High-sensitivity C-reactive protein levels and pregnancy outcomes in women with unexplained infertility after ovarian stimulation with intrauterine insemination in a multicenter trial

Gavrizi, Sarah Z.; Arya, Sushila; Peck, Jennifer D.; Knudtson, Jennifer F.; Diamond, Michael P.; Wild, Robert A.; Hansen, Karl R.

doi:10.1016/j.xfre.2022.01.001

Cited by 2 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The higher CRP levels of our study group could therefore not be explained by these factors associated with infertility. The results of a recently published study on 781 couples with unexplained infertility suggest that a chronic inflammatory status could raise the chance of pregnancy loss but may not affect the clinical pregnancy rate in females with unexplained infertility that are under treatment for ovulation induction followed by intrauterine insemination because of unexplained infertility ( 32 ). Although moderate inflammation is present in 20-40% of females of reproductive age, assessment of serum CRP levels is not included in routine diagnostic for infertility evaluation so far ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Iron status in women with infertility and controls: a case-control study

Holzer,

Ott,

Beitl

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundIron deficiency is a common problem in subfertile women. The influence of iron status on unexplained infertility is unknown.MethodsIn a case-control study, 36 women with unexplained infertility and 36 healthy non-infertile controls were included. Parameters of iron status including serum ferritin and a serum ferritin <30 µg/dL served as main outcome parameters.ResultsWomen with unexplained infertility demonstrated a lower transferrin saturation (median 17.3%, IQR 12.7-25.2 versus 23.9%, IQR 15.4-31.6; p= 0.034) and a lower mean corpuscular hemoglobin concentration (median 33.6 g/dL, IQR 33.0-34.1 versus 34.1 g/dL, IQR 33.2-34.7; p= 0.012). Despite the fact that there was no statistically significant difference in median ferritin levels (p= 0.570), women with unexplained infertility had ferritin levels <30µg/L more often (33.3%) than controls (11.1%; p= 0.023). In a multivariate model, unexplained infertility and abnormal thyroid antibodies were associated with ferritin <30µg/L (OR 4.906, 95%CI: 1.181-20.388; p= 0.029 and OR 13.099; 2.382-72.044; p= 0.029, respectively).ConclusionFerritin levels <30µg/L were associated with unexplained infertility and might be screened in the future. Further studies with a focus on iron deficiency and iron treatment on women with unexplained infertility are warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Iron status in women with infertility and controls: a case-control study

Holzer,

Ott,

Beitl

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…And LDA treatment may be associated with higher ratio of having a live-born male among women with 1 to 2 prior pregnancy losses, even if Frontiers in Public Health 07 frontiersin.org women were at higher levels of inflammation (55). In addition, basal hs-CRP levels may have the potential to serve as a clinical marker to identify patients at increased risk of pregnancy loss (56). Therefore, additional investigations of targeted interventions to reduce inflammation are needed to assess the effects on pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

Previous pregnancy loss and gestational cardiovascular health: A prospective cohort of nulliparous women

Yin

Wang

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

ObjectivesTo estimate the association of previous pregnancy loss with subsequent cardiovascular health during gestation and to examine the role of high-sensitivity C reactive protein (hs-CRP) in the association.MethodsA total of 2,778 nulliparous pregnant women were recruited between March 2015 and November 2020 in Hefei city, China. Their cardiovascular health (CVH) including prepregnancy body mass index (BMI), blood pressure, total cholesterol, fasting plasma glucose, and smoke status were recorded at 24–28 weeks’ gestation, as well as their reproductive history. Multivariate linear and logistic regression were performed to examine the association of pregnancy loss with cardiovascular health. And the role of hs-CRP between pregnancy loss and CVH was assessed by the mediation analysis.ResultsCompared with women who have no pregnancy loss, women with a history of spontaneous or induced abortions had higher BMI (β, 0.72, 95% CI, 0.50 to 0.94) and fasting plasma glucose (β, 0.04, 95% CI, 0.01 to 0.07), and had lower total CVH scores after adjusting for confounders (β, −0.09, 95% CI, −0.18 to −0.01). CVH scores were most significantly decreased among women with 3 or more induced abortions (β, −0.26, 95% CI, −0.49, −0.02). The contribution of pregnancy loss to poorer gestational CVH mediated by increased hs-CRP levels was 23.17%.ConclusionPrevious pregnancy loss was associated with poorer cardiovascular health during gestation, which may be mediated by their gestational inflammatory status. Exposure to miscarriage alone was not a significant predictor of poorer CVH.

show abstract

High-sensitivity C-reactive protein levels and pregnancy outcomes in women with unexplained infertility after ovarian stimulation with intrauterine insemination in a multicenter trial

Cited by 2 publications

References 29 publications

Iron status in women with infertility and controls: a case-control study

Iron status in women with infertility and controls: a case-control study

Previous pregnancy loss and gestational cardiovascular health: A prospective cohort of nulliparous women

Contact Info

Product

Resources

About