2012
DOI: 10.1002/ijc.27499
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High risk of non‐sentinel node metastases in a group of breast cancer patients with micrometastases in the sentinel node

Abstract: Axillary lymph node dissection (ALND) in breast cancer patients with positive sentinel nodes is under debate. We aimed to establish two models to predict non-sentinel node (NSN) metastases in patients with micrometastases or isolated tumor cells (ITC) in sentinel nodes, to guide the decision for ALND. A total of 1,577 breast cancer patients with micrometastases and 304 with ITC in sentinel nodes, treated by sentinel lymph node dissection and ALND in [2002][2003][2004][2005][2006][2007][2008] were identified in… Show more

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Cited by 24 publications
(15 citation statements)
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“…In a multivariate analysis of the remaining 181 patients, including tumor size and proportion of positive sentinel nodes, no significant difference was found in the risk of nonsentinel node metastases between patients with symptomatic and screen-detected cancers (OR 0.45; 95% CI 0.16-1.27, p ¼ 0.13) (Table II). Tumor size and proportion of positive sentinel nodes were not significantly associated with nonsentinel node metastases in the multivariate analysis, but again with estimates in accordance with previous results [11].…”
Section: Resultssupporting
confidence: 91%
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“…In a multivariate analysis of the remaining 181 patients, including tumor size and proportion of positive sentinel nodes, no significant difference was found in the risk of nonsentinel node metastases between patients with symptomatic and screen-detected cancers (OR 0.45; 95% CI 0.16-1.27, p ¼ 0.13) (Table II). Tumor size and proportion of positive sentinel nodes were not significantly associated with nonsentinel node metastases in the multivariate analysis, but again with estimates in accordance with previous results [11].…”
Section: Resultssupporting
confidence: 91%
“…When adjusting for tumor size, proportion of positive sentinel nodes, lymphovascular invasion, hormone receptor status and location of tumor in the breast, symptomatic cancers were still not associated with a higher risk of non-sentinel node metastases compared to screen-detected cancers (OR 1.12, CI 0.77-1.62, p ¼ 0.55). In the multivariate analysis, tumor size, proportion of positive sentinel nodes and lymphovascular invasion were associated with an increased risk of non-sentinel node metastases, while hormone receptor status and location of tumor in the breast were not significantly associated, although with estimates in the range found in the previous study on risk factors for non-sentinel node metastases [11].…”
Section: Resultsmentioning
confidence: 48%
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“…In contrast, the largest retrospective series of micrometastatic SLN patients suggest that there is a small minority of patients with SLN micrometastasis who have a significant risk and incidence of non-SLN (NSLN) involvement [35]. Nomograms devised for the prediction of NSLN metastasis in patients with micrometastatic SLNs suggest over 30% or close to 50% risk at their extremes [36][37][38].…”
Section: List Of Tablesmentioning
confidence: 99%
“…Nomograms devised for the prediction of NSLN metastasis in patients with micrometastatic SLNs suggest over 30% or close to 50% risk at their extremes [36][37][38]. On the basis of multivariate models, several factors affect the risk of NSLN involvement beside the size of the SLN metastasis [35][36][37][38][39]. Therefore, the omission of ALND in all micrometastatic SLN patients might be negligent.…”
Section: List Of Tablesmentioning
confidence: 99%