High‐risk human papillomavirus in patients with oral leukoplakia and oral squamous cell carcinoma—A multi‐centre study in Sweden, Brazil and Romania

Sundberg, Jonas; Öhman, Jenny; Korytowska, Magdalena; Wallström, Mats; Kjeller, Göran; Andersson, Maria; Horal, Peter; Lindh, Magnus; Giglio, Daniel; Kovács, Anikó; Sand, Lars; Hirsch, Jan‐Michaél; Ferracini, Lais Magda Araújo; Souza, Ana Carolina Mamana Fernandes de; Părlătescu, Ioanina; Dobre, Maria; Hinescu, Mihail Eugen; Braz‐Silva, Paulo Henrique; Țovaru, Șerban; Hasséus, Bengt

doi:10.1111/odi.13510

Cited by 13 publications

(19 citation statements)

References 33 publications

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“…It is likely prudent, however, to advise patients with OLK to refrain from using high alcohol‐containing mouthwashes (McCullough & Farah, 2008), given results of a large retrospective investigation which showed potential risks for head and neck cancer subsites and in long‐term and frequent users of mouthwash (Boffetta et al., 2016). HPV has not been found to be a substantial contributor to induction of OLK, with some studies failing to detect it in a wide variety of populations over a long timeframe (Sundberg et al, 2019; Sundberg et al, 2020), while others have shown only very low positive rates of detection (<5%) with no difference to normal or OSCC samples (Della Vella et al, 2020; Yang et al, 2019). Pooled estimates of HPV prevalence in OLK (20.2%) and PVL (24.7%) were no different to other potentially malignant conditions, such as oral lichen planus (23.0%) and oral submucous fibrosis (28.6%), and were independent of OED (de la Cour, Sperling, Belmonte, Syrjänen, & Kjaer, 2020).…”

Section: Clinical and Histopathological Determinants Of Malignant Tramentioning

confidence: 99%

“…HPV has not been found to be a driver of oncogenesis or a contributor to MT of OLK, although overexpression of p16INK4A in dysplastic epithelium has been noted (Wu et al, 2019), but found not to be HPV‐dependent (Tomo et al, 2020). Furthermore, p16 is not a reliable biomarker for HPV infection in patients with OLK or OSCC (Sundberg et al, 2019; Sundberg et al, 2020).…”

Section: Clinical and Histopathological Determinants Of Malignant Tramentioning

confidence: 99%

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Molecular, genomic and mutational landscape of oral leukoplakia

Farah

2020

Oral Diseases

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Oral leukoplakia (OLK) and its more aggressive clinical variant proliferative verrucous leukoplakia (PVL) remain enigmatic disorders clinically and histopathologically. Despite decades of research into both, there has been only incremental advancement in our understanding of their aetiology and pathogenesis and only minimal improvement in effective management strategies. Currently, no specific prognostic genetic or molecular marker has been reported for leukoplakia. There is, however, an emerging body of evidence characterising the genomic and transcriptomic profile of OLK. Regardless of the significance of cellular and architectural features of OLK and PVL, it is clear from studies reported in this review that new emerging evidence points to the presence of premalignant molecular subtypes of leukoplakia which require further investigation. This up‐to‐date review explores the contemporary genomic, transcriptomic and mutational landscape of leukoplakia broadly, discusses concepts that may not be widely recognised or accepted and purposefully highlights studies with juxtaposed findings in an effort to challenge dogma. It also highlights the urgent need for a concerted international effort of original collaborative research which will only occur by pooling collective efforts, resources and intellect to define the molecular fingerprint of this enigmatic disorder, in the hope it will better inform diagnosis, stratification and treatment.

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Section: Clinical and Histopathological Determinants Of Malignant Tramentioning

confidence: 99%

Section: Clinical and Histopathological Determinants Of Malignant Tramentioning

confidence: 99%

Molecular, genomic and mutational landscape of oral leukoplakia

Farah

2020

Oral Diseases

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“…Among these 26 manuscripts, 13 were excluded due to not pertinent full text (11 studies with no OLK subdivision in a study group or no subdivided outcomes, even the number of OLK cases was known, 2 studies with no OLK). There were 6 articles with casecontrol studies [5][6][7][8][9][10], 7 articles with cross-sectional studies [11][12][13][14][15][16][17] and no articles with cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…Subsequently, outcomes were analysed to estimate overall prevalence in the group without and with dysplasia. Dysplasia of leukoplakia was mentioned in 7 articles [5,7,9,11,14,16,17]. Four articles were excluded due to lack of HPV detected in some study or not-subdivid- There were limitations of some analysed studies associated with HPV-DNA detection: high risk of false outcomes due to non-quantitative PCR and PCR-product visualization on gel [5,7,8,13,14], and a very small group of OLK [6,10,13].…”

Section: Resultsmentioning

confidence: 99%

Human papillomavirus and leukoplakia of the oral cavity: a systematic review

Radzki¹,

Kusiak²,

Ordyniec-Kwaśnica³

et al. 2022

pdia

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Introduction: Human papillomavirus (HPV) infection is mainly a problem of the female reproductive tract. It can occur in the oral cavity as well. Commonly HPV infections are subclinical, without any visible symptoms, and last no longer than 2 years. Usually the clinical manifestation of HPV infection is benign, but in some cases it can also promote malignant transformation. In the paper we have tried to estimate the prevalence of HPV detected in samples of oral leukoplakia (OLK), the most common premalignant lesions of the oral mucosa. Aim: To review the current literature to estimate the prevalence of HPV (HPV DNA) detected in samples of oral leukoplakia. Material and methods: We searched PubMed/Medline, Scopus, and Cochrane Library databases for studies that examined the prevalence of HPV in leukoplakia with HPV DNA detection by polymerase chain reaction. Results: HPV positive cases in OLK ranged from 0% to 100% in studies. The overall HPV prevalence in leukoplakia was 6.66%. The prevalence of HPV 16 positive cases was 2.95%. The high-risk HPV prevalence was 5.16%, when the low-risk HPV prevalence was 3.32%. When dysplasia is mentioned, HPV was detected in 25.93% of lesions with dysplasia, compared to 37.14% among non-dysplastic lesions. Conclusions: Further studies should be extended also to include low-risk HPV and compare its prevalence with presence of dysplasia in leukoplakia. Besides, leukoplakia and other premalignant lesions can no longer be treated as one lesion.

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“…Several studies have implicated tobacco use in the aetiology of OL. In addition, excessive consumption of alcohol and infection with human high-risk papillomavirus have been proposed to play roles in the development of OL [3,6], with the latter showing different infection prevalence rates [7].…”

Section: Introductionmentioning

confidence: 99%

Patient-reported pain after surgical removal of leukoplakia – an observational 1-year follow-up study

Korytowska

Schwab²,

Giglio

et al. 2021

Acta Odontologica Scandinavica

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Objective: Oral leukoplakia (OL) presents as a white lesion of the oral mucosa and is not typically associated with the sensation of pain. OL should be surgically removed when possible because it is considered a potentially malignant oral disorder (PMOD). This study assessed the pain sensations experienced by patients in association with the occurrence and surgical treatment of OL. Methods: Inclusion criteria were: a clinical diagnosis of OL; biopsy excision; and observation for at least 12 months in the ORA-LEU-CAN study. At the first visit, all the patients were asked about the occurrence of symptoms within the lesion. Ninety-four subjects were assessed over a period of 1 year. All patients underwent complete removal of OL. The patient cohort was divided into three sub-groups: (i) no pain before excision and at the 1-year follow-up; (ii) pain before excision; and (iii) pain at the 1year follow-up. Results: Overall, pain was reported by 21.3% of the patients at the study start whereas 13.8% of the patients reported pain 1 year after surgical treatment. Patient-reported pain from the lesion at study inclusion was significantly associated with lesions found on the lateral side of the tongue (p=.002). Pain reported by patients one year after surgery was significantly related to female gender (p=.038) and the presence of epithelial cell dysplasia (p=.022). Conclusion:We conclude that surgical removal of OL results in a low risk of long-term post-surgical pain. However, OL located on the lateral side of the tongue and in OL with dysplasia are more likely to be associated with pain.

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High‐risk human papillomavirus in patients with oral leukoplakia and oral squamous cell carcinoma—A multi‐centre study in Sweden, Brazil and Romania

Cited by 13 publications

References 33 publications

Molecular, genomic and mutational landscape of oral leukoplakia

Molecular, genomic and mutational landscape of oral leukoplakia

Human papillomavirus and leukoplakia of the oral cavity: a systematic review

Patient-reported pain after surgical removal of leukoplakia – an observational 1-year follow-up study

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