High-salt diet accelerates bone loss accompanied by activation of ion channels related to kidney and bone tissue in ovariectomized rats

Molecular docking and in vivo protective effects of okra (Abelmoschus esculentus) against metabolic dysfunction in high-fat, high-sodium diet-fed rats

“…Low bone mass can result from increased salt intake, which affects bone metabolism. 85 Femur calcium of the group fed HF/NaCl was significantly less than that of normal rats. Okra flesh-treated rats showed a significant reduction in urinary calcium, sodium and potassium and a significant elevation in femur calcium values when compared to rats fed the HF/NaCl diet, whereas okra mucilage exhibited significantly lower urinary calcium (0.61 ± 0.02 mg dl −1 ), sodium (35.34 ± 0.56 mEq per l) and potassium (3.01 ± 0.09 mEq per l) and significantly higher femur calcium (253.83 ± 2.75 mg g −1 ) values.…”

“…11), rats fed HF/NaCl diet had urinary calcium, sodium, and potassium levels that were noticeably higher than those of normal rats. Cui et al 85 also found that high-salt diet resulted in the elevation of urinary sodium and calcium excretion. The Western diet shows a lack of calcium and other trace minerals 86 and may cause calcium deficiency.…”

Microneedle-Coupled Epidermal Sensors for In-Situ-Multiplexed Ion Detection in Interstitial Fluids

“…This is because hypernatremia causes hypertension 43 and excretion of excess sodium ions through the kidney, which in turn causes the loss of Ca 2+ ions. 44 Previous studies in humans have shown that every 0.6 mM increase in ISF K + reduces pH by ∼0.1 unit. 45 This explains our observation that a decrease in pH accompanies the elevation of K + .…”

“…Conversely, the Ca 2+ level in ISF was reduced by HSD and completely recovered by subsequent LSD. This is because hypernatremia causes hypertension and excretion of excess sodium ions through the kidney, which in turn causes the loss of Ca 2+ ions . Previous studies in humans have shown that every 0.6 mM increase in ISF K + reduces pH by ∼0.1 unit .…”

A review of the world's salt reduction policies and strategies – preparing for the upcoming year 2025

“…44 Cui et al found that a high-salt diet in ovariectomy rats could lead to bone microstructure destruction, promote urinary calcium and phosphorus excretion, and accelerate bone turnover, and then result in the loss of bone mass. 45 Therefore, high salt intake increases the risk of osteoporosis (low bone mass) with aging. It is worth noting that an excess of calcium in the urine can also increase the risk of kidney stones.…”