High Sensitive Voltammetric Determination of Betamethasone on an Amalgam Film Electrode

Abstract

A voltammetric method for fast and high sensitive determination of betamethasone (BM) using an amalgam film silver based electrode (Hg(Ag)FE) was developed. Cyclic voltammetry study revealed that the BM reduction process is diffusion controlled with the participation of two electrons and two protons. In the optimum conditions, calibration curve was linear for BM in the concentration range from 5 • 10 −9 mol L −1 (1.96 • 10 −6 g L −1 ) to 0.8 • 10 −6 mol L −1 (3.14 • 10 −4 g L −1 ), with a detection limit of 1.6 • 10 −9 mol L −1 for preconcentration time of 45 s. Repeatability of method was determined as RSD % for betamethasone concentration of 0.1 • 10 −7 mol L −1 as 2.1% (n = 5). The proposed method was successfully applied and validated by studying the recovery of betamethasone in commercially available drugs.

Synthesis of Molecularly Imprinted Polymers (Mips) Used for Estimation of Betamethasone Disodium Phosphate (Bmsp) Using Different Functional Monomers

“…1, its is Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride, Natural and synthetic glucocorticoids are known to be highly effective drugs for the treatment of inflammatory diseases. They are widely administrated to relieve joint pain,symptoms of inflammatory skin problems and inflammation due to arthritis, asthma and rhinitis in clinical , It is active in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant, inflammatory bowel disease, reactive airways disease, and respiratory distress syndrome in preterm infants and pruritus in corticosteroidresponsive dermatoses, ulcerative colitis, lupus erythematosus, acute leukemia (14,18), BMSP was estimated in several ways, including the use of UPLC / MS / MS (6,11) , and was estimated using a voltammetric method (19), and the use of prepared and modified silica compounds (13), Methods were also developed using (RP-HPLC) (12,13), this study was formulation and evaluation of betamethasone sodium phosphate (BMSP) loaded chitosan nanoparticle(CNPs) using cross-linked chitosan malic acid derivative for better therapeutic effect. The prepared BMSP loaded CNPs (16) , A chiral biosensing platform was developed using (BMSP) as chiral recognition element through multilayered electrochemical deposition of BMSP, overoxidized polypyrrole, and nanosheets of graphene (OPPy-BMSP /GR), for enantio-recognition of mandelic acid (MA) enantiomers (9), Were Estimated (BMSP) using Novel magnetic molecularly imprinted polymer nanoparticles (MMIPs) using methacrylic acid as a functional monomer, MAEMA as a cross-linker, and betamethasone as a template The Fe3O4 nanoparticles were encapsulated with a SiO2 shell and functionalized with ACH@CH2 and MMIPs(7), were as Estimated (BMSP) using Novel magnetic molecularly imprinted polymer nanoparticles (MMIPs) using BY precipitation polymerization were prepared MMIPs were prepared by using methacrylic acid as a functional monomer, N,N-pphenylene bismethacryl amide as a crosslinking agent and betamethasone as template (8) of standard Betamethasone Sodium Phosphate in the methanol and completed to(100 mL) in the volumetric flask .The other solutions were prepared in100 mL at the ranged from (10-100 µg.ml -1 ) in the same procedure.…”

Intelligent Miniplatform for On-Site Monitoring of Water Samples and Pharmaceutical Production of Ointments Based on Betamethasone and Gentamicin as Active Pharmaceutical Ingredients

“…A literature study revealed that this is the first sensing platform developed for the simultaneous determination of betamethasone and gentamicin, while there are some electrochemical sensors designed for the individual determination of each drug molecule. [31][32][33][34][35][36][37][38] The originality of this work consists of the simultaneous determination of these two substances using an electrochemical approach, as well as its use on two types of samples: pharmaceutical and environmental.…”

Selective and Highly Sensitive Voltammetric Determination of Citalopram with Glassy Carbon Electrode

“…The application of electrochemical techniques for drug analysis recently gained in importance due to their simplicity, short response time, high selectivity, even for samples with complex matrices, and low cost of the apparatus. [32][33][34] Few works based on electrochemical techniques have been reported in the literature for determination of citalopram in tablets, biological fluids and water samples. The citalopram behavior was investigated using ion selective electrodes based on citalopram-tetraphenyl borate or citalopramphosphotungstate ion pair complexes.…”