High‐risk human papillomavirus genotypes among healthy males from one hospital in Beijing, China

Abstract

Human papillomavirus (HPV) infection causes a huge disease burden for both men and women with highly contagious through sexual contact. 1 Persistent high-risk HPV (HR-HPV) infection is known to lead to the development of cervical cancer, as well as the formation of tumors in the oropharyngeal, vagina, vulva, penis, anus, and head and neck, with a rapidly increasing incidence among young men. 2Previous studies have indicated that the global pooled prevalence of HPV in general men was 31% for any HPV and 21% for HR-HPV. 3 However, there is limited data available on healthy males in China. In this study, we aimed to describe the detection rate of HR-HPV among healthy males from a hospital in Beijing, China.The cross-sectional study was conducted from March 2013 to February 2023 at Beijing Chaoyang Hospital affiliated to Capital Medical University in China. A total of 357 healthy males who accepted for HR-HPV detection through physical examination were included in this study. The detailed experimental operation protocol was described in Supporting Information S1: File S1. The basic information and detection results were analyzed.Among 357 healthy males, 86 were infected with HR-HPV resulting in with a detection rate of 24.09% (95% confidence interval[CI]: 19.74%−28.87%) (Figure 1). The top five HR-HPV types with the highest detection rates were HPV-16 (5.60%), HPV-52 (4.76%), HPV-51 (4.48%), HPV-58 (3.36%), and HPV-66 (3.25%) (Figure 1A).