High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals

Itoh, Kazuyoshi; Moriguchi, Ririko; Yamada, Yoshio; Fujita, Misuzu; Yamato, Takako; Oumi, Masayo; Holst, Jens J.; Seino, Yutaka

doi:10.1016/j.nutres.2014.07.013

Cited by 22 publications

(17 citation statements)

References 21 publications

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“…Lipid ingestion causes predominantly a GIP release and subsequently increased insulin secretion in rodents [20 & ] and in humans [21]. Lipid ingestion causes predominantly a GIP release and subsequently increased insulin secretion in rodents [20 & ] and in humans [21].…”

Section: Lipid Sensingmentioning

confidence: 99%

Intestinal nutrient sensing and blood glucose control

Zietek

Daniel

2015

Current Opinion in Clinical Nutrition and Metabolic Care

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Section: Lipid Sensingmentioning

confidence: 99%

Intestinal nutrient sensing and blood glucose control

Zietek

Daniel

2015

Current Opinion in Clinical Nutrition and Metabolic Care

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“…A previous study in rats also reported that GIP was released after infusion of lipid emulsion in the duodenal feeding tube (17). However, postprandial insulin levels were increased (6) or decreased (7) in humans following fat ingestion. Some studies have reported that acute postprandial effects differed among subjects that were healthy, obese, or had type 2 diabetes (18,19).…”

Section: Discussionmentioning

confidence: 83%

“…Fat evoked an incretin effect similar to than known for glucose 4 and stimulated GIP release at about 10 to 20 g ingestion (3,7). A previous study reported that saturated fatty acids increased insulin secretion (6). We used butter as a fat source because it is rich in saturated fatty acids and easy to eat.…”

Section: Discussionmentioning

confidence: 91%

“…In other words, fat induced GIP release and stored dietary fat via GIP and insulin release. Nevertheless, the studies are inconclusive, and insulin levels after the ingestion of dietary fat have been found to increase (6) or decrease (7). Furthermore, previous studies have reported that dietary fat intake induced the release of cholecystokinin (CCK) (8) and glucagon-like peptide -1 (GLP-1) (9).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of dose‐dependent effects of fat on blood glucose, serum insulin, and appetite sensation

Yamaguchi¹,

Yamanaka-Okumura²,

Esumi³

et al. 2018

J. Med. Invest.

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Humans have a high preference for fat, and its excessive intake leads to obesity. This study aimed to investigate the effects of dose-dependent fat intake on biological responses and postprandial appetite sensation in healthy adult subjects. Age and body mass index were 29 1 years and 21.1 0.4 kg/m 2 , respectively. We conducted a randomized, crossover trial and measured laboratory data and appetite sensation via the visual analog scale. Each participant was provided with four different test meals. They consisted of common, basic foods and contained 75 g liquid glucose and 4 slices of crackers to which 0 g butter (control), 10 g butter (B10), 20 g butter (B20), and 40 g butter (B40) were added, respectively. The results indicated that single ingestion of butter did not influence laboratory values of glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), total bile acids, or high-sensitivity CRP (hs -CRP). Regarding postprandial appetite sensation, appetite ratings for fullness were the highest after the B40 meal (p 0.05) ; however, satisfaction ratings were not significantly different after the ingestion of this meal. Ratings were significantly different after the B20 meal. In conclusion, healthy adult subjects experienced fullness and satisfaction after ingesting 20-40 g of butter.

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“…When the flux of amino acids into the β-cells is increased, they contribute to anaplerotic reactions that provide intermediates for the TCA cycle, as well as stimulate the entry of Ca 2+ into the cells [13]. The mechanism by which free fatty acids regulate GSIS is complicated, and beyond the scope of this review, however, interested readers may refer to several recent articles for more information [14][15][16][17][18][19][20]. In addition to macronutrients, various hormones, such as melatonin, estrogen, leptin, growth hormone, and glucagon-like peptide, also regulate insulin secretion [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Beta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion

et al. 2015

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Approximately 366 million people worldwide have been diagnosed with type-2 diabetes (T2D). Chronic insulin resistance, decreased functional β-cell mass, and elevated blood glucose are defining characteristics of T2D. Great advances have been made in understanding the pathogenesis of T2D with respect to the effects of dietary macronutrient composition and energy intake on β-cell physiology and glucose homeostasis. It has been further established that obesity is a leading pathogenic factor for developing insulin resistance. However, insulin resistance may not progress to T2D unless β-cells are unable to secret an adequate amount of insulin to compensate for decreased insulin sensitivity. Therefore, pancreatic β-cell dysfunction plays an important role in the development of overt diabetes. This paper reviews recent research findings on the effects of several micronutrients (zinc, vitamin D, iron, vitamin A), leucine, and the phytochemical, genistein on pancreatic β-cell physiology with emphasis on their effects on insulin secretion, specifically in the context of T2D.

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High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals

Cited by 22 publications

References 21 publications

Intestinal nutrient sensing and blood glucose control

Intestinal nutrient sensing and blood glucose control

Investigation of dose‐dependent effects of fat on blood glucose, serum insulin, and appetite sensation

Beta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion

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