risk of HPV persistence, which is one of the variables that we included in our model [21][22][23][24][25]. (v) Our analysis excluded patients undergoing cold-knife conization.…”

Section: Discussionmentioning

confidence: 99%

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Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

et al. 2022

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Background: Cervical dysplasia persistence/recurrence has a great impact on women’s health and quality of life. In this study, we investigated whether a prognostic nomogram may improve risk assessment after primary conization. Methods: This is a retrospective multi-institutional study based on charts of consecutive patients undergoing conization between 1 January 2010 and 31 December 2014. A nomogram assessing the importance of different variables was built. A cohort of patients treated between 1 January 2015 and 30 June 2016 was used to validate the nomogram. Results: A total of 2966 patients undergoing primary conization were analyzed. The median (range) patient age was 40 (18–89) years. At 5-year of follow-up, 6% of patients (175/2966) had developed a persistent/recurrent cervical dysplasia. Median (range) recurrence-free survival was 18 (5–52) months. Diagnosis of CIN3, presence of HR-HPV types, positive endocervical margins, HPV persistence, and the omission of HPV vaccination after conization increased significantly and independently of the risk of developing cervical dysplasia persistence/recurrence. A nomogram weighting the impact of all variables was built with a C-Index of 0.809. A dataset of 549 patients was used to validate the nomogram, with a C-index of 0.809. Conclusions: The present nomogram represents a useful tool for counseling women about their risk of persistence/recurrence after primary conization. HPV vaccination after conization is associated with a reduced risk of CIN2+.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

et al. 2022

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“…Terlebih pada perempuan dengan HIV yang berusia lebih dari 40 tahun yang diperkirakan empat kali lebih berisiko untuk mengalami kekambuham. Secara keseluruhan kekambuhan pada perempuan dengan HIV mencapai 21,4% (Agarossi et al, 2021;Pambinkavil et al, 2023).…”

Section: Diskusiunclassified

Faktor Risiko Kekambuhan Lesi Prakanker Serviks Pasca Pengobatan Tinjauan Literatur

Fujiasti,

Helda

2024

jsi

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Kanker serviks merupakan jenis kanker yang terjadi pada seviks yaitu saluran masuk menuju uterus dari vagina, World Health Organization (WHO) menyusun strategi untuk mengeliminasi penyakit ini melalui upaya pencegahan primer, sekunder dan tersier dengan target yang ingin dicapai yaitu 90 – 70 – 90 pada tahun 2030. Tujuan penelitian ini untuk memberikan gambaran umum serta mengetahui faktor-faktor yang berhubungan dengan kekambuhan lesi prakanker serviks pasca pengobatan pada perempuan. Metode tinjauan Literatur ini menggunakan metode PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses). Sumber rujukan merupakan artikel tahun 2019 – 2024 yang ditelusuri melalui database Science Direct, ProQuest dan Scopus dengan kata kunci risk factors, recurrence, precancer lesion, cervical cancer. Berdasarkan kata kunci, terdapat 357 artikel yang teridentifikasi dan hanya 17 artikel yang ditelaah sebagai rujukan. Hasil: Dari 17 artikel yang ditelaah diketahui bahwa recurrence rate dari lesi prakanker serviks pasca pengobatan berkisar antara 6,1% hingga 21,69%. Perempuan dengan infeksi HPV tipe high risk (hr-HPV) genotype 16,18,33 dan 52 pasca pengobatan, usia >35 tahun, hasil margin positif pada pemeriksaan sel yang diambil saat pengobatan, status HIV positif, riwayat persalinan kurang bulan, adanya komorbid, paritas <4 dan perilaku merokok berisiko lebih dari dua kali terhadap kekambuhan lesi prakanker serviks. Kesimpulan dari penelitian ini menunjukan tingginya recurrence rate dari lesi prakanker serviks menunjukkan bahwa perlunya kepatuhan dalam melakukan pemeriksaan berkala pasca pengobatan. Selain itu menghindari perilaku seks berisiko merupakan salah satu upaya pencegahn terhadap faktor risiko kekambuhan.

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“…HPV variants are further classified into high-risk and low-risk categories, primarily determined by their association with the development of cancer [48]. High-risk HPVs, such as HPV16, HPV18, HPV31, and others, display a notable preference for mucosal tissues and are strongly correlated with various cancers, including cervical, anal, and oropharyngeal cancers [49]. These high-risk variants carry specific viral oncoproteins like E6 and E7, which disrupt the regulatory mechanisms of host cells, fostering uncontrolled cell growth and potentially progressing towards malignancy [50].…”

Section: Virology and Classificationmentioning

confidence: 99%

Unravelling the Impact of Human Papillomavirus (HPV): A Comprehensive Exploration of its Role in Cancer Progression and Global Health Challenges

Potale,

K Kasat,

Kumar

et al. 2024

BIO Web Conf.

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HPV represents a large group of double stranded DNA viruses that are highly involved with different types of human cancers. This synopsis describes the complexities surrounding HPV virology, classifications, and genomic variation, especially focusing on high-risk strains such as HPV16 and HPV18, the main causative factors for cervical cancers. The International Committee on Taxonomy of Viruses specifies more than 200 HPV types each associated with a respective disease and indicated in Table 1. HPV spread is mostly due to direct skin-to-skin contact between individuals’ sex organs causing infections on the mucous membrane and keratinized epithelial cells. Although majority of the infections are asymptomatic, some chronic HRHPV infections may progress into cancers because of oncoproteins E6 and E7. The high-risk variants of HPV lead to cervical, anal, and oropharyngeal cancers whereas the low-risk types cause harmless genital warts. While integrating HPV DNA into the host genome, orchestrated by oncoproteins E6 and E7 disrupts the cell regulatory mechanism; this leads to abnormal control over cell multiplication–one of the major elements of the process that develops to HPV induced cancer. A classic case is cervical cancer that has been extensively investigated as one of the highly documented HPV associated malignancies. Pap smears and HPV DNA tests are among the screening means that lower the incidents and deaths associated with cervical cancers. HPV-associated cancers of the head and neck, anus, penis, vulva, and vagina all show a characteristic profile in terms of the pathogen aetiology and risks involved. HPV-related head and neck cancers affect non-smokers and show good response to standard therapies. HPV poses increased anal cancer risk for immunocompromised individuals highlighting the complexity of interdependence of immunity and cancer development. Penile cancer results from poor hygiene and non-circumcision. Vulvar and virginal cancer mostly affects women, and the risk factors involve HPV infection and smoking. Therefore, various types of multidisciplinary approach that may include surgeries, radiotherapy, and chemotherapy are necessary to ensure proper treatment. Certain cancers are strongly associated with some high-risk HPV genotypes, such as HPV-16 and HPV-18; thus, vaccination is important. HPV infection outcomes are determined by the immune response as well as clearance of HPV infection. Screening and immunological understanding for early detection of HPV related health risks is fundamental. However, this encompassing review highlights the multi-dimensional impact of HPV encompassing virology of HPV, cancer specific presentation of HPV and control including prevention of HPV infection, screening, and research on cancer attributable by HPV and strategies towards mitigation of this global health problem.

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High‐risk HPV positivity is a long‐term risk factor for recurrence after cervical excision procedure in women living with HIV

Cited by 6 publications

References 23 publications

Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Faktor Risiko Kekambuhan Lesi Prakanker Serviks Pasca Pengobatan Tinjauan Literatur

Unravelling the Impact of Human Papillomavirus (HPV): A Comprehensive Exploration of its Role in Cancer Progression and Global Health Challenges

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