High sensitivity and high <i>Q</i>-factor nanoslotted parallel quadrabeam photonic crystal cavity for real-time and label-free sensing

Yang, Daquan; Kita, Shota; Liang, Feng; Wang, Cheng; Tian, Huiping; Ji, Yuefeng; Lončar, Marko; Quan, Qimin

doi:10.1063/1.4867254

Cited by 96 publications

(50 citation statements)

References 37 publications

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“…This suggests successful attachment of Avidin with the functionalized ligand silane-PEG-Biotin on the tapered area. The sensor recorded detection limit of 0.2 M with RI and concentration sensitivity of 2526.8 nm/RIU and 20.368 nm=M respectively, which is comparable or even better than recent reports on protein sensors [8], [25]- [28]. We postulate the occurrence was as such due to the promotion of specific binding on the tapered region that resulted in a more concentrated attachment of targeted molecules on the tapered surface when compared with the floating molecules in bulk solution.…”

Section: Sensitivity Of Tapered Fiber With Different Concentrations Osupporting

confidence: 72%

Sensitive and Specific Protein Sensing Using Single-Mode Tapered Fiber Immobilized With Biorecognition Molecules

et al. 2015

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We examine and demonstrate a biosensor using single-mode tapered fiber that has been immobilized with biorecognition molecules to sense targeted proteins. Interaction of evanescent waves with the external medium surrounding the tapered region produces an interferometric-patterned spectrum, which shifts correspondingly to any changes of refractive index (RI) in the external medium. The proposed setup managed to obtain an RI sensitivity and concentration sensitivity of 2526.8 nm/RIU and 20.368 nm=M, respectively, which, to our knowledge, is highly sensitive when compared with previous studies. The dynamic performance, good specificity, and high sensitivity of the proposed method highlight an immensely beneficial choice for immunological diagnostics.

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Section: Sensitivity Of Tapered Fiber With Different Concentrations Osupporting

confidence: 72%

Sensitive and Specific Protein Sensing Using Single-Mode Tapered Fiber Immobilized With Biorecognition Molecules

et al. 2015

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“…4(a). Here we use pressure-bonding technique inspired by Quan et al [17]. For biosensing, PDMS is accepted universally as a bio-compatible microfluidic channel material.…”

Section: Fabrication and Integrationmentioning

confidence: 99%

Ultralow-loss waveguide crossings for the integration of microfluidics and optical waveguide sensors

et al. 2015

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Integrating photonic waveguide sensors with microfluidics is promising in achieving high-sensitivity and cost-effective biological and chemical sensing applications. One challenge in the integration is that an air gap would exist between the microfluidic channel and the photonic waveguide when the micro-channel and the waveguide intersect. The air gap creates a path for the fluid to leak out of the micro-channel. Potential solutions, such as oxide deposition followed by surface planarization, would introduce additional fabrication steps and thus are ineffective in cost. Here we propose a reliable and efficient approach for achieving closed microfluidic channels on a waveguide sensing chip. The core of the employed technique is to add waveguide crossings, i.e., perpendicularly intersecting waveguides, to block the etched trenches and prevent the fluid from leaking through the air gap. The waveguide crossings offer a smooth interface for microfluidic channel bonding while bring negligible additional propagation loss (0.024 dB/crossing based on simulation). They are also efficient in fabrication, which are patterned and fabricated in the same step with waveguides. We experimentally integrated microfluidic channels with photonic crystal (PC) microcavity sensor chips on silicon-on-insulator substrate and demonstrated leak-free sensing measurement with waveguide crossings. The microfluidic channel was made from polydimethylsiloxane (PDMS) and pressure bonded to the silicon chip. The tested flow rates can be varied from 0.2 µL/min to 200 µL/min. Strong resonances from the PC cavity were observed from the transmission spectra. The spectra also show that the waveguide crossings did not induce any significant additional loss or alter the resonances.

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“…11 On the other hand, photonic crystal (PhC) cavities have emerged as a powerful alternative for applications that require strong light confinements. [12][13][14][15][16][17][18][19][20][21] Theoretically, PhC cavities could achieve a similar level of Q factors as WGM resonators, but with much smaller V m . 22 In the past few years, promising results on single-nanoparticle sensing, trapping, and manipulation based on PhC cavities have been reported.…”

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confidence: 97%

“…The proposed cavities possess experimental Q factors $12 000, which represent the highest measured value in similar slotted configurations. 21,27 Moreover, our cavities provide strong light confinement in the slotted regions with V m as low as 0.06 (k/n water ) 3 , boosting their performance in sensing applications. The measured refractive index sensitivity is 439 6 3 nm/RIU, more than 5 times better than a typical non-slot nanobeam cavity.…”

mentioning

confidence: 98%

Single-nanoparticle detection with slot-mode photonic crystal cavities

Wang

Quan

Kita

et al. 2015

Applied Physics Letters

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Optical cavities that are capable for detecting single nanoparticles could lead to great progress in early stage disease diagnostics and the study of biological interactions on the single-molecule level. In particular, photonic crystal (PhC) cavities are excellent platforms for label-free single-nanoparticle detection, owing to their high quality (Q) factors and wavelength-scale modal volumes. Here, we demonstrate the design and fabrication of a high-Q (>104) slot-mode PhC nanobeam cavity, which is able to strongly confine light in the slotted regions. The enhanced light-matter interaction results in an order of magnitude improvement in both refractive index sensitivity (439 nm/RIU) and single-nanoparticle sensitivity compared with conventional dielectric-mode PhC cavities. Detection of single polystyrene nanoparticles with radii of 20 nm and 30 nm is demonstrated in aqueous environments (D2O), without additional laser and temperature stabilization techniques.

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High sensitivity and high Q-factor nanoslotted parallel quadrabeam photonic crystal cavity for real-time and label-free sensing

Cited by 96 publications

References 37 publications

Sensitive and Specific Protein Sensing Using Single-Mode Tapered Fiber Immobilized With Biorecognition Molecules

Sensitive and Specific Protein Sensing Using Single-Mode Tapered Fiber Immobilized With Biorecognition Molecules

Ultralow-loss waveguide crossings for the integration of microfluidics and optical waveguide sensors

Single-nanoparticle detection with slot-mode photonic crystal cavities

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