High-sensitivity C-reactive Protein and Tumor Necrosis Factor Alpha in Pseudoexfoliation Syndrome

Sorkhabi, Rana; Ghorbanihaghjo, Amir; Ahoor, Mohamadhosein; Mehriar, Nahaei; Rashtchizadeh, Nadereh

doi:10.5001/omj.2013.04

Cited by 31 publications

(17 citation statements)

References 27 publications

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“…12 Sorkhabi et al studied high-sensitivity C-reactive protein and tumor necrosis factor alpha in PEXS and mentioned that increased levels of these markers, as signs of inflammation and peripheral endothelial dysfunction, may be risk factors for systemic and ocular manifestations of PEXS. 13 In contrast, high-sensitivity C-reactive protein had not been found as a predictive marker of inflammation and peripheral endothelial dysfunction in PEXS and PEXG. 14 The inflammation is an important component of other ocular diseases such as age-related macular degeneration (AMD) and vascular diseases of retina.…”

Section: Discussionmentioning

confidence: 99%

Elevated neutrophil-to-lymphocyte ratio in pseudoexfoliation syndrome

Kurtul

Özer

Kabataş

2016

Eye

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Section: Discussionmentioning

confidence: 99%

Elevated neutrophil-to-lymphocyte ratio in pseudoexfoliation syndrome

Kurtul

Özer

Kabataş

2016

Eye

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“…Sorkhabi et al reported that tumour necrosis factor‐α and C‐reactive protein levels in a group with pseudoexfoliation were significantly higher than in controls. In this study, inflammation was also thought to be involved in pseudoexfoliation …”

Section: Discussionmentioning

confidence: 85%

“…In this study, inflammation was also thought to be involved in pseudoexfoliation. 36 Although there have been studies about oxidative damage in lens epithelial cells of patients with pseudoexfoliation, there apparently have been no reports of the level of PEDF in lens epithelial cells in patients with pseudoexfoliation. The present study found that PEDF levels were significantly lower in anterior capsule material of cataract patients with pseudoexfoliation than in those without pseudoexfoliation.…”

Section: Discussionmentioning

confidence: 99%

Pigment epithelial‐derived factor in the lens anterior capsule of patients with senile cataract with pseudoexfoliation

Utlu

Salman

Öztürk

2020

Clinical and Experimental Optometry

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Background This study sought to evaluate pigment epithelial‐derived factor (PEDF) levels in lens anterior capsule material taken during cataract surgery from patients with senile cataract with pseudoexfoliation. Methods The study included 90 eyes of 86 patients who were diagnosed with, and underwent surgery for, cataracts. Sixty of the eyes included in the study had senile cataract. Thirty eyes of 30 young patients with other forms of cataract were included as a control group. Pseudoexfoliation was present in 21 patients with senile cataract. PEDF levels in the lens anterior capsule material – extracted with capsulorhexis in the classical phacoemulsification procedure – were measured by the enzyme‐linked immunosorbent assay method and compared between the groups. Results The PEDF level in the lens anterior capsule in the senile cataract patient group was 149.36 ± 17.46 pg/ml. A statistically significant lower level of PEDF was found in the lens anterior capsule of patients with senile cataract compared with the other groups. In the patient group with pseudoexfoliation, the PEDF level in the lens anterior capsule was found to be statistically significantly lower than the patient group without pseudoexfoliation. Conclusion PEDF levels decrease with senile cataract and pseudoexfoliation. These findings may clarify the pathogenesis of these conditions and point toward alternative treatment modalities.

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“…Similarly, Turkyilmaz et al 24 have shown a relationship between PES and elevated serum levels of YKL-40 (chitinase-3-like protein 1), which has a role in endothelial dysfunction and inflammation. To date, elevated serum levels of several other molecules that have definitive roles in inflammatory processes (eg, cardiovascular and cerebrovascular disease, endothelial dysfunction), including high-sensitivity C-reactive protein, 25 tumor necrosis factora, 25 antiphospholipid antibody, 26 a 1-antitrypsin, 27 homocysteine, 28 and hydroxyproline 29 have been studied in the serum of patients with PES. In the present study, serum omentin levels were found to be lower in patients with PES compared with healthy controls.…”

Section: Discussionmentioning

confidence: 99%