High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS)

Abstract

C-reactive protein (CRP) is a risk marker for type 2 diabetes mellitus and cardiovascular diseases. In polycystic ovary syndrome (PCOS), limited data are available on high-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of PCOS especially in Indian women. The objective was to determine serum hs-CRP concentration in adolescent women with and without PCOS and to assess possible correlations of serum hs-CRP levels with components of PCOS in Indian women. One hundred and sixty women with PCOS and sixty non-PCOS women having normal menstrual cycles were included. Clinical assessment included anthropometry, Ferriman-Gallwey (FG) score and blood pressure (BP) measurement. Laboratory evaluation included estimation of T4, TSH, LH, FSH, total testosterone, prolactin, cortisol, 17OHP, hs-CRP, lipid profile, and insulin, and glucose after 2-h oral glucose tolerance test. Homeostasis Model Assessment Insulin resistance index (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) and glucose intolerance was calculated. FG score, LH, FSH, total Testosterone, HOMA-IR and QUICKI were significantly different among women with or without PCOS (p < 0.01). Although hs-CRP levels showed a higher trend in women having PCOS, there was no significant difference between the groups (p > 0.05). A significant and positive correlation was found between hs-CRP and body mass index (BMI) (r = 0.308, p < 0.01) among PCOS group. The results in Indian adolescent women suggest that hs-CRP levels may not per se be associated with PCOS, rather can be related to fat mass in this subset of subjects.

Adolescents with Classical Polycystic Ovary Syndrome Have Alterations in the Surrogate Markers of Cardiovascular Disease but Not in the Endothelial Function. The Possible Benefits of Metformin

“…The present study shows that adolescents with classical PCOS and insulin resistance and/or hyperinsulinemia are characterized by an inflammatory state as suggested by the presence of higher values of CRP, compared to the controls. No change in CRP was observed by Ganie et al 25 in a larger sample of PCOS adolescents. Because of the correlation observed between CRP and BMI, the higher BMI of our adolescents may explain the different results confirming that the heterogeneity of this endocrine disorder may lead to different findings.…”

Prevalence of polycystic ovary syndrome (PCOS) among reproductive age women from Kashmir valley: A cross‐sectional study

“…In comparison to western communities and other Asian communities, Indian women have been reported to have a higher prevalence of PCOS. A prevalence rate of PCOS in Indian women is in the range of 3.7%–36% . Nair et al .…”

Oral glucose tolerance test significantly impacts the prevalence of abnormal glucose tolerance among Indian women with polycystic ovary syndrome: lessons from a large database of two tertiary care centers on the Indian subcontinent

“…The prevalence of this disorder is on the rise globally and seems to run parallel to the epidemic of type 2 diabetes mellitus (DM) in India (3,4). Though Stein and Leventhal (5) originally described it as a reproductive disorder, and an association with several other metabolic derangements including obesity, insulin resistance (IR), abnormal glucose tolerance (AGT), dyslipidemia, hypertension, metabolic syndrome, and elevated cardiovascular risk has also been described (6)(7)(8)(9). The etiology of the disorder being largely unclear; it seems to follow a polygenic pattern like type 2 DM.…”