Epilepsy is one of the most common neurological disorders that affect approximately 50 million people worldwide, with the prevalence of 1% in the population. Nearly 80% of people with epilepsy are found in developing countries, where the disease remains a major public health problem. It is not only because of its health implications but also for its social, cultural, psychological and economic effects. The person with epilepsy goes through many difficulties such as unpredictability of the seizures, adjustmental demands on personal and work life, family coping, problems in marital relationship, issues surrounding children, economic burden, and stigma about the disease apart from the access to treatment. Managing a chronic illness such as epilepsy involves more than managing medical problems. Social workers, as change agents, can fulfil their roles as educators, counsellors, and patient-advocates by helping patients and families to gain insight into the implications of chronic illness. The present cross sectional study was conducted among the Master of Social Work (MSW) students specialising in Medical and Psychiatric Social Work, with an attempt to look at the Knowledge and Attitude about Epilepsy. Thirty one students of Master of Social Work course with Medical and Psychiatric Social Work (males = 9; females = 22; age = 23.61, range 22-28 years) from different colleges in South India filled the questionnaire developed to assess the knowledge and attitudes about Epilepsy. All the respondents had heard about Epilepsy. The study revealed that while there is good awareness about Epilepsy among the students, majority of them felt that persons with Epilepsy should have restrictions in movement (84%) and that they have limitations in employment (58%). The implications of the study from knowledge development, research and practice are discussed.