High TG to HDL ratio plays a significant role on atherosclerosis extension in prediabetes and newly diagnosed type 2 diabetes subjects

Abstract

Aims We investigated the role of TG to HDL ratio (TG/HDL) on atherosclerosis extension, defined as presence of coronary artery calcium (CAC), carotid and femoral plaque, in prediabetes or newly diagnosed type 2 diabetes (T2D). Methods We performed a retrospective, cross‐sectional, single centre study involving 440 prediabetes or newly diagnosed controlled T2D subjects. Participants underwent CAC analysis by computed tomography and carotid and femoral plaque evaluation by ultrasonography and were stratified in high TG/HDL (H‐TG/HDL) or low TG/HDL (L‐TG/HDL) group according to TG/HDL median value. We estimated atherosclerosis extension according to the number of involved vascular districts. Results CAC was higher in the H‐TG/HDL group than L‐TG/HDL group (29.15 [0.0‐95.68] vs 0.0 [0.0‐53.97] AU, P < .01) and CAC > 0 was more prevalent in the H‐TG/HDL group than L‐TG/HDL group (64.5% vs 45%, P < .001). Femoral atherosclerosis was higher in the H‐TG/HDL group than L‐TG/HDL group (57.3% vs 43.6%, P < .01). H‐TG/HDL group exhibited a lower prevalence of subjects with 0‐TWP compared to L‐TG/HDL group (21.8% vs 38.6%, P < .01) and higher percentages of subjects with 2‐TWP or 3‐TWP than L‐TG/HDL group (for 2‐TWP 29.5% vs 21.5%, P < .05; for 3‐TWP 32.7% vs 20.9%, P < .01). Multiple logistic regression analysis showed that a H‐TG/HDL was inversely associated to 0‐TWP (P < .05) and positively associated with 2‐TWP (P < .05) and 3‐TWP (P < .01). Conclusions Our data suggest that TG/HDL is a marker of increased atherosclerotic extension in prediabetes and newly diagnosed T2D and may be useful to identify subjects with a higher cardiovascular risk profile.

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging

“…Therefore, we evaluated the possible impact that an altered lipid profile or lipid lowering and antihypertensive therapies could have on mitokine levels. We first subdivided T2D patients on the basis of the triglycerides/HDL (TG/HDL) ratio, known to be associated to insulin resistance and cardiovascular disease in T2D [ 49 , 50 ]. We found that patients with high TG/HDL ratio have higher level of GDF15 and FGF21 (Supplementary Table 1 ).…”

Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data

“…In previous studies, TG/HDL was often used to evaluate insulin resistance [34][35][36][37][38]. Recent studies have found a correlation between TG/HDL and the incidence of diabetes [39][40][41][42]. However, these studies did not include patients with prediabetes.…”

Effect of PCSK9 inhibitors on pulse wave velocity and monocyte-to-HDL-cholesterol ratio in familial hypercholesterolemia subjects: results from a single-lipid-unit real-life setting

“…Non-HDL cholesterol (non-HDL-C) was derived from baseline values. HbA1c was measured with high-performance liquid chromatography using a National Glycohemoglobin Standardization Program and standardized to the Diabetes Control and Complications Trial assay [32]. Chromatography was performed using a certified automated analyzer (HPLC; HLC-723G7 hemoglobin HPLC analyzer; Tosoh Corp.; normal range 4.25-5.9% [23-41 mmol/mol]).…”