High sensitivity label-free refractometer based biosensor applicable to glycated hemoglobin detection in human blood using all-circular photonic crystal ring resonators

Tavousi, Alireza; Rakhshani, Mohammad Reza; Mansouri-Birjandi, Mohammad Ali

doi:10.1016/j.optcom.2018.08.019

Cited by 95 publications

(26 citation statements)

References 49 publications

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“…Optical biosensors are considered as a primary sensing method in detection of blood samples, which measure the different refractive indices of blood sample with different concentrations of hemoglobin 18 . Lab-on-a-chip biosensor with integrated optical transducers responds more to electromagnetic interference than to electronic components, which solves the Maxwell’s equation and results in good sensitivity 19 . Graphene oxide and reduced graphene oxide can detect bacteria at the micro level; between the two, reduced graphene oxide is more effective as it produces less noises 20 .…”

Section: Introductionmentioning

confidence: 99%

Tunable infrared metamaterial-based biosensor for detection of hemoglobin and urine using phase change material

Patel

Parmar

Sorathiya

et al. 2021

Sci Rep

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This paper reports about the outcomes from an investigation carried out on tunable biosensor for detection using infrared in the range of 1.5 µm and 1.65 µm. The biosensor is made of phase change material formed by different alloy combinations, Ge2Sb2Te5 (GST). The nature of GST allows for the material to change phase with changes in temperature, giving the tunable sensing property for biosensing application. Sensor built with amorphous GST (aGST) and crystalline GST (cGST) in different design structures were tested on different concentrations of biomolecules: hemoglobin (10 g/l, 20 g/l, 30 g/l and 40 g/l); and urine (0–1.5 mg/dL, 2.5 mg/dL, 5 mg/dL and 10 mg/dL). The tunable response observed from the tests demonstrates the potential application of the materials in the design of switching and sensing systems.

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Section: Introductionmentioning

confidence: 99%

Tunable infrared metamaterial-based biosensor for detection of hemoglobin and urine using phase change material

Patel

Parmar

Sorathiya

et al. 2021

Sci Rep

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“…In recent years, there has been great progress in the construction of biosensors and similar methods for the HbA 1c assay [ 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ]. Various optical and electro-optical sensor methods have been developed in the past few years.…”

Section: Biosensors and Bioassays Measuring Hba 1cmentioning

confidence: 99%

Glycated Hemoglobin and Methods for Its Point of Care Testing

Pohanka

2021

Biosensors

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Glycated hemoglobin (HbA1c) is a product of the spontaneous reaction between hemoglobin and elevated glucose levels in the blood. It is included among the so-called advanced glycation end products, of which is the most important for the clinical diagnosis of diabetes mellitus, and it can serve as an alternative to glycemia measurement. Compared to the diagnosis of diabetes mellitus by glycemia, the HbA1c level is less influenced by a short-term problem with diabetes compensation. Mass spectroscopy and chromatographic techniques are among the standard methods of HbA1c level measurement. Compared to glycemia measurement, there is lack of simple methods for diabetes mellitus diagnosis by means of the HbA1c assay using a point-of-care test. This review article is focused on the surveying of facts about HbA1c and its importance in diabetes mellitus diagnosis, and surveying standard methods and new methods suitable for the HbA1c assay under point-of-care conditions. Various bioassays and biosensors are mentioned and their specifications are discussed.

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“…Recent activities are demonstrated in [142]. In many publications, the high sensitivity is argued as an advantage of such ring resonator systems [143]. In [10], optical biosensors based on integrated photonic devices with a special view on silicon-oninsulator ring resonators are reviewed with respect to sensing mechanism, sensor design, and biofunctionalization.…”

Section: Fibers and Waveguides Without Structurementioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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Direct optical detection has proven to be a highly interesting tool in biomolecular interaction analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis, clinical diagnostics, screening of large data volumes in immunology, cancer therapy, or personalized medicine. In this review, the fundamental optical principles and applications are reviewed. Devices are based on concepts such as refractometry, evanescent field, waveguides modes, reflectometry, resonance and/or interference. They are realized in ring resonators; prism couplers; surface plasmon resonance; resonant mirror; Bragg grating; grating couplers; photonic crystals, Mach-Zehnder, Young, Hartman interferometers; backscattering; ellipsometry; or reflectance interferometry. The physical theories of various optical principles have already been reviewed in detail elsewhere and are therefore only cited. This review provides an overall survey on the application of these methods in direct optical biosensing. The "historical" development of the main principles is given to understand the various, and sometimes only slightly modified variations published as "new" methods or the use of a new acronym and commercialization by different companies. Improvement of optics is only one way to increase the quality of biosensors. Additional essential aspects are the surface modification of transducers, immobilization strategies, selection of recognition elements, the influence of non-specific interaction, selectivity, and sensitivity. Furthermore, papers use for reporting minimal amounts of detectable analyte terms such as value of mass, moles, grams, or mol/L which are difficult to compare. Both these essential aspects (i.e., biochemistry and the presentation of LOD values) can be discussed only in brief (but references are provided) in order to prevent the paper from becoming too long. The review will concentrate on a comparison of the optical methods, their application, and the resulting bioanalytical quality.

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High sensitivity label-free refractometer based biosensor applicable to glycated hemoglobin detection in human blood using all-circular photonic crystal ring resonators

Cited by 95 publications

References 49 publications

Tunable infrared metamaterial-based biosensor for detection of hemoglobin and urine using phase change material

Tunable infrared metamaterial-based biosensor for detection of hemoglobin and urine using phase change material

Glycated Hemoglobin and Methods for Its Point of Care Testing

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

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