High‐risk human papillomavirus infection in the prediction of poor treatment response and disease recurrence in patients with vulvovaginal condyloma

Abstract

A high HR-HPV load is a risk factor for recurrence, but is not related to treatment response. A poor treatment response is more related to abnormal cytology than it is to viral load.

Prevalence of Cervico-vaginal High-risk HPV Types and Other Sexually Transmitted Pathogens in Anogenital Warts Patients

“…Nonetheless, scant data exist when testing for HR-HPV types restricted to cervico-vaginal smears of patients with AGWs. A study from South Korea on 18 patients reported that 50% of cervical scrapings were infected with HR-HPV types (18), while a slightly higher rate was found by researchers in Ireland (16). Although, our rate of 34.2% is considerably lower compared to the aforementioned studies, it is strikingly similar to what was reported (33%) in an older study from Greece which included 100 patients with AGWs (17).…”

“…It is noteworthy that patients with recurrent AGWs were diagnosed with cervico-vaginal HR-HPV types more commonly, as opposed to those with a single episode of AGWs. Recurrent AGWs have already been associated with high HR-HPV DNA load both in cervical scrapings (18) and in AGWs tissue samples (9) in smaller studies. In line with these, our finding may indicate that HR-HPV types could trigger AGWs recurrences more often.…”

“…As far as the other sexually transmitted pathogens (STPs), namely Chlamydia trachomatis, Mycoplasma genitalium, Ureaplasma parvum/Ureaplasma urealyticum (Ureaplasma spp), and Mycoplasma hominis, are concerned, women with cervical HPV infection seem to exhibit higher rates of their presence, compared to those without HPV infection (18)(19)(20)(21)(22). Of note, this link may promote the HPV-driven cervical carcinogenesis (22).…”