High-sensitivity cardiac troponin T is superior to troponin I in the prediction of mortality in patients without acute coronary syndrome

Árnadóttir, Ásthildur; Vestergaard, Kirstine Roll; Pallisgaard, Jannik Langtved; Sölétormos, György; Steffensen, Rolf; Goetze, Jens P.; Iversen, Kasper

doi:10.1016/j.ijcard.2018.01.131

Cited by 29 publications

(14 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients without ACS, the prognostic performance of hs‐cTnT for all‐cause mortality seems superior to that of hs‐cTnI, while the diagnostic value of cTnT and cTnI has been considered comparable in patients with ACS. In accordance with these findings, in AIS patients, the elevation of cTnT may be more sensitive to predict unfavorable outcomes as opposed to cTnI .…”

Section: Discussionmentioning

confidence: 99%

Elevation of high‐sensitivity cardiac troponin T at admission is associated with increased 3‐month mortality in acute ischemic stroke patients treated with thrombolysis

Sui

Liu

Luo

et al. 2019

Clinical Cardiology

View full text Add to dashboard Cite

Background Elevated levels of cardiac troponin T (cTnT) have been associated with unfavorable outcomes in cardiac patients. However, no studies, to date, have discussed the prognostic value of high‐sensitivity cTnT (hs‐cTnT) in thrombolyzed patients with acute ischemic stroke (AIS). Hypothesis We hypothesized that elevated levels of hs‐cTnT would be associated with poorer clinical outcomes in AIS patients treated with intravenous tissue‐type plasminogen activator (IV tPA). Methods From January 2017 to February 2018, a total of 241 AIS patients treated with IV tPA within 4.5 hours of onset were recruited. On admission, patients were stratified into either normal or elevated hs‐cTnT groups according to a cutoff value of 14 ng/L. Multivariable logistic regression analyses were conducted to identify determinants of hs‐cTnT elevation and to detect whether elevated hs‐cTnT was associated with disability and/or mortality. Results In multivariable regression analysis, older age (P < .001) and stroke etiology (P = .024) were significantly associated with elevated hs‐cTnT levels. After adjusting for demographic and clinical characteristics, hs‐cTnT elevation was still significantly associated with 14‐day major disability (modified Rankin Scale (mRS) 3‐5, model 1, P = .019, odds ratio [OR] 2.677; model 2, P = .015, OR 2.834), 14‐day composite unfavorable outcome (mRS 3‐6, model 1, P = .005, OR 3.525; model 2, P = .003, OR 3.976), 30‐day mortality (P = .049, OR 4.545) and 90‐day mortality (P = .049, OR 3.835). Conclusions Elevation of hs‐cTnT at admission is associated with an increased risk of 90‐day mortality in AIS patients treated with IV tPA.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevation of high‐sensitivity cardiac troponin T at admission is associated with increased 3‐month mortality in acute ischemic stroke patients treated with thrombolysis

Sui

Liu

Luo

et al. 2019

Clinical Cardiology

View full text Add to dashboard Cite

show abstract

“…The test must be turned around rapidly and the physician notified of a positive research test result immediately. In addition, there is a difference between troponin T and troponin I in the prediction of mortality in patients presenting to the emergency department, with troponin T more predictive of death, raising the possibility that one assay may be superior as a peritransfusion measurement . Cardiac biomarkers with a high specificity are greatly needed to help differentiate TACO and TRALI, with the latter assignment having negative impacts on donor eligibility for future donations and hence the need to avoid misclassification of TACO as TRALI.…”

Section: Discussionmentioning

confidence: 99%

Cardiac stress biomarkers after red blood cell transfusion in patients at risk for transfusion‐associated circulatory overload: a prospective observational study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…9,10 Patients were eligible for inclusion in this study if they had participated in the previous study and had hs-cTnT concentration above the 99th percentile and normal plasma creatinine (n = 224). The rationale and methodology has been described previously.…”

Section: Study Populationmentioning

confidence: 99%

“…The rationale and methodology has been described previously. 9,10 Patients were eligible for inclusion in this study if they had participated in the previous study and had hs-cTnT concentration above the 99th percentile and normal plasma creatinine (n = 224). Exclusion criteria were history of previous cardiac disease (n = 92), terminal cancer (n = 12), not being able to provide written consent (n = 28) and 30 patients were deceased.…”

Section: Study Populationmentioning

confidence: 99%

Prediction of coronary heart disease or heart failure using high‐sensitivity cardiac troponin T: A pilot study

Árnadóttir

Vestergaard

Sölétormos

et al. 2018

Eur J Clin Investigation

Self Cite

View full text Add to dashboard Cite

show abstract

High-sensitivity cardiac troponin T is superior to troponin I in the prediction of mortality in patients without acute coronary syndrome

Cited by 29 publications

References 31 publications

Elevation of high‐sensitivity cardiac troponin T at admission is associated with increased 3‐month mortality in acute ischemic stroke patients treated with thrombolysis

Elevation of high‐sensitivity cardiac troponin T at admission is associated with increased 3‐month mortality in acute ischemic stroke patients treated with thrombolysis

Cardiac stress biomarkers after red blood cell transfusion in patients at risk for transfusion‐associated circulatory overload: a prospective observational study

Prediction of coronary heart disease or heart failure using high‐sensitivity cardiac troponin T: A pilot study

Contact Info

Product

Resources

About