High‐sensitivity C‐reactive protein: A predicative marker in severe asthma

Qian, Fen-Hong; Zhang, Qian; Zhou, Lei; Liu, Hua; Huang, Mao; Zhang, Xilong; Yin, Kai

doi:10.1111/j.1440-1843.2008.01314.x

Cited by 59 publications

(44 citation statements)

References 31 publications

(39 reference statements)

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“…Also, serum hs-CRP showed significant positive correlation with asthma severity and significant negative correlation with ACT and FEV 1 % of predicted in all studied asthmatic patients. These results are in accordance with Takemura et al [13], Kilic et al [14] and Qian et al [15] who explained that inflammatory process differs with staging of asthma after the exclusion of the role of infection. The severity of the disease significantly relies on the volume of the bronchial inflammation and the amount of inflammatory mediators released in circulation and hence the acute phase reactant will be synthesized by the liver, CRP is one of the most important acute phase reactants.…”

Section: Discussionsupporting

confidence: 92%

Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients

Sileem

Embarak

Meleha

2014

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: High sensitive C-reactive protein (hs-CRP) and eosinophilic cationic protein (ECP) have been shown to be associated with asthma in recent studies. However, the relationship between hs-CRP and the control of asthma has not been clearly identified yet.Patients and methods: Thirty patients with newly-diagnosed bronchial asthma and 20 healthy individuals were enrolled in this study. In addition to medical history and physical examination, asthma was assessed according to the Global Initiative for Asthma (GINA) guidelines. Respiratory function tests (RFT), serum hs-CRP and ECP levels, serum total IgE levels, circulating eosinophil count (CE) and asthma control test (ACT) were performed for all subjects.Results: Serum ECP, serum hs-CRP, serum total IgE and CE were significantly higher (p < 0.01, 0.01, 0.05 and 0.05, respectively), while forced expiratory volume in 1 s (FEV 1 %) and ACT were significantly lower (p < 0.05) in asthmatic patients compared to the control group. In all patients with bronchial asthma, serum levels of hs-CRP and ECP showed significant positive correlations with asthma severity (hs-CRP, r s = 0.59, p < 0.01; ECP, r s = 0.63, p < 0.01, respectively) but, significant negative correlations with ACT (hs-CRP, r s = À0.53, p < 0.05; ECP, r s = À0.62, p < 0.01, respectively) and FEV 1 % (hs-CRP, r s = À0.46, p < 0.05; ECP, r s = À0.57, p < 0.01, respectively). Serum ECP and hs-CRP levels showed significant fall (p < 0.01and p < 0.05, respectively), while, FEV 1 % and ACT showed significant increase (p < 0.05) in asthmatic patients who were followed up after 2 months of therapy.

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Section: Discussionsupporting

confidence: 92%

Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients

Sileem

Embarak

Meleha

2014

Egyptian Journal of Chest Diseases and Tuberculosis

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“…Mild persistent asthma was also the commonest form of asthma severity in children at 1 year follow up in Beninas reported by Oviawe et al 18 . This pattern was not in conformity with the findings of Qianet al 19 where severe persistent asthmatic subjects constituted the largest group with 37.0%, followed by mild intermittent with 29.9%, moderate persistent were 22.4% and mild persistent 10.7%. Reason for this difference may be due to a larger sample size used by Qianet al 19 where 281 asthmatic subjects were studied.…”

Section: Discussioncontrasting

confidence: 86%

“…This pattern was not in conformity with the findings of Qianet al 19 where severe persistent asthmatic subjects constituted the largest group with 37.0%, followed by mild intermittent with 29.9%, moderate persistent were 22.4% and mild persistent 10.7%. Reason for this difference may be due to a larger sample size used by Qianet al 19 where 281 asthmatic subjects were studied. Another explanation for the difference may be probably because developed countries have high level of industrialization with attendant dusty air and air pollutants which may contribute to severe persistent asthma seen in such countries.…”

Section: Discussioncontrasting

confidence: 86%

Socio-demographic and clinical characteristics of asthmatic children seen at Aminu Kano Teaching Hospital, Kano, Nigeria

BI¹,

Ibrahim²,

Johnson³

2014

Nig. J. Paed.

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Introduction: Asthma is a chronic inflammatory disorder associated with variable air flow obstruction and bronchial hyperresponsiveness. It is characterised clinically by recurrent episodes of cough, difficulty in breathing and wheezing which resolves spontaneously or with treatment. The socio-demographic and clinical characteristics of asthmatic children in north western Nigeria have not been reported. Methods: This was a descriptive study in children with asthma aged 4-15 years carried out over a 3 month period Aminu Kano Teaching Hospital (AKTH), Kano. The aim was to determine the socio-demographic and clinical parameters of asthmatic children. Asthmatic children whose parents or guardian consented to the study were recruited consecutively. Their bio-data, sociodemographic and physical examination were documented. Results: Seventy asthmatic children were recruited of which 50(71.4%) were males and 20(28.6%) were females, giving a male: female ratio of 2.5:1. Insecticide was the commonest asthma trigger (64.3%) and 26(37.1%) patients belonged to socio economic class III. Mild persistent asthma was the commonest form of asthma severity encountered. There was positive correlation between PEFR and height (r = 0.577, p< 0.0001). Conclusion: Most of the asthmatics children seen at AKTH, Kano were males with mild persistent asthma, had positive family history of atopy and belonged to the middle socio economic class.

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“…Moreover, in a small recently published prospective cross-sectional study in patients with mild asthma it was reported that sputum IL-6 levels correlated inversely with postbronchodilator FEV 1 6. IL-6 is responsible for the modulation of synthesis of acute phase proteins such as C-reactive protein, whose serum level is increased in severe asthma 7. IL-6 induces its inflammatory activity by interacting with its receptor and a signal transducing non-ligand (gp130), but also via the soluble IL-6 receptor (sIL-6R) 8.…”

mentioning

confidence: 99%

Sputum IL-6 concentrations in severe asthma and its relationship with FEV1

Morjaria

Babu²,

Vijayanand³

et al. 2010

Thorax

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High‐sensitivity C‐reactive protein: A predicative marker in severe asthma

Abstract: These findings suggest that hs-CRP might be a sensitive marker for severe asthma.

Cited by 59 publications

References 31 publications

Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients

Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients

Socio-demographic and clinical characteristics of asthmatic children seen at Aminu Kano Teaching Hospital, Kano, Nigeria

Sputum IL-6 concentrations in severe asthma and its relationship with FEV1

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