High Risk of Suicide in Behavioral Variant Frontotemporal Dementia

Zucca, Milena; Rubino, Elisa; Vacca, Alessandro; Govone, Flora; Gai, Annalisa; Martino, Paola; Boschi, Silvia; Gentile, Salvatore; Giordana, Maria Teresa; Rainero, Innocenzo

doi:10.1177/1533317518817609

Cited by 24 publications

(21 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In these two cases, possible AD diagnosis was attributed to both patients as their neuropsychiatric symptoms were well-correlated with progressive neurodegeneration in the brain. The presence of SB in these two cases was also consistent with the increased risk of suicidality in patients with AD [45][46][47][48][49]. However, unlike AD, in both cases the cognitive and psychiatric aggravation was rapid (within 2-3 years) and consistent with previously documented progression of these symptoms in CTE [50].…”

Section: Discussionsupporting

confidence: 85%

Severe Suicidality in Athletes with Chronic Traumatic Encephalopathy: A Case Series and Overview on Putative Ethiopathogenetic Mechanisms

Costanza

Radomska

Zenga

et al. 2021

IJERPH

View full text Add to dashboard Cite

Chronic traumatic encephalopathy (CTE) results from repetitive brain injuries and is a common neurotraumatic sequela in contact sports. CTE is often accompanied by neuropsychiatric symptoms, which could escalate to suicidal ideation (SI) and suicidal behaviour (SB). Nevertheless, fairly limited emphasis about the association between suicidality and CTE exists in medical literature. Here, we report two cases of retired professional athletes in high contact sports (boxing and ice hockey) who have developed similar clinical trajectories characterized by progressive neuropsychiatric symptoms compatible with a CTE diagnosis and subsequent SB in its severe forms (medical serious suicide attempt (SA) and completed suicide). In addition to the description of outlining clinical, neuropsychological, neuroimaging, and differential diagnosis elements related to these cases, we also hypothesized some mechanisms that might augment the suicide risk in CTE. They include those related to neurobiological (neuroanatomic/neuroinflammatory) dysfunctions as well as those pertaining to psychiatry and psychosocial maladaptation to neurotraumas and retirement from professional competitive activity. Findings described here can provide clinical pictures to improve the identification of patients with CTE and also potential mechanistic insights to refine the knowledge of eventual severe SB development, which might enable its earlier prevention.

show abstract

Section: Discussionsupporting

confidence: 85%

Severe Suicidality in Athletes with Chronic Traumatic Encephalopathy: A Case Series and Overview on Putative Ethiopathogenetic Mechanisms

Costanza

Radomska

Zenga

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…To our knowledge, this is the first US cohort study to compare suicide risk by dementia subtype. FTD has been associated with higher risk of non‐fatal suicidal acts, but samples were small and did not examine suicide deaths 31–33 . Data were scarce on suicide risk in DLB, which we found to have the second highest rate of suicide (32.57 per 100,000 person‐years).…”

Section: Discussionmentioning

confidence: 82%

Suicide risk in first year after dementia diagnosis in older adults

Schmutte

Olfson

Maust

et al. 2021

Alzheimer's & Dementia

View full text Add to dashboard Cite

Introduction Receiving a diagnosis of Alzheimer's disease or related dementias (ADRD) can be a pivotal and stressful period. We examined the risk of suicide in the first year after ADRD diagnosis relative to the general geriatric population. Methods We identified a national cohort of Medicare fee‐for‐service beneficiaries aged ≥ 65 years with newly diagnosed ADRD (n = 2,667,987) linked to the National Death Index. Results The suicide rate for the ADRD cohort was 26.42 per 100,000 person‐years. The overall standardized mortality ratio (SMR) for suicide was 1.53 (95% confidence interval [CI] = 1.42, 1.65) with the highest risk among adults aged 65 to 74 years (SMR = 3.40, 95% CI = 2.94, 3.86) and the first 90 days after ADRD diagnosis. Rural residence and recent mental health, substance use, or chronic pain conditions were associated with increased suicide risk. Discussion Results highlight the importance of suicide risk screening and support at the time of newly diagnosed dementia, particularly for patients aged < 75 years.

show abstract

“…Patients with bvFTD were found to have significantly higher functional and cognitive impairment levels and were more apathetic and impulsive. However, no differences in neuropsychological characteristics were identified when comparing patients with bvFTD at risk for suicide and patients with bvFTD with no suicide risk (29).…”

Section: Dementiamentioning

confidence: 91%

Mental Disorders, Cognitive Impairment and the Risk of Suicide in Older Adults

2021

View full text Add to dashboard Cite

More than 600 million people are aged 60 years and over are living in the world. The World Health Organization estimates that this number will double by 2025 to 2 billion older people. Suicide among people over the age of 60 is one of the most acute problems. The factors strongly associated with suicide are mentioned: physical illnesses, such as cancer, neurologic disorder, pain, liver disease, genital disorders, or rheumatoid disorders. Moreover, neurologic conditions, especially stroke, may affect decision-making processes, cognitive capacity, and language deficit. In addition to dementia, the most common mental disorders are mood and anxiety disorders. A common symptom of these disorders in the elderly is cognitive impairment. This study aimed to present the relationship between cognitive impairment due to dementia, mood disorders and anxiety, and an increased risk of suicide among older people. Dementia is a disease where the risk of suicide is significant. Many studies demonstrated that older adults with dementia had an increased risk of suicide death than those without dementia. Similar conclusions apply to prodromal dementia Depression is also a disease with a high risk of suicide. Many researchers found that a higher level of depression was associated with suicide attempts and suicide ideation. Bipolar disorder is the second entity in mood disorders with an increased risk of suicide among the elderly. Apart from suicidal thoughts, bipolar disorder is characterized by high mortality. In the group of anxiety disorders, the most significant risk of suicide occurs when depression is present. In turn, suicide thoughts are more common in social phobia than in other anxiety disorders. Suicide among the elderly is a serious public health problem. There is a positive correlation between mental disorders such as dementia, depression, bipolar disorder, or anxiety and the prevalence of suicide in the elderly. Therefore, the elderly should be comprehensively provided with psychiatric and psychological support.

show abstract

High Risk of Suicide in Behavioral Variant Frontotemporal Dementia

Cited by 24 publications

References 54 publications

Severe Suicidality in Athletes with Chronic Traumatic Encephalopathy: A Case Series and Overview on Putative Ethiopathogenetic Mechanisms

Severe Suicidality in Athletes with Chronic Traumatic Encephalopathy: A Case Series and Overview on Putative Ethiopathogenetic Mechanisms

Suicide risk in first year after dementia diagnosis in older adults

Mental Disorders, Cognitive Impairment and the Risk of Suicide in Older Adults

Contact Info

Product

Resources

About