High risk of severe endocarditis in patients on chronic dialysis

Hanslik, Thomas; Flahault, Antoine; Vaillant, Jean-Nicolas; Boulard, Jean-Claude; Moulonguet-Doleris, L.; Prinseau, J; Baglin, A

doi:10.1093/ndt/12.6.1301

Cited by 19 publications

(16 citation statements)

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“…A population-based study in the general population by Berlin et al [18]found an incidence rate of endocarditis of 11.6/100,000/year, 4.45/100,000/year for community-acquired native valve endocarditis, and 0.94/100,000/year for nosocomial endocarditis. Previous estimates of the incidence of endocarditis in dialysis patients had ranged from 50–130 cases/ 100,000 person-years [1], indicating they have a higher risk than the general population, although these were not truly population-based. Age is a known risk factor for endocarditis [5].…”

Section: Discussionmentioning

confidence: 99%

“…Endocarditis would be a rare but devastating contributor to this excess mortality. The literature has focused on catheters as sources for recurrent bacteremia and endocarditis in dialysis patients [23, 24, 25, 26]. Unfortunately, the USRDS has limited data available on access type.…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial endocarditis has been described as a serious cause of morbidity and mortality in dialysis patients [1, 2, 3, 4], but its incidence and risk factors have never been defined in a nationally representative population. It is unclear whether endocarditis is more common or causes greater morbidity and mortality in dialysis patients than in the general population.…”

Section: Introductionmentioning

confidence: 99%

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Hospitalizations for Bacterial Endocarditis after Initiation of Chronic Dialysis in the United States

Abbott

Agodoa

2002

Nephron

108

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Aims: Bacterial endocarditis is a significant cause of morbidity and mortality but has not been studied in a national population of end-stage renal disease patients. Methods: 327,993 dialysis patients in the United States Renal Data System initiated from 1 January 1992 to 30 June 1997 were analyzed in a historical cohort study of hospitalized bacterial endocarditis (ENDO, ICD9 Code 421.x). Renal transplant recipients were excluded. Results: Hemodialysis patients had an age-adjusted incidence ratio for ENDO of 17.86 (95% confidence interval, 6.62–48.90) and peritoneal dialysis patients 10.54 (95% CI, 0.71– 158.13, not statistically significant) compared to the general population in 1996 (the National Hospital Discharge Survey). 6.1% of patients with ENDO underwent valve replacement surgery. In multivariate analysis, hemodialysis (vs. peritoneal dialysis), earlier year of dialysis, cardiac disease, and lower serum creatinine and albumin were associated with increased risk of ENDO. In Cox regression analysis, patients with ENDO had increased mortality, relative risk 1.48 (95% CI 1.45–1.73). Conclusions: Patients on chronic dialysis were at increased risk for ENDO compared to the general population. The risk for peritoneal dialysis patients was not statistically significant, possibly due to the smaller numbers of patients on this modality. Hemodialysis (vs. peritoneal dialysis) and comorbidities were the strongest risk factors for ENDO identified.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hospitalizations for Bacterial Endocarditis after Initiation of Chronic Dialysis in the United States

Abbott

Agodoa

2002

Nephron

108

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“…He also reported that valve calcification repre sents an additive risk factor for endocarditis -similar to our case. 11,12) In this case the patient started deteriorating and retaining fluid because of manifested rightsided heart failure. Blood cultures were negative and signs of infection were attributed to her atypical pneumonia.…”

Section: Discussionmentioning

confidence: 92%

Massive Calcified Tricuspid Valve Endocarditis in a Patient with Dual Lumen Tunneled Venous Catheter

Farag

Weymann

Schmack

et al. 2014

ATCS

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“…Dialysepatienten weisen auch ein erhöhtes Risiko für eine bakterielle Endokarditis als Morbiditäts-und Mortalitätsursache auf [23]. In einer Studie an einer historischen Kohorte, die das Vorkommen einer bakteriellen Endokarditis auf Basis des US Renal Data Systems untersuchte, fand sich eine für das Alter korrigierte Inzidenzrate für die bakterielle Endokarditis im Vergleich zur Allgemeinbevölkerung von 17,9 bei HD-und 10,5 bei PD-Patienten [24].…”

Section: Septikämie Und Endokarditisunclassified

Klinische Ergebnisse an der Peritonealdialyse im Vergleich zur Hämodialyse

Roob

2005

Wien Klin Wochenschr

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In addition to kidney transplantation, peritoneal dialysis (PD) and hemodialysis represent two options for renal replacement therapy in patients with end-stage renal disease (ESRD). Given that most patients are suitable for both types of dialysis and that many of them require lifelong therapy, differences in clinical outcome between these treatments are of major interest. Differences between the two dialysis treatments have been described in single clinical aspects (e.g., hyperkalemia, volume status, blood pressure control, cardiac complications), the relevance of which are reflected by mortality rates. Data available so far indicate that overall outcome of patients with ESRD is comparable in the two types of dialysis. However, there are significant differences in subgroups of patients, such as those with diabetes or coronary heart disease. In order to achieve the best possible survival and quality of life in ESRD, the optimal sequence of dialysis treatments during the course of renal replacement therapy, rather than a single type of treatment, has to be considered. The "integrated care concept" takes into account this sequence of dialysis treatments, suggesting that patients should start on PD but be transferred to hemodialysis as soon as PD is no longer adequate. This concept allows longer preservation of residual renal function, better early survival on dialysis and better short-term results of graft survival after kidney transplantation. Thus, if medically suitable, PD should be the first treatment option in patients with ESRD who need renal replacement therapy.

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High risk of severe endocarditis in patients on chronic dialysis

Cited by 19 publications

References 0 publications

Hospitalizations for Bacterial Endocarditis after Initiation of Chronic Dialysis in the United States

Hospitalizations for Bacterial Endocarditis after Initiation of Chronic Dialysis in the United States

Massive Calcified Tricuspid Valve Endocarditis in a Patient with Dual Lumen Tunneled Venous Catheter

Klinische Ergebnisse an der Peritonealdialyse im Vergleich zur Hämodialyse

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